دورية أكاديمية
Establishment of the LNCaP Cell Line - The Dawn of an Era for Prostate Cancer Research.
| العنوان: | Establishment of the LNCaP Cell Line - The Dawn of an Era for Prostate Cancer Research. |
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| المؤلفون: | Abate-Shen C; Department of Molecular Pharmacology and Therapeutics, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Nunes de Almeida F; Department of Molecular Pharmacology and Therapeutics, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York. |
| المصدر: | Cancer research [Cancer Res] 2022 May 03; Vol. 82 (9), pp. 1689-1691. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Prostate*/pathology , Prostatic Neoplasms*/pathology, Androgens ; Cell Line ; Cell Transformation, Neoplastic ; Humans ; Male |
| مستخلص: | Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the treatment of patients with prostate cancer. See related article by Horoszewicz and colleagues, Cancer Res 1983;43:1809-18. (©2022 American Association for Cancer Research.) |
| References: | Prostate. 2003 Nov 1;57(3):205-25. (PMID: 14518029) Int J Cancer. 1998 Sep 11;77(6):887-94. (PMID: 9714059) Cancer Res. 1983 Apr;43(4):1809-18. (PMID: 6831420) Cancer Discov. 2021 Sep;11(9):2316-2333. (PMID: 33893149) Nat Med. 2004 Jan;10(1):33-9. (PMID: 14702632) Cancer Res. 2010 Apr 15;70(8):3089-97. (PMID: 20395202) Cell. 2013 Dec 5;155(6):1309-22. (PMID: 24315100) Urol Oncol. 1997 Mar-Apr;3(2):67-75. (PMID: 21227062) Int J Cancer. 1994 May 1;57(3):406-12. (PMID: 8169003) Science. 2009 May 8;324(5928):787-90. (PMID: 19359544) |
| معلومات مُعتمدة: | P01 CA265768 United States CA NCI NIH HHS; R01 CA173481 United States CA NCI NIH HHS; R01 CA183929 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Androgens) |
| تواريخ الأحداث: | Date Created: 20220503 Date Completed: 20220504 Latest Revision: 20230916 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9153264 |
| DOI: | 10.1158/0008-5472.CAN-22-1065 |
| PMID: | 35502546 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1538-7445 |
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| DOI: | 10.1158/0008-5472.CAN-22-1065 |