دورية أكاديمية
أعرض في EDS

Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.

التفاصيل البيبلوغرافية
العنوان: Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.
المؤلفون: Bosma KJ; Department of Veterans Affairs, Tennessee Valley Authority, Nashville, TN 37212, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Kaiser CE; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA., Kimple ME; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, University of Wisconsin-Madison, 4148 UW Medical Foundation Centennial Bldg., Madison, WI 53705, USA., Gannon M; Department of Veterans Affairs, Tennessee Valley Authority, Nashville, TN 37212, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.; Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center 2213 Garland Ave., 7465 MRB IV, Nashville, TN 37232-0475, USA.
المصدر: Metabolites [Metabolites] 2022 Apr 12; Vol. 12 (4). Date of Electronic Publication: 2022 Apr 12.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Arachidonic acid (AA) is a polyunsaturated 20-carbon fatty acid present in phospholipids in the plasma membrane. The three primary pathways by which AA is metabolized are mediated by cyclooxygenase (COX) enzymes, lipoxygenase (LOX) enzymes, and cytochrome P450 (CYP) enzymes. These three pathways produce eicosanoids, lipid signaling molecules that play roles in biological processes such as inflammation, pain, and immune function. Eicosanoids have been demonstrated to play a role in inflammatory, renal, and cardiovascular diseases as well type 1 and type 2 diabetes. Alterations in AA release or AA concentrations have been shown to affect insulin secretion from the pancreatic beta cell, leading to interest in the role of AA and its metabolites in the regulation of beta-cell function and maintenance of beta-cell mass. In this review, we discuss the metabolism of AA by COX, LOX, and CYP, the roles of these enzymes and their metabolites in beta-cell mass and function, and the possibility of targeting these pathways as novel therapies for treating diabetes.
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معلومات مُعتمدة: I01 BX003700 United States BX BLRD VA; I01 BX003744 United States BX BLRD VA; I01 BX005399 United States BX BLRD VA; R01 DK120626 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: arachidonic acid; beta-cell mass; eicosanoids; prostaglandins
تواريخ الأحداث: Date Created: 20220421 Latest Revision: 20230125
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9031745
DOI: 10.3390/metabo12040342
PMID: 35448529
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo12040342