دورية أكاديمية
KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV-1 in serodiscordant couples in Burkina Faso.
| العنوان: | KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV-1 in serodiscordant couples in Burkina Faso. |
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| المؤلفون: | Lallogo TD; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Djigma FW; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Sorgho PA; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Martinson JJ; Laboratory of Infectious Diseases/Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Compaore TR; Institute for Research in Health Sciences, IRSS, Ouagadougou, Burkina Faso., Traore L; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Bado P; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Bazie BVEJT; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Amegnona LJ; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Kagone TS; National Institute of Public Health, Bobo-Dioulasso, Burkina Faso., Ouedraogo RA; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Ilboudo DP; University of Fada N'Gourma, N'Gourma, Burkina Faso., Obiri-Yeboah D; Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana., Yonli AT; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso., Simpore J; Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso. |
| المصدر: | Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4425-4432. Date of Electronic Publication: 2022 May 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | HIV Infections*/genetics , HIV Infections*/prevention & control , HLA-DRB1 Chains*/genetics , Receptors, KIR2DL5*/genetics, Alleles ; Burkina Faso ; Gene Frequency ; Genetic Predisposition to Disease ; HIV-1 ; HLA Antigens ; Haplotypes ; Humans |
| مستخلص: | The human immunodeficiency virus (HIV) belongs to the Retroviridae family and remains a public health problem in sub-Saharan Africa. Recent reports from WHO have shown that 33 million people died from HIV infections. HIV is one of the most serious fatal human diseases of the 20th and 21st centuries. However, variations in genetic and immunological factors are associated with protection against HIV infection in uninfected people exposed to HIV. This is the case with naturals killers which play an important role in the progression or regression of HIV infection. The objective of this study is to characterize certain HLA (human leukocyte antigen) class II genes and KIR genes in HIV-1 serodiscordant couples in Burkina Faso. This study was carried out at Burkina Faso among nineteen (19) HIV-1 serodiscordant couples. Classical multiplex PCR (SSP-PCR) was used to characterize the presence or absence of the KIR genes and certain class II HLAs (DRB1*11 and DRB1*12). The characterization of the KIR and HLA genes DRB1*11, DRB1*12 in this study demonstrated that the inhibitor KIR2DL5B, would confer protection against HIV-1 infection in seronegative partners (odd ratio [OR] = 0.13 [0.02-0.72] and p = 0.029), and the HLA DRB1*12 allele was associated with protection against HIV-1 infection in seronegative partners (OR = 0.16 [0.03-0.77] and p = 0.038). AA and Bx haplotypes were not found to be associated with HIV-1 infection in serodiscordant couples. This study confirms the involvement of the KIR genes in viral pathologies such as HIV-1 infection. Future larger-scale studies may provide a better understanding of the molecular mechanism by which the KIR haplotype and combination of KIR/HLA are associated with protection against HIV infection. (© 2022 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: HIV; HLA-DRB1*11 and DRB1*12; KIR; multiplex PCR |
| المشرفين على المادة: | 0 (HLA Antigens) 0 (HLA-DRB1 Chains) 0 (KIR2DL5B protein, human) 0 (Receptors, KIR2DL5) |
| تواريخ الأحداث: | Date Created: 20220502 Date Completed: 20220715 Latest Revision: 20220925 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/jmv.27821 |
| PMID: | 35501290 |
| قاعدة البيانات: | MEDLINE |
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