دورية أكاديمية
Factors related to the suppression of the antitumour immune response in female dogs with inflammatory mammary carcinoma.
| العنوان: | Factors related to the suppression of the antitumour immune response in female dogs with inflammatory mammary carcinoma. |
|---|---|
| المؤلفون: | Damasceno KA; Laboratory of Experimental Pathology, Gonçalo Moniz Institute, Salvador, Bahia, Brazil.; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil., Santos-Conceição AMD; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil.; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil., Silva LP; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil.; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil., Cardoso TMS; Laboratory of Clinical Research, Gonçalo Moniz Institute, Salvador, Bahia, Brazil., Vieira-Filho CHDC; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil., Figuerêdo SHS; Laboratory of Experimental Pathology, Gonçalo Moniz Institute, Salvador, Bahia, Brazil., Martins-Filho E; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil.; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil., Faria BGO; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil., Costa-Neto JMD; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil.; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil., Cassali GD; Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Estrela-Lima A; Research Center on Mammary Oncology NPqOM/HOSPMEV, Federal University of Bahia, Salvador, Bahia, Brazil.; Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia, Salvador, Bahia, Brazil. |
| المصدر: | PloS one [PLoS One] 2022 May 05; Vol. 17 (5), pp. e0267648. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Carcinoma*/pathology , Dog Diseases*/pathology , Inflammatory Breast Neoplasms* , Mammary Neoplasms, Animal*/pathology, Animals ; Dogs ; Female ; Humans ; Immunity ; Tumor Microenvironment |
| مستخلص: | Inflammatory mammary carcinoma (IMC), a neoplasia affecting women and female dogs, is considered an aggressive cancer with high metastatic potential and a low survival rate. Studies focused on the tumour microenvironment indicate that the aggressive behaviour of this tumour is primarily correlated with immunological factors as well as inflammation. The objective of this study was to analyse the possible strategies used by the tumour cells to suppress the immune response in female dogs with IMC. Forty-six female dogs were divided into three groups: control (C, n = 10), IMC (n = 14) and mammary carcinoma (MC, n = 22). Clinical-pathological evaluations, survival at follow-up, immunophenotyping of leukocytes in peripheral blood and tumours, and immunohistochemical evaluation of CD4+, granzyme B, perforin and FAS-L were performed. Clinical and pathological results showed a higher frequency of the primary form of neoplasia, solid arrays of tumor cells and a lower survival rate in the IMC group (30 days). Morphometric analysis of inflammatory infiltrate revealed more lymphocytes and macrophages in the IMC group. Immunophenotyping analysis of peripheral blood revealed a higher frequency of CD8+ T-cells (p = 0.0017), a lower frequency of CD4+ T-cells (p <0.0001), and significantly higher mean MHCI and MHCII CD14+ fluorescence intensity in the IMC group (p = 0.038 and p = 0.0117, respectively). The immunohistochemical evaluation of tumour sections showed fewer FAS-L-positive inflammatory cells in the IMC group. These results suggest the important contribution of CD8+ T-cells, macrophages and FAS-L in the aggressiveness of IMC. Competing Interests: The authors have declared that no competing interests exist. |
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| تواريخ الأحداث: | Date Created: 20220505 Date Completed: 20220509 Latest Revision: 20220716 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9071162 |
| DOI: | 10.1371/journal.pone.0267648 |
| PMID: | 35512031 |
| قاعدة البيانات: | MEDLINE |
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