دورية أكاديمية
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Pragmatism in Pediatric Neurosurgery: More Than a Pipe Dream? A Systematic Literature Review and Analysis.

التفاصيل البيبلوغرافية
العنوان: Pragmatism in Pediatric Neurosurgery: More Than a Pipe Dream? A Systematic Literature Review and Analysis.
المؤلفون: Kik CC; Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands., Spoor JKH; Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: j.spoor@erasmusmc.nl.
المصدر: World neurosurgery [World Neurosurg] 2022 May; Vol. 161, pp. 418-423.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101528275 Publication Model: Print Cited Medium: Internet ISSN: 1878-8769 (Electronic) Linking ISSN: 18788750 NLM ISO Abbreviation: World Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier
مواضيع طبية MeSH: Neurosurgery*, Child ; Databases, Factual ; Humans ; Neurosurgical Procedures ; PubMed
مستخلص: Background: Classic randomized controlled trials (RCTs) form the cornerstone for medical guidelines and protocols. However, in neurosurgery, RCTs are not always applicable to everyday clinical practice. Pragmatic controlled trials aim to incorporate real-life data with the preservation of the methodologic quality. This study is a systematic literature review of all pediatric neurosurgical RCTs published between 2000 and 2020 and an analysis of their pragmatism.
Methods: An electronic database search was performed in PubMed, EMBASE, and the Cochrane Library to identify all relevant trials. Pragmatism was evaluated retrospectively on 9 domains: eligibility, recruitment, setting, organization, flexibility (delivery and adherence), follow-up, primary outcome, and primary analysis.
Results: Of the 1862 studies included, 15 met the inclusion criteria. On average, studies scored between equally pragmatic/explanatory and rather pragmatic (M = 3.59, standard deviation [SD] = 0.56). Lowest ratings were seen for setting (M = 2.80, SD = 1.66) and eligibility (M = 3.20, SD = 1.66). Highest scores of pragmatism were given to analysis (M = 4.67, SD = 0.82) and intervention organization (M = 4.60, SD = 1.06). There was no significant difference between studies based on number of patients included, main subject, or publication year.
Conclusions: Pediatric neurosurgical RCTs scored reasonably well on overall pragmatism. In the future, there will be a greater need for pragmatic controlled trials in pediatric neurosurgery to bridge the divide between real-life data and reliable methodological quality. There is an opportunity to develop further applications of pragmatism tailored to surgical interventions.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Neurosurgery; Pragmatic clinical trial; Randomized controlled trial
تواريخ الأحداث: Date Created: 20220504 Date Completed: 20220505 Latest Revision: 20220824
رمز التحديث: 20240628
DOI: 10.1016/j.wneu.2021.09.124
PMID: 35505562
قاعدة البيانات: MEDLINE
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