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Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.

التفاصيل البيبلوغرافية
العنوان: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.
المؤلفون: Fernández-Rhodes L; Department of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Buchanan VL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Justice AE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA 17822, USA., Highland HM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Zhu W; Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Chen HH; Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Adhikari K; School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, MK7 6AA Milton Keynes, UK., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA., Below JE; Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Bradfield J; Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil., Glover L; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kim D; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lilly AG; Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Shrestha P; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Thomas AG; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhang X; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Chen M; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Chiang CWK; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90007, USA., Pulit S; Vertex Pharmaceuticals, W2 6BD Oxford, UK., Horimoto A; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo 05508-220, Brazil., Guindo-Martínez M; The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark., Preuss M; The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schumann C; Hasso Plattner Institute, University of Potsdam, Digital Health Center, 14482 Potsdam, Germany., Smit RAJ; The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Torres-Mejía G; Department of Research in Cardiovascular Diseases, Diabetes Mellitus, and Cancer, Population Health Research Center, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico., Acuña-Alonzo V; National Institute of Anthropology and History, Mexico City 06600, Mexico., Bedoya G; Molecular Genetics Investigation Group, University of Antioquia, Medellín 1226, Colombia., Bortolini MC; Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, Brazil., Canizales-Quinteros S; Population Genomics Applied to Health Unit, The National Institute of Genomic Medicine and the Faculty of Chemistry at the National Autonomous University of Mexico, Mexico City 04510, Mexico., Gallo C; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru., González-José R; Patagonian Institute of the Social and Human Sciences, Patagonian National Center, Puerto Madryn U9120, Argentina., Poletti G; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru., Rothhammer F; Institute of High Studies, University of Tarapacá, Arica 1000000, Chile., Hakonarson H; Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Igo R; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., Adler SG; Division of Nephrology and Hypertension, Harbor-University of California Los Angeles Medical Center, Torrance, CA 90502, USA., Iyengar SK; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., Nicholas SB; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Papnicolaou G; National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Kho M; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Langefeld CD; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA., Wagenknecht L; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA., Mckean-Cowdin R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA., Gao XR; Department of Ophthalmology and Visual Sciences, Department of Biomedical Informatics, Division of Human Genetics, The Ohio State University, Columbus, OH 43210, USA., Nousome D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA., Conti DV; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Feng Y; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA., Allison MA; Department of Family Medicine, University of California, San Diego, CA 92161, USA., Arzumanyan Z; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Buchanan TA; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Genter PM; Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Hai Y; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Hsueh W; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Ipp E; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.; Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Kandeel FR; Department of Translational Research & Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA., Lam K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Nadler JL; Department of Pharmacology at New York Medical College School of Medicine, Valhalla, NY 10595, USA., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA 92697, USA., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Xiang AH; Research and Evaluation Branch, Kaiser Permanente of Southern California, Pasadena, CA 91101, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Audirac-Chalifour A; Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico., de Jesus Peralta Romero J; Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico., Hartwig F; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas 96010-610, Brazil., Horta B; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas 96010-610, Brazil., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX 78520 and 78539, USA., Lehman DE; Department of Medicine, School of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Puppala S; Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA., Fejerman L; Department of Public Health Sciences, School of Medicine, and the Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA., John EM; Departments of Epidemiology & Population Health and Medicine-Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Aguilar-Salinas C; Division of Nutrition, Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City 14080, Mexico., Burtt NP; Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Florez JC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., García-Ortíz H; Laboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City 14610, Mexico., González-Villalpando C; Center for Diabetes Studies, Research Unit for Diabetes and Cardiovascular Risk, Center for Population Health Studies, National Institute of Public Health, Mexico City 14080, Mexico., Mercader J; Programs in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Orozco L; Laboratory of Immunogenomics and Metabolic Diseases, National Institute of Genomic Medicine, Mexico City 14610, Mexico., Tusié-Luna T; Molecular Biology and Medical Genomics Unity, Institute of Biomedical Research, The National Autonomous University of Mexico and the Salvador Zubirán National Institute of Health Sciences and Nutrition, Mexico City 14080, Mexico., Blanco E; Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, USA., Gahagan S; Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA 92093, USA., Cox NJ; Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hanis C; University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Butte NF; United States Department of Agriculture, Agricultural Research Service, The Children's Nutrition Research Center, and the Department Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Cole SA; Population Health Program, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Comuzzie AG; The Obesity Society, Silver Spring, MD 20910, USA., Voruganti VS; Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA., Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wang Y; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sofer T; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA., Ziv E; Division of General Internal Medicine, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94115, USA., Grant SFA; Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Ruiz-Linares A; Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200438, China.; Department of Genetics, Evolution and Environment, and Genetics Institute of the University College London, London WC1E 6BT, UK.; Laboratory of Biocultural Anthropology, Law, Ethics, and Health, Aix-Marseille University, Marseille 13385, France., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502 USA., Haiman CA; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Parra EJ; Department of Anthropology, University of Toronto- Mississauga, Mississauga, ON L5L 1C6, Canada., Cruz M; Medical Research Unit in Biochemistry, Specialty Hospital, National Medical Center of the Twenty-First Century, Mexican Institute of Social Security, Mexico City 06725, Mexico., Loos RJF; The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
المصدر: HGG advances [HGG Adv] 2022 Mar 11; Vol. 3 (2), pp. 100099. Date of Electronic Publication: 2022 Mar 11 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier Inc., [2020]-
مستخلص: Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.
Competing Interests: S.M.G. and A.M.S. receive funding from Seven Bridges Genomics to develop tools for the NHLBI BioData Catalyst consortium. All others authors declare no competing interests.
(© 2022 The Author(s).)
التعليقات: Erratum in: HGG Adv. 2022 Oct 11;4(1):100149. doi: 10.1016/j.xhgg.2022.100149. (PMID: 36268164)
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معلومات مُعتمدة: R01 HL143885 United States HL NHLBI NIH HHS; P30 AG066615 United States AG NIA NIH HHS; R01 HG009974 United States HG NHGRI NIH HHS; R01 DK119268 United States DK NIDDK NIH HHS; R00 HL130580 United States HL NHLBI NIH HHS; R01 HL142302 United States HL NHLBI NIH HHS; R01 HL088457 United States HL NHLBI NIH HHS; U01 CA261339 United States CA NCI NIH HHS; T32 HL129982 United States HL NHLBI NIH HHS; R01 CA063446 United States CA NCI NIH HHS; R01 CA204797 United States CA NCI NIH HHS; R01 HL060712 United States HL NHLBI NIH HHS; R01 HL149683 United States HL NHLBI NIH HHS; R01 HL113323 United States HL NHLBI NIH HHS; K99 HL130580 United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; R01 EY022651 United States EY NEI NIH HHS; F99 AG073565 United States AG NIA NIH HHS; P30 ES030285 United States ES NIEHS NIH HHS; R01 DK101855 United States DK NIDDK NIH HHS; R01 HD056465 United States HD NICHD NIH HHS; R01 EY014684 United States EY NEI NIH HHS; U01 HG011723 United States HG NHGRI NIH HHS; R01 HL140976 United States HL NHLBI NIH HHS; P01 HL045522 United States HL NHLBI NIH HHS; R01 DK089256 United States DK NIDDK NIH HHS; R01 DK118062 United States DK NIDDK NIH HHS; UL1 TR001855 United States TR NCATS NIH HHS; T32 HD091058 United States HD NICHD NIH HHS; R01 HD057194 United States HD NICHD NIH HHS; UL1 TR001881 United States TR NCATS NIH HHS; P2C HD050924 United States HD NICHD NIH HHS; T32 HL007055 United States HL NHLBI NIH HHS; R01 DK079888 United States DK NIDDK NIH HHS; R01 HG010297 United States HG NHGRI NIH HHS; U10 EY011753 United States EY NEI NIH HHS; R35 GM142783 United States GM NIGMS NIH HHS; R01 DK122503 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Hispanic/Latino; anthropometrics; diversity; fine-mapping; obesity; population stratification; trans-ancestral or trans-ethnic
تواريخ الأحداث: Date Created: 20220411 Latest Revision: 20240923
رمز التحديث: 20240923
مُعرف محوري في PubMed: PMC8990175
DOI: 10.1016/j.xhgg.2022.100099
PMID: 35399580
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-2477
DOI:10.1016/j.xhgg.2022.100099