دورية أكاديمية
Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors.
| العنوان: | Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors. |
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| المؤلفون: | Shehzad MT; Institute of Chemical Sciences, Bahauddin Zakariya University Multan 60800 Pakistan zahidshafiq@bzu.edu.pk., Imran A; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus Abbottabad 22060 Pakistan drjamshed@ciit.net.pk jamshediqb@googlemail.com., Hameed A; Department of Chemistry, Forman Christian College (A Chartered University) Ferozepur Road Lahore 54600 Pakistan.; Department of Chemistry, University of Sahiwal Sahiwal 57000 Pakistan., Rashida MA; Department of Chemistry, Forman Christian College (A Chartered University) Ferozepur Road Lahore 54600 Pakistan., Bibi M; Department of Biosciences, 90 and 100 Clifton, Shaheed Zulfikar Ali Bhutto Institute of Science and Technology Block 5, Clifton Karachi 75600 Pakistan., Uroos M; Institute of Chemistry, University of the Punjab Lahore 54590 Pakistan., Asari A; Faculty of Science and Marine Environment, Universiti Malaysia Terengganu 21030 Kuala Nerus Terengganu Malaysia., Iftikhar S; Department of Chemistry, University of Sahiwal Sahiwal 57000 Pakistan., Mohamad H; Institute of Marine Biotechnology, Universiti Malaysia Terengganu 21030 Kuala Nerus Terengganu Malaysia., Tahir MN; Department of Physics, University of Sargodha Sargodha Pakistan., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University Multan 60800 Pakistan zahidshafiq@bzu.edu.pk., Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus Abbottabad 22060 Pakistan drjamshed@ciit.net.pk jamshediqb@googlemail.com. |
| المصدر: | RSC advances [RSC Adv] 2021 May 11; Vol. 11 (28), pp. 17259-17282. Date of Electronic Publication: 2021 May 11 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]- |
| مستخلص: | Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a viable approach for the development of new antidiabetic agents. With our ongoing interest towards aldose reductase (ALR2) inhibition, we have synthesized and screened a series of thiazoline derivatives (5a-k, 6a-f, 7a-1 & 8a-j) to find a lead as a potential new antidiabetic agent. The bioactivity results showed the thiazoline-based compound 7b having a benzyl substituent and nitrophenyl substituent-bearing compound 8e were identified as the most potent molecules with IC Competing Interests: The authors declare no conflict of interest. (This journal is © The Royal Society of Chemistry.) |
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| تواريخ الأحداث: | Date Created: 20220428 Latest Revision: 20220430 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9033183 |
| DOI: | 10.1039/d1ra01716k |
| PMID: | 35479726 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2046-2069 |
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| DOI: | 10.1039/d1ra01716k |