دورية أكاديمية
أعرض في EDS

Sarcopenic visceral obesity is associated with increased post-liver transplant mortality in acutely ill patients with cirrhosis.

التفاصيل البيبلوغرافية
العنوان: Sarcopenic visceral obesity is associated with increased post-liver transplant mortality in acutely ill patients with cirrhosis.
المؤلفون: Ha NB; Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, California, USA., Montano-Loza AJ; Division of Gastroenterology and Liver Unit, Department of Medicine, University of Alberta, Edmonton, AB, Canada., Carey EJ; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Scottsdale, Arizona, USA., Lin S; 3D Lab, Center for Intelligent Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA., Shui AM; Biostatistics Core, Department of Surgery, University of California, San Francisco, California, USA., Huang CY; Biostatistics Core, Department of Surgery, University of California, San Francisco, California, USA., Dunn MA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lai JC; Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, California, USA.; Liver Center, University of California, San Francisco, California, USA.
المصدر: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Sep; Vol. 22 (9), pp. 2195-2202. Date of Electronic Publication: 2022 May 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier
Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
مواضيع طبية MeSH: Liver Neoplasms*/pathology , Liver Transplantation* , Sarcopenia*/complications, Adult ; Female ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Male ; Muscle, Skeletal/pathology ; Obesity/complications ; Obesity, Abdominal/complications ; Retrospective Studies ; Risk Factors
مستخلص: "Sarcopenic obesity" refers to a condition of low muscle mass in the context of obesity, though may be difficult to assess in patients with cirrhosis who are acutely ill. We aimed to define sarcopenic visceral obesity (SVO) using CT-based skeletal muscle index (SMI) and visceral-to-subcutaneous adipose tissue ratio (VSR) to examine its association with post-transplant mortality. We analyzed 116 adult inpatients with cirrhosis who were urgently listed and transplanted between 1/2005 and 12/2017 at 4 North American transplant centers. SVO was defined as patients with sarcopenia (SMI <50 cm 2 /m 2 in men and <39 cm 2 /m 2 in women) and visceral obesity (VSR ≥ 1.54 in men and ≥1.37 in women). The percentage who met criteria for sarcopenia, visceral obesity, and SVO were 45%, 42%, and 20%, respectively. Cumulative rates of post-transplant mortality were higher in patients with SVO compared to patients with sarcopenia or visceral obesity alone at 36 months (39% vs. 14% vs. 8%) [logrank p = .01]. In univariable regression, SVO was associated with post-transplant mortality (HR 2.92, 95%CI 1.04-8.23) and remained significant after adjusting for age, sex, diabetes, encephalopathy, hepatocellular carcinoma, and MELD-Na (HR 3.50, 95%CI 1.10-11.15). In conclusion, SVO is associated with increased post-transplant mortality in acutely ill patients with cirrhosis.
(© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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معلومات مُعتمدة: T32 DK060414 United States DK NIDDK NIH HHS; R01 AG059183 United States AG NIA NIH HHS; P30 DK026743 United States DK NIDDK NIH HHS; R21 AG067554 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: body composition; skeletal muscle mass; subcutaneous adipose tissue; visceral adipose tissue; visceral-to-subcutaneous adipose tissue ratio
تواريخ الأحداث: Date Created: 20220429 Date Completed: 20220831 Latest Revision: 20230902
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9427718
DOI: 10.1111/ajt.17079
PMID: 35486028
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-6143
DOI:10.1111/ajt.17079