دورية أكاديمية
The mitoXplorer 2.0 update: integrating and interpreting mitochondrial expression dynamics within a cellular context.
| العنوان: | The mitoXplorer 2.0 update: integrating and interpreting mitochondrial expression dynamics within a cellular context. |
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| المؤلفون: | Marchiano F; Aix-Marseille University, CNRS, IBDM UMR 7288, 13009 Marseille, France., Haering M; Aix-Marseille University, CNRS, IBDM UMR 7288, 13009 Marseille, France., Habermann BH; Aix-Marseille University, CNRS, IBDM UMR 7288, 13009 Marseille, France. |
| المصدر: | Nucleic acids research [Nucleic Acids Res] 2022 Jul 05; Vol. 50 (W1), pp. W490-W499. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd. |
| مواضيع طبية MeSH: | Mitochondria*/genetics , Mitochondria*/metabolism , Eukaryotic Cells*/metabolism, Gene Expression Regulation ; Signal Transduction |
| مستخلص: | Mitochondria are subcellular organelles present in almost all eukaryotic cells, which play a central role in cellular metabolism. Different tissues, health and age conditions are characterized by a difference in mitochondrial structure and composition. The visual data mining platform mitoXplorer 1.0 was developed to explore the expression dynamics of genes associated with mitochondrial functions that could help explain these differences. It, however, lacked functions aimed at integrating mitochondria in the cellular context and thus identifying regulators that help mitochondria adapt to cellular needs. To fill this gap, we upgraded the mitoXplorer platform to version 2.0 (mitoXplorer 2.0). In this upgrade, we implemented two novel integrative functions, network analysis and transcription factor enrichment, to specifically help identify signalling or transcriptional regulators of mitochondrial processes. In addition, we implemented several other novel functions to allow the platform to go beyond simple data visualization, such as an enrichment function for mitochondrial processes, a function to explore time-series data, the possibility to compare datasets across species and an IDconverter to help facilitate data upload. We demonstrate the usefulness of these functions in three specific use cases. mitoXplorer 2.0 is freely available without login at http://mitoxplorer2.ibdm.univ-mrs.fr. (© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
| تواريخ الأحداث: | Date Created: 20220507 Date Completed: 20230405 Latest Revision: 20230412 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9252804 |
| DOI: | 10.1093/nar/gkac306 |
| PMID: | 35524562 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1362-4962 |
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| DOI: | 10.1093/nar/gkac306 |