دورية أكاديمية
أعرض في EDS

Selenium nanoparticles enhance the efficacy of homologous vaccine against the highly pathogenic avian influenza H5N1 virus in chickens.

التفاصيل البيبلوغرافية
العنوان: Selenium nanoparticles enhance the efficacy of homologous vaccine against the highly pathogenic avian influenza H5N1 virus in chickens.
المؤلفون: Yehia N; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Dokki, Giza 12618, Egypt., AbdelSabour MA; Poultry Viral Vaccines Production and Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center (ARC), Egypt., Erfan AM; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Dokki, Giza 12618, Egypt., Mohammed Ali Z; Poultry Viral Vaccines Production and Research Department, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center (ARC), Egypt., Soliman RA; Researcher in Department of Evaluation of Inactivated Viral Poultry Vaccines, Central Laboratory for Evaluation of Veterinary Biologics, Agriculture Research Center (ARC), Egypt., Samy A; Reference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Dokki, Giza 12618, Egypt., Mohamed Soliman M; Clinical Laboratory Sciences Department, Turabah University College, Taif University, P.O. Box 11099, Taif 21944 Saudi Arabia., Abd El-Hack ME; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., El-Saadony MT; Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt., Ahmed KA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
المصدر: Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Apr; Vol. 29 (4), pp. 2095-2111. Date of Electronic Publication: 2021 Nov 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Biological Society Country of Publication: Saudi Arabia NLM ID: 101543796 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-562X (Print) Linking ISSN: 22137106 NLM ISO Abbreviation: Saudi J Biol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Riyadh : Saudi Biological Society : King Saud University, [2009]-
مستخلص: A proper vaccination against avian influenza viruses in chicken can significantly reduce the risk of human infection. Egypt has the highest number of recorded humans highly pathogenic avian influenza (HPAI)-H5N1 infections worldwide despite the widespread use of homologous vaccines in poultry. Enhancing H5N1 vaccine efficacy is ultimately required to better control HPAI-H5N1. The aim of this study is to boost chicken immunity by combined with inactivated HPAI-H5N1 with selenium nanoparticles (SeNPs). The chickens groups 1-3 were fed diets supplemented with SeNPs concentrations (0.25, 0.5, and 1 mg/kg) for 3 weeks and then vaccinated (inactivated HPAI-H5N1). while groups 4,5 and 6 were fed with SeNPs free diets and administered with 0.5 ml of the vaccine combined with 0.02, 0.06, and 0.1 mg/dose of SeNPs and then all groups were challenged with homologous virus 3 weeks post-vaccination (WPV). Group 7, 8 were used as control positive and negative respectively. At 4, 5, and 6 WPV, antibody titer was considerably higher in the group fed a meal supplemented with 1 mg SeNPs/kg. In contrast, both methods of SeNPs supplementation significantly increased the Interleukin 2 (IL2), Interleukin 6 (IL6), and Interferon γ (IFNγ) expressions in the blood cells in a dose-dependent manner, with a higher expression observed in the group that was vaccinated with 0.1 mg/dose. After the challenge, all groups that received SeNPs via diet or vaccines dose showed significant reduction in viral shedding and milder inflammation in lung, trachea, spleen, and liver in addition to higher expression of IL2, IL6, and IFNγ, with the highest expression observed in the group that was vaccinated with 0.1 mg/dose compared the plain vaccinated group. The groups of 1 mg SeNPs/kg and combined vaccinated with 0.1 mg/dose showed the best vaccine efficacy. However, the group vaccinated with 0.1 mg/dose showed the earliest reduction in viral shedding. Overall, SeNPs supplementation in the diet and the administration of the vaccine formula with SeNPs could enhance vaccine efficacy and provide better protection against HPAI-H5N1 in chickens by enhancing cellular immunity and reducing inflammation. We recommend using SeNPs as a vaccine combination or feeding with diet to increase the immunity and vaccine efficacy against H5N1.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 The Author(s).)
References: Evid Based Complement Alternat Med. 2008 Mar;5(1):3-15. (PMID: 18317543)
J Hematol Oncol. 2009 Jun 10;2:25. (PMID: 19515245)
J Environ Sci (China). 2021 Aug;106:1-14. (PMID: 34210425)
Emerg Infect Dis. 2016 Mar;22(3):379-88. (PMID: 26886164)
Emerg Infect Dis. 2020 Sep;26(9):2129-2136. (PMID: 32818403)
Front Vet Sci. 2020 Sep 04;7:578. (PMID: 33102545)
Saudi J Biol Sci. 2021 Aug;28(8):4461-4471. (PMID: 34354431)
J Virol. 2020 Nov 23;94(24):. (PMID: 32999029)
Animals (Basel). 2021 Oct 21;11(11):. (PMID: 34827760)
Poult Sci. 2012 Oct;91(10):2532-9. (PMID: 22991539)
Vet Immunol Immunopathol. 2020 Sep;227:110089. (PMID: 32615272)
Food Funct. 2020 Jul 1;11(7):6467-6475. (PMID: 32618989)
Saudi J Biol Sci. 2022 Feb;29(2):920-932. (PMID: 35197760)
Avian Dis. 2008 Jun;52(2):269-77. (PMID: 18646456)
Poult Sci. 2021 Aug;100(8):101266. (PMID: 34225203)
Sci Rep. 2016 Jun 03;6:27211. (PMID: 27256976)
Vaccine. 2011 Jul 26;29(33):5567-73. (PMID: 21244859)
J Virol Methods. 2004 Aug;119(2):151-8. (PMID: 15158597)
Saudi J Biol Sci. 2022 Feb;29(2):1197-1209. (PMID: 35197787)
J Clin Microbiol. 2009 Mar;47(3):674-9. (PMID: 19109473)
Epidemiol Infect. 2011 May;139(5):647-57. (PMID: 21281550)
Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101594. (PMID: 33271478)
Animals (Basel). 2021 Jun 24;11(7):. (PMID: 34202621)
Nanomaterials (Basel). 2020 Mar 23;10(3):. (PMID: 32210153)
Vaccine. 2017 Oct 27;35(45):6195-6201. (PMID: 28958814)
Immunopharmacol Immunotoxicol. 1994 May;16(2):203-23. (PMID: 8077607)
J Nutr. 2008 Mar;138(3):439-42. (PMID: 18287346)
ACS Omega. 2020 Nov 16;5(47):30633-30642. (PMID: 33283112)
J Immunol. 2005 Sep 15;175(6):3463-8. (PMID: 16148087)
Mol Nutr Food Res. 2008 Nov;52(11):1273-80. (PMID: 18384097)
Vet Microbiol. 2016 Feb 1;183:103-9. (PMID: 26790942)
Free Radic Biol Med. 2007 May 15;42(10):1524-33. (PMID: 17448899)
Front Pharmacol. 2021 Jul 30;12:682284. (PMID: 34393776)
J Immunol. 2003 Aug 15;171(4):1809-15. (PMID: 12902481)
Biol Trace Elem Res. 2012 Sep;148(3):322-30. (PMID: 22426748)
Poult Sci. 2021 Jun;100(6):101172. (PMID: 33951594)
Poult Sci. 2020 Nov;99(11):5430-5439. (PMID: 33142460)
J Virol. 2009 Aug;83(15):7475-86. (PMID: 19457987)
Mol Biol Evol. 2013 Dec;30(12):2725-9. (PMID: 24132122)
Animals (Basel). 2020 Mar 04;10(3):. (PMID: 32143370)
Asian-Australas J Anim Sci. 2013 Feb;26(2):247-52. (PMID: 25049783)
Virus Evol. 2020 Nov 21;6(2):veaa079. (PMID: 33324491)
Arch Virol. 2016 Oct;161(10):2797-806. (PMID: 27449156)
Nutrition. 2017 Jan;33:83-90. (PMID: 27356860)
Saudi J Biol Sci. 2021 Aug;28(8):4592-4604. (PMID: 34354445)
Int J Nanomedicine. 2017 Aug 09;12:5733-5743. (PMID: 28848350)
Infect Genet Evol. 2016 Jun;40:80-90. (PMID: 26917362)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Biol Trace Elem Res. 2015 Jun;165(2):183-93. (PMID: 25721721)
J Mol Genet Med. 2009 Dec 09;3(2):198-204. (PMID: 20076791)
Saudi J Biol Sci. 2021 Oct;28(10):5674-5683. (PMID: 34588879)
Lancet. 2004 Apr 3;363(9415):1099-103. (PMID: 15064027)
Euro Surveill. 2015 Apr 02;20(13):2-8. (PMID: 25860390)
Emerg Microbes Infect. 2019;8(1):1370-1382. (PMID: 31526249)
J Virol Methods. 2012 Dec;186(1-2):119-25. (PMID: 22925717)
PLoS Pathog. 2008 Feb 29;4(2):e1000006. (PMID: 18389078)
Toxicol Sci. 2008 Jan;101(1):22-31. (PMID: 17728283)
Comp Immunol Microbiol Infect Dis. 2019 Aug;65:165-175. (PMID: 31300109)
Poult Sci. 2009 Apr;88(4):860-6. (PMID: 19276436)
فهرسة مساهمة: Keywords: Avian influenza; HPAI (H5N1); Humoral immunity; Nanoselenium; Vaccine
تواريخ الأحداث: Date Created: 20220509 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9072940
DOI: 10.1016/j.sjbs.2021.11.051
PMID: 35531142
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-562X
DOI:10.1016/j.sjbs.2021.11.051