دورية أكاديمية
أعرض في EDS

A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity.

التفاصيل البيبلوغرافية
العنوان: A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity.
المؤلفون: de Medeiros WMTQ; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com., de Medeiros MJC; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com., Carvalho EM; Laboratório de Bioinorgânica, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará (UFC) Cx. Postal 6021 Fortaleza 60440-900 Brazil., de Lima JA; Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59072-970 Brazil., da S Oliveira V; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com., de B Pontes ACF; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com., da Silva FON; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com., Ellena JA; Instituto de Física de São Carlos, Universidade de São Paulo 13560-970 São Carlos SP Brazil., de O Rocha HA; Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59072-970 Brazil., de Sousa EHS; Laboratório de Bioinorgânica, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará (UFC) Cx. Postal 6021 Fortaleza 60440-900 Brazil., de L Pontes D; Laboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN) Natal 59078-970 Brazil pontesdl@yahoo.com.
المصدر: RSC advances [RSC Adv] 2018 May 10; Vol. 8 (30), pp. 16873-16886. Date of Electronic Publication: 2018 May 10 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص: Vanillin (vanH) is the major component of vanilla and one of the most widely used flavoring agents. In this work the complex [Cu(phen)(van) 2 ] was prepared and characterized by structural (X-ray), spectroscopic (IR, UV-Vis, EPR) and electrochemical techniques. This compound showed an octahedral geometry with an unusual arrangement of the vanillin ligands, where the methoxy groups of the vanillinate ions are coordinated opposite to each other. The compound promoted DNA cleavage in the presence of glutathione (GSH) and H 2 O 2 . At 40 μmol L -1 of complex with GSH (10 mmol L -1 ), there is a complete cleavage of DNA to nicked form II, while only at 10 μmol L -1 of this complex with H 2 O 2 (1 mmol L -1 ) an extensive cleavage leading to form III took place. Additionally, we have evidences of superoxide generation upon reaction with GSH. Therefore, DNA fragmentation occurs likely through an oxidative pathway. MTT assays indicated that the complex is highly cytotoxic against three distinct cell lines: B16-F10 (IC 50 = 3.39 ± 0.61 μmol L -1 ), HUH-7 (IC 50 = 4.22 ± 0.31 μmol L -1 ) and 786-0 (IC 50 = 10.38 ± 0.91 μmol L -1 ). Flow cytometry studies conducted with 786-0 cell line indicated cell death might occur by apoptosis. Cell cycle progression evaluated at 5 and 10 μmol L -1 resulted in a clear increase of 786-0 cells at G1 phase and depletion of G2/M, while higher doses showed an expressive increase of sub-G1 phase. Altogether, these results pointed out to a promising biological activity and potential as an anti-cancer agent.
Competing Interests: There are no conflicts to declare
(This journal is © The Royal Society of Chemistry.)
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تواريخ الأحداث: Date Created: 20220511 Latest Revision: 20240827
رمز التحديث: 20240827
مُعرف محوري في PubMed: PMC9080323
DOI: 10.1039/c8ra03626h
PMID: 35540529
قاعدة البيانات: MEDLINE
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