دورية أكاديمية
أعرض في EDS

Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.

التفاصيل البيبلوغرافية
العنوان: Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.
المؤلفون: Islam R; Research, Faisalabad Medical University, Faisalabad, PAK., Kundu S; Research, R.G. Kar Medical College, Kolkata, IND., Jha SB; Research, Jinan University School of Medicine, Guangzhou, CHN., Rivera AP; Research, Universidad Americana (UAM) Facultad de Medicina, Managua, NIC., Flores Monar GV; Research, Universidad Central del Ecuador, Quito, ECU., Islam H; Research, Faisalabad Medical University, Faisalabad, PAK., Puttagunta SM; Research, Dr Pinnamaneni Siddhartha Institute of Medical Sciences, Chinoutpalli, IND., Sange I; Research, K. J. Somaiya Medical College, Hospital and Research Center, Mumbai, IND.
المصدر: Cureus [Cureus] 2022 Apr 03; Vol. 14 (4), pp. e23785. Date of Electronic Publication: 2022 Apr 03 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Cirrhosis is an end-stage liver disease that can cause changes in any component of the hemostatic system. The net effects of the complicated hemostatic changes have long been unknown due to concurrent changes in pro-and antihemostatic drivers. Coagulation disorders are caused by various factors, including decreased clotting and inhibitor factor synthesis, reduced clearance of activated factors, quantitative and qualitative platelet defects, hyperfibrinolysis, and increased intravascular coagulation. This review discusses the pathogenesis of coagulopathy and multiple studies related to its clinical presentations. This article also highlights an additional problem in the diagnostic and therapeutic approach to this group of patients: the fact that traditional coagulation tests and transfusional strategies may not be reliable for assessing and managing bleeding or thrombotic risks. Hence, multiple management options have been assessed for bleeding and thrombosis in liver disease.
Competing Interests: Dr. Ibrahim Sange, who is the final author of the paper, contributed to writing the abstract and serves as a mentor in writing. He was also consulted on the editing and proofreading of the manuscript. For his services, a basic fee was paid to him.
(Copyright © 2022, Islam et al.)
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فهرسة مساهمة: Keywords: antifibrinolytics; blood coagulation factors; cirrhosis; deep vein thrombosis (dvt); direct acting oral anticoagulant; gastrointestinal hemorrhage; hemeostatic system; portal vein thrombosis; thrombocytopenia; venous thromboembolism (vte)
تواريخ الأحداث: Date Created: 20220506 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9063731
DOI: 10.7759/cureus.23785
PMID: 35518552
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.23785