دورية أكاديمية
The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon.
| العنوان: | The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon. |
|---|---|
| المؤلفون: | Lopes FT; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., de Sousa RS; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Carvalho Gomes JL; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Vallinoto MC; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., de Lima ACR; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Lima SS; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Freitas FB; Virology Section, Evandro Chagas Institute, Ananindeua, Brazil., Feitosa RNM; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Rangel da Silva ANM; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Machado LFA; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Aben-Athar CYP; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Maia da Silva EL; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Cayres Vallinoto IMV; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Vallinoto ACR; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil. |
| المصدر: | Frontiers in public health [Front Public Health] 2022 Mar 28; Vol. 10, pp. 864861. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Editorial Office |
| مواضيع طبية MeSH: | HTLV-I Infections*/diagnosis , HTLV-I Infections*/epidemiology , HTLV-II Infections*/complications , HTLV-II Infections*/diagnosis , HTLV-II Infections*/epidemiology , Human T-lymphotropic virus 1*, Adult ; Brazil/epidemiology ; Counseling ; Female ; Human T-lymphotropic virus 2 ; Humans ; Male ; Middle Aged |
| مستخلص: | Introduction: To identify the prevalence of infection in the urban area of the capital city of Belém, Brazil, the Laboratory of Virology of the Federal University of Pará implemented, as a public service, serological screening for human T-lymphotropic viruses 1 and 2 (HTLV-1/2) infection and, if necessary, counseling service and referral to specialized medical care. The project is funded by the National Council of Science and Technology, the Ministry of Health of Brazil and the Pan American Health Organization. Methods: From January 2020 to June 2021, 1,572 individuals of both sexes were approached to answer a questionnaire and were tested using an enzyme immunoassay (Murex HTLV-I+II, DiaSorin, Dartford, UK). Seropositive samples were confirmed as HTLV-1 and HTLV-2 infection by line immunoassay (INNO-LIA ® HTLV I/II Score, Fujirebio, Japan) and/or by real-time polymerase chain reaction. G and Fisher's exact tests were applied to identify the association between epidemiological characteristics and HTLV-1/2 infection. Results: Of the 1,572 screened individuals, 63.74% were females between the ages of 30 and 59 years (49.04%). Infection was confirmed in six individuals (0.38%), among whom three (0.19%) were infected with HTLV-1 and three with HTLV-2 (0.19%). Blood transfusion before 1993 was the main risk factor associated with the route of exposure to the virus ( p = 0.0442). The infected individuals were referred to a counseling session with a nursing professional, and two patients who manifested signs and symptoms suggestive of myelopathy associated with HTLV were referred to a neurologist. Conclusion: The implementation of the screening service revealed the occurrence of moderate endemicity of HTLV-1/2 in Belém, reinforcing the importance of continuing the service as a means of establishing an early diagnosis and providing counseling as a measure to prevent and control viral transmission in the general population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lopes, de Sousa, Carvalho Gomes, Vallinoto, de Lima, Lima, Freitas, Feitosa, Rangel da Silva, Machado, Aben-Athar, Maia da Silva, Cayres Vallinoto and Vallinoto.) |
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| فهرسة مساهمة: | Keywords: Amazonia; Belém; HTLV-1; HTLV-2; epidemiology |
| تواريخ الأحداث: | Date Created: 20220414 Date Completed: 20220415 Latest Revision: 20231103 |
| رمز التحديث: | 20231103 |
| مُعرف محوري في PubMed: | PMC8995423 |
| DOI: | 10.3389/fpubh.2022.864861 |
| PMID: | 35419336 |
| قاعدة البيانات: | MEDLINE |
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