دورية أكاديمية
أعرض في EDS

The Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine Hair Dosimeter, DNA Adductomics Discovery, and Associations with Prostate Cancer Pathology Biomarkers.

التفاصيل البيبلوغرافية
العنوان: The Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine Hair Dosimeter, DNA Adductomics Discovery, and Associations with Prostate Cancer Pathology Biomarkers.
المؤلفون: Guo J, Koopmeiners JS, Walmsley SJ, Villalta PW, Yao L, Murugan P, Tejpaul R, Weight CJ; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States., Turesky RJ
المصدر: Chemical research in toxicology [Chem Res Toxicol] 2022 May 16; Vol. 35 (5), pp. 703-730. Date of Electronic Publication: 2022 Apr 21.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington Dc : American Chemical Society
Original Publication: Washington, DC : American Chemical Society, c1988-
مواضيع طبية MeSH: Prostatic Hyperplasia* , Prostatic Neoplasms*, Acrolein ; Biomarkers ; Carcinogens/analysis ; DNA ; DNA Adducts ; Hair/chemistry ; Humans ; Male ; Meat/adverse effects ; Meat/analysis ; Pyridines ; Radiation Dosimeters
مستخلص: Well-done cooked red meat consumption is linked to aggressive prostate cancer (PC) risk. Identifying mutation-inducing DNA adducts in the prostate genome can advance our understanding of chemicals in meat that may contribute to PC. 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP), a heterocyclic aromatic amine (HAA) formed in cooked meat, is a potential human prostate carcinogen. PhIP was measured in the hair of PC patients undergoing prostatectomy, bladder cancer patients under treatment for cystoprostatectomy, and patients treated for benign prostatic hyperplasia (BPH). PhIP hair levels were above the quantification limit in 123 of 205 subjects. When dichotomizing prostate pathology biomarkers, the geometric mean PhIP hair levels were higher in patients with intermediate and elevated-risk prostate-specific antigen values than lower-risk values <4 ng/mL ( p = 0.03). PhIP hair levels were also higher in patients with intermediate and high-risk Gleason scores ≥7 compared to lower-risk Gleason score 6 and BPH patients ( p = 0.02). PC patients undergoing prostatectomy had higher PhIP hair levels than cystoprostatectomy or BPH patients ( p = 0.02). PhIP-DNA adducts were detected in 9.4% of the patients assayed; however, DNA adducts of other carcinogenic HAAs, and benzo[ a ]pyrene formed in cooked meat, were not detected. Prostate specimens were also screened for 10 oxidative stress-associated lipid peroxidation (LPO) DNA adducts. Acrolein 1, N 2 -propano-2'-deoxyguanosine adducts were detected in 54.5% of the patients; other LPO adducts were infrequently detected. Acrolein adducts were not associated with prostate pathology biomarkers, although DNA adductomic profiles differed between PC patients with low and high-grade Gleason scores. Many DNA adducts are of unknown origin; however, dG adducts of formaldehyde and a series of purported 4-hydroxy-2-alkenals were detected at higher abundance in a subset of patients with elevated Gleason scores. The PhIP hair biomarker and DNA adductomics data support the paradigm of well-done cooked meat and oxidative stress in aggressive PC risk.
References: Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1301-10. (PMID: 20447922)
J Chromatogr. 1984 Jun 8;308:121-31. (PMID: 6746809)
Mod Pathol. 2004 Mar;17(3):292-306. (PMID: 14976540)
Cancer Res. 1998 Oct 1;58(19):4307-13. (PMID: 9766658)
Anal Biochem. 2008 Mar 1;374(1):163-72. (PMID: 18036548)
Chem Res Toxicol. 2019 Aug 19;32(8):1515-1527. (PMID: 31286759)
Cancer Res. 2007 Feb 1;67(3):1378-84. (PMID: 17264317)
Carcinogenesis. 2016 Jul;37(7):685-691. (PMID: 27207666)
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Mar 25;802(1):127-33. (PMID: 15036004)
Chem Res Toxicol. 1994 Jul-Aug;7(4):511-8. (PMID: 7981415)
Cancer Res. 1984 Mar;44(3):990-5. (PMID: 6318992)
Environ Mol Mutagen. 2013 Jan;54(1):1-7. (PMID: 23238808)
Carcinogenesis. 1986 Jul;7(7):1081-6. (PMID: 3719903)
Chem Res Toxicol. 2017 Dec 18;30(12):2130-2139. (PMID: 29120619)
J Epidemiol. 2011;21(6):447-58. (PMID: 21963789)
Anal Chem. 2020 Nov 3;92(21):14476-14483. (PMID: 33076659)
J Agric Food Chem. 2000 Apr;48(4):1160-6. (PMID: 10775366)
Oncotarget. 2014 Jun 15;5(11):3526-40. (PMID: 24939871)
Cancer Causes Control. 2014 Aug;25(8):1015-28. (PMID: 24890804)
Pigment Cell Res. 1996 Oct;9(5):265-70. (PMID: 9014213)
J Am Chem Soc. 2008 Aug 20;130(33):10898-906. (PMID: 18661996)
Am J Epidemiol. 2009 Nov 1;170(9):1165-77. (PMID: 19808637)
Anal Chem. 2021 Apr 27;93(16):6491-6500. (PMID: 33844920)
Anal Chem. 2016 Dec 20;88(24):12508-12515. (PMID: 28139123)
Mutat Res. 2007 Jun 15;630(1-2):14-9. (PMID: 17392018)
Chem Res Toxicol. 1999 Dec;12(12):1195-204. (PMID: 10604869)
Cancer Res. 2005 Dec 15;65(24):11779-84. (PMID: 16357191)
Int J Cancer. 2007 Sep 15;121(6):1319-24. (PMID: 17487839)
Cancer Res. 1997 Jan 15;57(2):195-8. (PMID: 9000552)
Neoplasia. 2006 Sep;8(9):708-15. (PMID: 16984728)
Chem Res Toxicol. 2007 Feb;20(2):263-76. (PMID: 17305409)
Chem Res Toxicol. 1995 Jan-Feb;8(1):148-56. (PMID: 7703359)
J Proteome Res. 2015 Aug 7;14(8):3322-35. (PMID: 26088811)
Int J Urol. 2013 Feb;20(2):150-60. (PMID: 22852773)
Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27. (PMID: 26667886)
Mutat Res. 2000 Apr;462(2-3):311-22. (PMID: 10767641)
Mol Nutr Food Res. 2008 Jan;52(1):7-25. (PMID: 18203133)
Food Chem Toxicol. 1998 Apr;36(4):289-97. (PMID: 9651045)
Chem Res Toxicol. 2003 Jul;16(7):893-900. (PMID: 12870892)
J Biol Chem. 2008 Jun 6;283(23):15545-9. (PMID: 18285329)
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):803-8. (PMID: 17416774)
Nucleic Acids Res. 2019 Feb 20;47(3):1268-1277. (PMID: 30517733)
Mol Nutr Food Res. 2005 Jul;49(7):648-55. (PMID: 15986387)
J Org Chem. 1977 Sep 30;42(20):3292-6. (PMID: 20490)
Anal Chem. 2009 Jan 15;81(2):809-19. (PMID: 19086795)
Trends Genet. 2001 Apr;17(4):214-21. (PMID: 11275327)
Rev Urol. 2002;4 Suppl 5:S3-S10. (PMID: 16986064)
Chem Res Toxicol. 2010 Sep 20;23(9):1442-8. (PMID: 20849149)
Chem Res Toxicol. 2000 Jul;13(7):565-74. (PMID: 10898588)
High Throughput. 2019 May 14;8(2):. (PMID: 31091740)
J Nutr Health Aging. 2001;5(2):75-9. (PMID: 11426286)
Food Chem Toxicol. 2017 Aug;106(Pt B):583-594. (PMID: 27693244)
Food Chem Toxicol. 2002 Aug;40(8):1131-7. (PMID: 12067575)
Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8. (PMID: 14973110)
Science. 2016 Nov 4;354(6312):618-622. (PMID: 27811275)
Cancer Res. 2000 Mar 15;60(6):1507-11. (PMID: 10749113)
Front Chem. 2019 Oct 24;7:658. (PMID: 31709223)
Nucleosides Nucleotides Nucleic Acids. 2008 Feb;27(2):103-9. (PMID: 18205065)
Cancer Res. 1994 Jan 1;54(1):89-94. (PMID: 8261468)
Nutr J. 2010 Nov 02;9:50. (PMID: 21044319)
Histopathology. 2012 Jan;60(1):199-215. (PMID: 22212087)
Mutagenesis. 2015 Nov;30(6):763-70. (PMID: 26443852)
Carcinogenesis. 2000 Sep;21(9):1683-9. (PMID: 10964100)
J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):155-68. (PMID: 11477514)
Epidemiol Rev. 2001;23(1):72-81. (PMID: 11588857)
Chem Res Toxicol. 2000 Nov;13(11):1165-73. (PMID: 11087439)
Chem Res Toxicol. 2010 Jul 19;23(7):1234-44. (PMID: 20443584)
Prostate Cancer Prostatic Dis. 2007;10(3):261-9. (PMID: 17224912)
Cancer Prev Res (Phila). 2012 Jul;5(7):963-72. (PMID: 22581815)
Cancer Lett. 2016 Feb 1;371(1):71-8. (PMID: 26582657)
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8241-6. (PMID: 22493262)
Nutr Cancer. 2011;63(4):525-37. (PMID: 21526454)
Cancer Sci. 2004 Apr;95(4):290-9. (PMID: 15072585)
Mutat Res. 1999 Mar 8;424(1-2):71-81. (PMID: 10064851)
Cancer Lett. 2002 Jan 25;175(2):141-6. (PMID: 11741741)
Prostate. 2000 Jan;42(1):56-66. (PMID: 10579799)
Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1557-63. (PMID: 26224797)
Mutat Res. 2000 Apr;462(2-3):219-26. (PMID: 10767633)
J Agric Food Chem. 2008 Jan 9;56(1):68-78. (PMID: 18069786)
Carcinogenesis. 1990 Aug;11(8):1287-92. (PMID: 2387014)
Chem Res Toxicol. 1992 Sep-Oct;5(5):691-7. (PMID: 1446011)
Mutat Res. 2002 Sep 30;506-507:225-31. (PMID: 12351162)
Food Chem Toxicol. 1994 Jul;32(7):595-603. (PMID: 8045472)
J Clin Oncol. 2009 Jul 20;27(21):3459-64. (PMID: 19433685)
Nature. 2020 Feb;578(7793):94-101. (PMID: 32025018)
Chem Res Toxicol. 2019 Sep 16;32(9):1850-1862. (PMID: 31361128)
Chem Res Toxicol. 2013 Jun 17;26(6):1014-22. (PMID: 23675611)
AIMS Genet. 2017 Apr 18;4(2):103-137. (PMID: 31435505)
Anal Chem. 2017 Nov 7;89(21):11728-11736. (PMID: 28977750)
Toxicol Sci. 2015 Jul;146(1):170-82. (PMID: 25904104)
J Biol Chem. 2001 Mar 23;276(12):9077-82. (PMID: 11054428)
Cancer Epidemiol Biomarkers Prev. 1999 May;8(5):439-45. (PMID: 10350440)
Cancer Lett. 2006 Aug 8;239(2):157-67. (PMID: 16154258)
Pharmacol Toxicol. 2002 Jun;90(6):333-7. (PMID: 12403055)
Chem Res Toxicol. 2007 Aug;20(8):1141-8. (PMID: 17676814)
Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):80-7. (PMID: 18199713)
Chem Res Toxicol. 1992 Jul-Aug;5(4):479-90. (PMID: 1391614)
Carcinogenesis. 1993 Nov;14(11):2313-8. (PMID: 8242861)
Cancer Res. 1995 Oct 15;55(20):4516-9. (PMID: 7553619)
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012 Aug;29(8):1202-11. (PMID: 22571725)
J Biol Chem. 1999 Sep 24;274(39):27433-8. (PMID: 10488075)
Sci Transl Med. 2017 Oct 18;9(412):. (PMID: 29046434)
Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):22-8. (PMID: 8628916)
Antioxid Redox Signal. 2006 May-Jun;8(5-6):993-1001. (PMID: 16771689)
Carcinogenesis. 1999 Aug;20(8):1591-5. (PMID: 10426812)
N Engl J Med. 2004 May 27;350(22):2292-4. (PMID: 15163780)
Mutat Res. 2000 Jul 20;452(1):101-21. (PMID: 10894896)
Toxicol Sci. 2015 Feb;143(2):242-55. (PMID: 25628402)
Mol Biosyst. 2012 Oct;8(10):2535-44. (PMID: 22610447)
Am J Cancer Res. 2014 Dec 15;5(1):191-200. (PMID: 25628930)
Nucleic Acids Res. 2011 Nov 1;39(20):8752-64. (PMID: 21764772)
Chem Res Toxicol. 2003 Feb;16(2):145-52. (PMID: 12588185)
Cell. 2019 May 2;177(4):821-836.e16. (PMID: 30982602)
Chem Res Toxicol. 2011 Aug 15;24(8):1169-214. (PMID: 21688801)
Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):830-7. (PMID: 14504191)
Medicine (Baltimore). 2019 Oct;98(40):e17451. (PMID: 31577771)
Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):910-4. (PMID: 7846077)
Mutat Res. 2007 Dec 1;625(1-2):83-93. (PMID: 17606272)
Chemistry. 2000 Jan;6(2):369-78. (PMID: 11931118)
Chem Res Toxicol. 2019 Feb 18;32(2):318-325. (PMID: 30644728)
Cancer Epidemiol Biomarkers Prev. 2013 Mar;22(3):356-64. (PMID: 23329727)
Chem Res Toxicol. 2010 Nov 15;23(11):1701-13. (PMID: 20964440)
Food Chem Toxicol. 2021 Jan;147:111855. (PMID: 33189884)
Chem Res Toxicol. 2011 Feb 18;24(2):159-61. (PMID: 21155545)
Mutat Res. 2005 Sep 4;577(1-2):284-92. (PMID: 15922369)
Eur Urol. 2016 Mar;69(3):428-35. (PMID: 26166626)
Mutat Res. 1999 Mar 8;424(1-2):83-95. (PMID: 10064852)
Nat Rev Cancer. 2008 Apr;8(4):268-78. (PMID: 18337732)
Carcinogenesis. 2012 Nov;33(11):2108-18. (PMID: 22822096)
J Agric Food Chem. 2012 Sep 12;60(36):9371-5. (PMID: 22906298)
Cancer Res. 1986 Nov;46(11):5682-6. (PMID: 3756915)
Int J Cancer. 2013 Aug 15;133(4):961-71. (PMID: 23400709)
IARC Monogr Eval Carcinog Risks Hum. 2006;88:1-478. (PMID: 17366697)
Carcinogenesis. 1992 Apr;13(4):629-35. (PMID: 1576716)
Lancet Oncol. 2015 Dec;16(16):1599-600. (PMID: 26514947)
Curr Metabolomics. 2013;1(1):92-107. (PMID: 26078916)
J Agric Food Chem. 2009 Apr 22;57(8):3173-9. (PMID: 19265446)
Chem Res Toxicol. 2009 Aug;22(8):1454-63. (PMID: 19588936)
Toxicol Sci. 2018 Jun 1;163(2):543-556. (PMID: 29596660)
Free Radic Biol Med. 1991;11(1):81-128. (PMID: 1937131)
Genes Environ. 2021 Jul 16;43(1):29. (PMID: 34271992)
Int J Environ Res Public Health. 2011 Jul;8(7):2675-91. (PMID: 21845152)
Chem Res Toxicol. 2005 Aug;18(8):1306-15. (PMID: 16097804)
Chem Res Toxicol. 2019 Nov 18;32(11):2156-2168. (PMID: 31549505)
Chem Res Toxicol. 2019 Nov 18;32(11):2153-2155. (PMID: 31509385)
Arch Toxicol. 2017 Aug;91(8):2813-2825. (PMID: 28011991)
Toxicol Sci. 2011 Mar;120 Suppl 1:S28-48. (PMID: 20881231)
Cancer Sci. 2021 Jan;112(1):7-15. (PMID: 32978845)
Cancer Res. 2007 Dec 1;67(23):11455-62. (PMID: 18056474)
Acta Med Indones. 2016 Jul;48(3):228-238. (PMID: 27840359)
Carcinogenesis. 2002 Oct;23(10):1721-7. (PMID: 12376482)
Br J Cancer. 2015 Feb 3;112(3):580-93. (PMID: 25422909)
PLoS One. 2011;6(11):e27711. (PMID: 22132129)
Cancer. 2004 Nov 15;101(10 Suppl):2371-490. (PMID: 15495199)
Chem Res Toxicol. 2009 Mar 16;22(3):511-7. (PMID: 19146376)
Food Chem Toxicol. 1998 Apr;36(4):279-87. (PMID: 9651044)
Mod Pathol. 2018 Jan;31(S1):S96-109. (PMID: 29297497)
Skin Appendage Disord. 2018 Oct;4(4):304-307. (PMID: 30410902)
Chem Res Toxicol. 2020 Apr 20;33(4):852-854. (PMID: 32223224)
N Engl J Med. 1996 Aug 1;335(5):345-6. (PMID: 8663860)
Toxicology. 2002 Dec 27;181-182:219-22. (PMID: 12505314)
Chem Res Toxicol. 2014 Mar 17;27(3):356-66. (PMID: 24437709)
معلومات مُعتمدة: U2C ES026533 United States ES NIEHS NIH HHS; R03 ES031188 United States ES NIEHS NIH HHS; P30 CA077598 United States CA NCI NIH HHS; R50 CA211256 United States CA NCI NIH HHS; UL1 TR000114 United States TR NCATS NIH HHS; R01 CA122320 United States CA NCI NIH HHS; R01 ES019564 United States ES NIEHS NIH HHS; R01 CA220367 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (Carcinogens)
0 (DNA Adducts)
0 (Pyridines)
7864XYD3JJ (Acrolein)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20220421 Date Completed: 20220517 Latest Revision: 20230517
رمز التحديث: 20230517
مُعرف محوري في PubMed: PMC9148444
DOI: 10.1021/acs.chemrestox.2c00012
PMID: 35446561
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-5010
DOI:10.1021/acs.chemrestox.2c00012