دورية أكاديمية
Conflict Detection in a Sequential Decision Task Is Associated with Increased Cortico-Subthalamic Coherence and Prolonged Subthalamic Oscillatory Response in the β Band.
| العنوان: | Conflict Detection in a Sequential Decision Task Is Associated with Increased Cortico-Subthalamic Coherence and Prolonged Subthalamic Oscillatory Response in the β Band. |
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| المؤلفون: | Patai EZ; Medical Research Council Brain Network Dynamics Unit, Oxford University, Oxford OX1 3TH, United Kingdom.; Wellcome Centre for Human Neuroimaging, University College London Queen Square Institute of Neurology, London WC1N 3AR, United Kingdom.; Department of Psychology, School of Biological and Behavioral Sciences, Queen Mary University, London E1 4NS, United Kingdom., Foltynie T; Functional Neurosurgery Unit, The National Hospital for Neurology and Neurosurgery and Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom., Limousin P; Functional Neurosurgery Unit, The National Hospital for Neurology and Neurosurgery and Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom., Akram H; Functional Neurosurgery Unit, The National Hospital for Neurology and Neurosurgery and Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom., Zrinzo L; Functional Neurosurgery Unit, The National Hospital for Neurology and Neurosurgery and Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London WC1N 3BG, United Kingdom., Bogacz R; Medical Research Council Brain Network Dynamics Unit, Oxford University, Oxford OX1 3TH, United Kingdom rafal.bogacz@ndcn.ox.ac.uk., Litvak V; Wellcome Centre for Human Neuroimaging, University College London Queen Square Institute of Neurology, London WC1N 3AR, United Kingdom. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2022 Jun 08; Vol. 42 (23), pp. 4681-4692. Date of Electronic Publication: 2022 May 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Deep Brain Stimulation*/methods , Motor Cortex*/physiology , Parkinson Disease*/therapy , Subthalamic Nucleus*/physiology, Beta Rhythm ; Female ; Humans ; Magnetoencephalography ; Male |
| مستخلص: | Making accurate decisions often involves the integration of current and past evidence. Here, we examine the neural correlates of conflict and evidence integration during sequential decision-making. Female and male human patients implanted with deep-brain stimulation (DBS) electrodes and age-matched and gender-matched healthy controls performed an expanded judgment task, in which they were free to choose how many cues to sample. Behaviorally, we found that while patients sampled numerically more cues, they were less able to integrate evidence and showed suboptimal performance. Using recordings of magnetoencephalography (MEG) and local field potentials (LFPs; in patients) in the subthalamic nucleus (STN), we found that β oscillations signaled conflict between cues within a sequence. Following cues that differed from previous cues, β power in the STN and cortex first decreased and then increased. Importantly, the conflict signal in the STN outlasted the cortical one, carrying over to the next cue in the sequence. Furthermore, after a conflict, there was an increase in coherence between the dorsal premotor cortex and STN in the β band. These results extend our understanding of cortico-subcortical dynamics of conflict processing, and do so in a context where evidence must be accumulated in discrete steps, much like in real life. Thus, the present work leads to a more nuanced picture of conflict monitoring systems in the brain and potential changes because of disease. SIGNIFICANCE STATEMENT Decision-making often involves the integration of multiple pieces of information over time to make accurate predictions. We simultaneously recorded whole-head magnetoencephalography (MEG) and local field potentials (LFPs) from the human subthalamic nucleus (STN) in a novel task which required integrating sequentially presented pieces of evidence. Our key finding is prolonged β oscillations in the STN, with a concurrent increase in communication with frontal cortex, when presented with conflicting information. These neural effects reflect the behavioral profile of reduced tendency to respond after conflict, as well as relate to suboptimal cue integration in patients, which may be directly linked to clinically reported side-effects of deep-brain stimulation (DBS) such as impaired decision-making and impulsivity. (Copyright © 2022 Patai et al.) |
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| معلومات مُعتمدة: | MC_UU_12024/5 United Kingdom MRC_ Medical Research Council; MC_UU_00003/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; BB/S006338/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 203147/Z/16/Z United Kingdom WT_ Wellcome Trust; MR/K005464/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: DBS; coherence; conflict; dorsal premotor cortex; evidence integration; human; subthalamic nucleus |
| تواريخ الأحداث: | Date Created: 20220502 Date Completed: 20220610 Latest Revision: 20240401 |
| رمز التحديث: | 20240402 |
| مُعرف محوري في PubMed: | PMC9186803 |
| DOI: | 10.1523/JNEUROSCI.0572-21.2022 |
| PMID: | 35501153 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.0572-21.2022 |