دورية أكاديمية
Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival.
| العنوان: | Associations between Pre-Diagnostic Physical Activity with Breast Cancer Characteristics and Survival. |
|---|---|
| المؤلفون: | Lim ZL; Laboratory of Women's Health & Genetics, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Lim GH; Breast Department, KK Women's and Children's Hospital, Singapore 229899, Singapore.; Duke-NUS Medical School, Singapore 169857, Singapore., Ho PJ; Laboratory of Women's Health & Genetics, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore., Khng AJ; Laboratory of Women's Health & Genetics, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore., Yeoh YS; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Ong ATW; Department of Surgery, National University Hospital, Singapore 119054, Singapore., Tan BKT; Department of Breast Surgery, Singapore General Hospital, Singapore 168753, Singapore.; Department of General Surgery, Sengkang General Hospital, Singapore 544886, Singapore.; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Tan EY; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Tan SM; Division of Breast Surgery, Changi General Hospital, Singapore 529889, Singapore., Tan VK; Department of Breast Surgery, Singapore General Hospital, Singapore 168753, Singapore.; Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Li J; Laboratory of Women's Health & Genetics, Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Hartman M; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Department of Surgery, National University Hospital, Singapore 119054, Singapore. |
| المصدر: | Cancers [Cancers (Basel)] 2022 Mar 30; Vol. 14 (7). Date of Electronic Publication: 2022 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مستخلص: | Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA and the aggressiveness of BC is unclear. We investigated the associations between PA, BC tumour characteristics, and survival. This retrospective observational study included 7688 BC patients from the Singapore Breast Cancer Cohort (2010−2016). PA information from the questionnaire included intensity (light/moderate/vigorous) and duration (<1 h/1−2 h/>2 h per week). A PA score (1−5) incorporating intensity and duration was calculated. Associations between PA score and tumour characteristics such as stage, histological grade, nodal and hormone receptor status were examined using multinomial regression. Moreover, 10-year overall survival was estimated using Cox regression analysis in 6572 patients after excluding patients with invalid survival data and stage IV disease. Breast tumours associated with higher PA score were more likely to be non-invasive (ORinvasive vs. non-invasive(reference) [95% CI]: 0.71 [0.58−0.87], p-trend = 0.001), of lower grade (ORpoorly vs. well differentiated(reference): 0.69 [0.52−0.93], p = 0.014), ER-positive (ORER-negative vs. ER-positive(reference): 0.94 [0.89−1.00], p-trend = 0.049), PR-positive (ORPR-negative vs. PR-positive(reference): 0.82 [0.67−0.99], p = 0.041), HER2-negative (ORHER2-negative vs. HER2-positive(reference): 1.29 [1.02−1.62], p-trend = 0.002), and less likely to be of HER2-overexpressed subtype (ORHER2-overexpressed vs. Luminal A(reference): 0.89 [0.81−0.98], p-trend = 0.018). These associations (odds ratios) were more pronounced among post-menopausal patients. A higher PA score did not improve survival. Higher levels of pre-diagnostic PA were associated with less aggressive tumours in BC patients. This illustrated another benefit of PA in addition to its known role in BC risk reduction. |
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| معلومات مُعتمدة: | NRFF2017-02 National Research Foundation; Applied Translational Research Biomedical Research Council; NIL NUS Start-up Grant; [NMRC/CG/NCIS/2010, NMRC/CG/012/2013, CGAug16M005 National University Cancer Institute; Breast Cancer Prevention Program Saw Swee Hock School of Public Health Research Programme of Research Seed Funding; NIL Yong Loo Lin School of Medicine Breast Cancer Screening Prevention Programme; NIL Asian Breast Cancer Research Fund; NMRC/CSA-SI/0015/2017 National Medical Research Council |
| فهرسة مساهمة: | Keywords: breast cancer; cancer survival; physical activity; retrospective cohort study |
| تواريخ الأحداث: | Date Created: 20220412 Latest Revision: 20230308 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8997033 |
| DOI: | 10.3390/cancers14071756 |
| PMID: | 35406528 |
| قاعدة البيانات: | MEDLINE |
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