دورية أكاديمية
Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic.
| العنوان: | Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic. |
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| المؤلفون: | Kamidani S; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA., Garg S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Rolfes MA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Campbell AP; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Cummings CN; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Abt Associates, Rockville, Maryland, USA., Haston JC; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Openo KP; Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta, Georgia, USA.; Veterans Affairs Medical Center, Decatur, Georgia, USA., Fawcett E; Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta, Georgia, USA.; Veterans Affairs Medical Center, Decatur, Georgia, USA., Chai SJ; California Emerging Infections Program, Oakland, California, USA.; Field Services Branch, Division of State and Local Readiness, Center for Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Herlihy R; Colorado Department of Public Health and Environment, Denver, Colorado, USA., Yousey-Hindes K; Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA., Monroe ML; Maryland Department of Health, Baltimore, Maryland, USA., Kim S; Michigan Department of Health and Human Services, Lansing, Michigan, USA., Lynfield R; Minnesota Department of Health, St Paul, Minnesota, USA., Smelser C; New Mexico Department of Health, Santa Fe, New Mexico, USA., Muse A; New York State Department of Health, Albany, New York, USA., Felsen CB; New York State Emerging Infections Program, Center for Community Health and Prevention, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA., Billing L; Ohio Department of Health, Columbus, Ohio, USA., Thomas A; Oregon Health Authority, Portland, Oregon, USA., Talbot HK; Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Schaffner W; Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Risk I; Salt Lake County Health Department, Salt Lake City, Utah, USA., Anderson EJ; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta and Emory University, Atlanta, Georgia, USA.; Georgia Emerging Infections Program, Georgia Department of Public Health, Atlanta, Georgia, USA.; Veterans Affairs Medical Center, Decatur, Georgia, USA.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Nov 30; Vol. 75 (11), pp. 1930-1939. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Influenza, Human*/epidemiology , Influenza, Human*/therapy , Influenza A Virus, H1N1 Subtype* , Pneumonia*, Child ; Infant ; Humans ; Adolescent ; Seasons ; Hospitalization |
| مستخلص: | Background: Recent population-based data are limited regarding influenza-associated hospitalizations in US children. Methods: We identified children <18 years hospitalized with laboratory-confirmed influenza during 2010-2019 seasons, through the Centers for Disease Control and Prevention's Influenza Hospitalization Surveillance Network. Adjusted hospitalization and in-hospital mortality rates were calculated, and multivariable logistic regression was conducted to evaluate risk factors for pneumonia, intensive care unit (ICU) admission, mechanical ventilation, and death. Results: Over 9 seasons, adjusted influenza-associated hospitalization incidence rates ranged from 10 to 375 per 100 000 persons each season and were highest among infants <6 months old. Rates decreased with increasing age. The highest in-hospital mortality rates were observed in children <6 months old (0.73 per 100 000 persons). Over time, antiviral treatment significantly increased, from 56% to 85% (P < .001), and influenza vaccination rates increased from 33% to 44% (P = .003). Among the 13 235 hospitalized children, 2676 (20%) were admitted to the ICU, 2262 (17%) had pneumonia, 690 (5%) required mechanical ventilation, and 72 (0.5%) died during hospitalization. Compared with those <6 months of age, hospitalized children ≥13 years old had higher odds of pneumonia (adjusted odds ratio, 2.7 [95% confidence interval, 2.1-3.4], ICU admission (1.6 [1.3-1.9]), mechanical ventilation (1.6 [1.1-2.2]), and death (3.3 [1.2-9.3]). Conclusions: Hospitalization and death rates were greatest in younger children at the population level. Among hospitalized children, however, older children had a higher risk of severe outcomes. Continued efforts to prevent and attenuate influenza in children are needed. Competing Interests: Potential conflicts of interest. K. P. O. reports grants from Foundation for Atlanta Veterans Education and Research (FAVER) during the conduct of the study. K. Y. H. reports receiving grants from the CDC Emerging Infections Program (EIP) and receiving an hororarium for an invited lecture to the Biology Department at Western Connecticut State University regarding coronavirus disease 2019 (COVID-19) surveillance, outside the submitted work. M. L. M. reports grants and support for travel from the CDC EIP, during the conduct of the study. S. K. reports grants from the Michigan Department of Health and Human Services, during the conduct of the study (Council for State and Territorial Epidemiologists federal grant). R. L. reports grants from the CDC EIP cooperative agreement, during the conduct of the study; receiving royalties as coeditor for a book on infectious disease surveillance (donated to the Minnesota Department of Health); and serving as an associate editor for the American Academy of Pediatrics Red Book (proceeds also donated to the Minnesota Department of Health). C. S. reports receiving grants from New Mexico Department of Health, during the conduct of the study. E. A. reports receiving grants from Pfizer, Sanofi Pasteur, MedImmune, PaxVax, GlaxoSmithKline, Merck, Janssen, and Micron and personal fees from Pfizer, Sanofi Pasteur, and Medscape, outside the submitted work. His institution has also received funding from the National Institutes of Health to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. He also serves on a safety monitoring board for Kentucky BioProcessing and Sanofi Pasteur. L. B. reports receiving grants from the Council for State and Territorial Epidemiologists and the CDC, outside the submitted work (recipient of Epidemiology and Laboratory Capacity and Immunizations and Vaccines for Children grant funding from the CDC to support vaccine preventable disease epidemiology staffing). A. T. reports receiving grants from the CDC EIP cooperative agreement, during the conduct of the study. H. K. T. reports receiving grants from the CDC, during the conduct of the study. W. S. reports grants from the CDC EIP cooperative agreement, during the conduct of the study, and personal fees from VBI Vaccines, outside the submitted work. I. R. reports that her institution has received grants through the Influenza Hospitalization-Based Surveillance Project. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: epidemiology; influenza; pediatrics; vaccines |
| تواريخ الأحداث: | Date Created: 20220419 Date Completed: 20221202 Latest Revision: 20230115 |
| رمز التحديث: | 20230116 |
| DOI: | 10.1093/cid/ciac296 |
| PMID: | 35438769 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciac296 |