دورية أكاديمية
KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV-1 in serodiscordant couples in Burkina Faso.
العنوان: | KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV-1 in serodiscordant couples in Burkina Faso. |
---|---|
المؤلفون: | Lallogo TD; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Djigma FW; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Sorgho PA; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Martinson JJ; Laboratory of Infectious Diseases/Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Compaore TR; Institute for Research in Health Sciences, IRSS, Ouagadougou, Burkina Faso., Traore L; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Bado P; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Bazie BVEJT; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Amegnona LJ; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Kagone TS; National Institute of Public Health, Bobo-Dioulasso, Burkina Faso., Ouedraogo RA; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Ilboudo DP; University of Fada N'Gourma, N'Gourma, Burkina Faso., Obiri-Yeboah D; Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana., Yonli AT; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Simpore J; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso. |
المصدر: | Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4425-4432. Date of Electronic Publication: 2022 May 12. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
مواضيع طبية MeSH: | HIV Infections*/genetics , HIV Infections*/prevention & control , HLA-DRB1 Chains*/genetics , Receptors, KIR2DL5*/genetics, Alleles ; Burkina Faso ; Gene Frequency ; Genetic Predisposition to Disease ; HIV-1 ; HLA Antigens ; Haplotypes ; Humans |
مستخلص: | The human immunodeficiency virus (HIV) belongs to the Retroviridae family and remains a public health problem in sub-Saharan Africa. Recent reports from WHO have shown that 33 million people died from HIV infections. HIV is one of the most serious fatal human diseases of the 20th and 21st centuries. However, variations in genetic and immunological factors are associated with protection against HIV infection in uninfected people exposed to HIV. This is the case with naturals killers which play an important role in the progression or regression of HIV infection. The objective of this study is to characterize certain HLA (human leukocyte antigen) class II genes and KIR genes in HIV-1 serodiscordant couples in Burkina Faso. This study was carried out at Burkina Faso among nineteen (19) HIV-1 serodiscordant couples. Classical multiplex PCR (SSP-PCR) was used to characterize the presence or absence of the KIR genes and certain class II HLAs (DRB1*11 and DRB1*12). The characterization of the KIR and HLA genes DRB1*11, DRB1*12 in this study demonstrated that the inhibitor KIR2DL5B, would confer protection against HIV-1 infection in seronegative partners (odd ratio [OR] = 0.13 [0.02-0.72] and p = 0.029), and the HLA DRB1*12 allele was associated with protection against HIV-1 infection in seronegative partners (OR = 0.16 [0.03-0.77] and p = 0.038). AA and Bx haplotypes were not found to be associated with HIV-1 infection in serodiscordant couples. This study confirms the involvement of the KIR genes in viral pathologies such as HIV-1 infection. Future larger-scale studies may provide a better understanding of the molecular mechanism by which the KIR haplotype and combination of KIR/HLA are associated with protection against HIV infection. (© 2022 Wiley Periodicals LLC.) |
References: | UNAIDS. Focus on Burkina Faso [WWW Document]. 2017. Accessed March 19, 2021. https://www.unaids.org/fr/20190402_country_focus_BurkinaFaso. Miyazawa M, Lopalco L, Mazzotta F, Lo Caputo, S, Veas, F, Clerici M. The “immunologic advantage” of HIV-exposed seronegative individuals. AIDS. 2009;23:161-175. Kagoné TS, Bisseye C, Méda N, et al. A variant of DC-SIGN gene promoter associated with resistance to HIV-1 in serodiscordant couples in Burkina Faso. Asian Pac J Trop Med. 2014;7s1:S93-S96. Sorgho PA, Djigma FW, Martinson JJ, et al. Role of killer cell immunoglobulin-like receptors (KIR) genes in stages of HIV-1 infection among patients from Burkina Faso. Biomol Concepts. 2019;10:226-236. Zwolińska K, Błachowicz O, Tomczyk T, et al. The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population. Immunogenetics. 2016;68:327-337. Boulet S, Sharafi S, Simic N, et al. Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals. AIDS. 2008;22:595-599. Martin MP, Gao X, Lee JH, et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002;31:429-434. Jennes W, Verheyden S, Demanet C, et al. Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands. J Immunol. 2006;177:6588-6592. Ravet S, Scott-Algara D, Bonnet E, et al. Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals. Blood. 2007;109:4296-4305. Caligiuri MA. Human natural killer cells. Blood. 2008;112:461-469. Campbell KS, Purdy AK. Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology. 2011;132:315-325. Salim PH, Jobim M, Bredemeier M, et al. Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis. Clin Exp Immunol. 2010;160:325-330. Robinson J, Halliwell JA, Mcwilliam H, Lopez R, Marsh SG. IPD-the immuno polymorphism database. Nucleic Acids Res. 2013;41:D1234-D1240. Uhrberg M, Parham P, Wernet P. Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. Immunogenetics. 2002;54:221-229. Ashouri E, Farjadian S, Reed EF, ghaderi A, Rajalingam R. KIR gene content diversity in four Iranian populations. Immunogenetics. 2009;61:483-492. Mcqueen KL, Dorighi KM, Guethlein LA, Wong R, Sanjanwala B, Parham P. Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. Hum Immunol. 2007;68:309-323. Carrington M, O'brien SJ. The influence of HLA genotype on AIDS. Annu Rev Med. 2003;54:535-551. Macdonald KS, Fowke KR, Kimani J, et al. Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. J Infect Dis. 2000;181:1581-1589. Chen Y, Winchester R, Korber B, et al. Influence of HLA alleles on the rate of progression of vertically transmitted HIV infection in children: association of several HLA-DR13 alleles with long-term survivorship and the potential association of HLA-A*2301 with rapid progression to AIDS. Long-term survivor study. Hum Immunol. 1997;55:154-162. Hendel H, Caillat-Zucman S, Lebuanec H, et al. New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS. J Immunol. 1999;162:6942-6946. Kaslow RA. Host genes and HIV infection: implications and applications. Emerg Infect Dis. 1997;3:401-402. Malhotra U, Holte S, Dutta S, et al. Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment. J Clin Invest. 2001;107:505-517. Kulkarni S, Martin MP, Carrington M. KIR genotyping by multiplex PCR-SSP. Methods Mol Biol. 2010;612:365-375. Chavan VR, Chaudhari D, Ahir S, Ansari Z, Mehta P, Mania-Pramanik J. Variations in KIR genes: a study in HIV-1 serodiscordant couples. BioMed Res Int. 2014;2014:891402. Shisana O, Rice K, Zungu N, Zuma K. Gender and poverty in South Africa in the era of HIV/AIDS: a quantitative study. J Womens Health (Larchmt). 2010;19:39-46. De Vincentis, S, Tartaro, G, Rochira V, Santi D. HIV and sexual dysfunction in men. J Clin Med. 2021;10:10. Compaore TR, Soubeiga ST, Ouattara AK, et al. APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso. PLoS One. 2016;11(1):e0146386. doi:10.1371/journal.pone.0146386. Compaore TR, Soubeiga ST, Ouattara AK, et al. APOBEC3G expression and HIV-1 infection in Burkina Faso. J Public Health Afr. 2018;9:907. Sorgho PA, Martinson JJ, Djigma FW, et al. Insights into the Interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso. Mediterr J Hematol Infect Dis. 2018;10:e2018060. Zouré AA, Amegnona LJ, Zongo N, et al. Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso. Open Life Sci. 2021;16:1101-1110. Santin I, Castellanos-Rubio A, Perez De Nanclares G, Vitoria JC, Castaño L, Bilbao JR. Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4. Genes Immun. 2007;8:171-176. Chavan VR, Ahir S, Ansari Z, et al. Diversity in KIR gene repertoire in HIV-1 exposed infected and uninfected infants: a study from India. J Med Virol. 2016;88:417-425. Jiang Y, Chen O, Cui C, et al. KIR3DS1/L1 and HLA-Bw4-80I are associated with HIV disease progression among HIV typical progressors and long-term nonprogressors. BMC Infect Dis. 2013;13:405. Merino A, Malhotra R, Morton M, et al. Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples. J Infect Dis. 2011;203:487-495. Lu Z, Zhang B, Chen S, et al. Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population. Cell Mol Immunol. 2008;5:457-463. Bejrachandra S, Kitayaporn D, Kaewkungwal J, et al. HLA class II (DRB1, DQA1 and DQB1) allele and haplotype frequencies among HIV-infection discordant Thai couples. Asian Pac J Allergy Immunol. 2004;22:143-151. |
فهرسة مساهمة: | Keywords: HIV; HLA-DRB1*11 and DRB1*12; KIR; multiplex PCR |
المشرفين على المادة: | 0 (HLA Antigens) 0 (HLA-DRB1 Chains) 0 (KIR2DL5B protein, human) 0 (Receptors, KIR2DL5) |
تواريخ الأحداث: | Date Created: 20220502 Date Completed: 20220715 Latest Revision: 20220925 |
رمز التحديث: | 20221213 |
DOI: | 10.1002/jmv.27821 |
PMID: | 35501290 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-9071 |
---|---|
DOI: | 10.1002/jmv.27821 |