دورية أكاديمية
أعرض في EDS

Prediabetes and insulin resistance in a population of patients with heart failure and reduced or preserved ejection fraction but without diabetes, overweight or hypertension.

التفاصيل البيبلوغرافية
العنوان: Prediabetes and insulin resistance in a population of patients with heart failure and reduced or preserved ejection fraction but without diabetes, overweight or hypertension.
المؤلفون: Son TK; Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Toan NH; Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Thang N; Science - Technology & External Relations Office, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Le Trong Tuong H; Cardiology Department, Can Tho Central General Hospital, Can Tho, Vietnam., Tien HA; Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam., Thuy NH; Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam., Van Minh H; Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam., Valensi P; Unit of Endocrinology-Diabetology-Nutrition. Jean Verdier hospital, APHP, Sorbonne Paris Nord University, CINFO, CRNH-IdF, Bondy, France. paul.valensi@aphp.fr.
المصدر: Cardiovascular diabetology [Cardiovasc Diabetol] 2022 May 14; Vol. 21 (1), pp. 75. Date of Electronic Publication: 2022 May 14.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Diabetes Mellitus*/diagnosis , Diabetes Mellitus*/epidemiology , Heart Failure*/diagnosis , Heart Failure*/epidemiology , Hypertension*/diagnosis , Hypertension*/epidemiology , Insulin Resistance* , Prediabetic State*/diagnosis , Prediabetic State*/epidemiology, Aged ; Cross-Sectional Studies ; Glucose ; Humans ; Insulin ; Lipids ; Overweight/diagnosis ; Overweight/epidemiology ; Prognosis ; Prospective Studies ; Stroke Volume/physiology
مستخلص: Background: The relationships between glucose abnormalities, insulin resistance (IR) and heart failure (HF) are unclear, especially regarding to the HF type, i.e., HF with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Overweight, diabetes and hypertension are potential contributors to IR in persons with HF. This study aimed to evaluate the prevalence of prediabetes and IR in a population of Vietnamese patients with HFrEF or HFpEF but no overweight, diabetes or hypertension, in comparison with healthy controls, and the relation between prediabetes or IR and HF severity.
Methods: We conducted a prospective cross-sectional observational study in 190 non-overweight normotensive HF patients (114 with HFrEF and 76 with HFpEF, 92.6% were ischemic HF, mean age was 70.1 years, mean BMI 19.7 kg/m 2 ) without diabetes (neither known diabetes nor newly diagnosed by OGTT) and 95 healthy individuals (controls). Prediabetes was defined using 2006 WHO criteria. Glucose and insulin levels were measured fasting and 2 h after glucose challenge. IR was assessed using HOMA-IR and several other indexes.
Results: Compared to controls, HF patients had a higher prevalence of prediabetes (63.2% vs 22.1%) and IR (according to HOMA-IR, 55.3% vs 26.3%), higher HOMA-IR, insulin/glucose ratio after glucose and FIRI, and lower ISIT0 and ISIT120 (< 0.0001 for all comparisons), with no difference for body weight, waist circumference, blood pressure and lipid parameters. Prediabetes was more prevalent (69.3% vs 53.9%, p = 0.03) and HOMA-IR was higher (p < 0.0001) in patients with HFrEF than with HFpEF. Among both HFrEF and HFpEF patients, those with prediabetes or IR had a more severe HF (higher NYHA functional class and NT-proBNP levels, lower ejection fraction; p = 0.04-< 0.0001) than their normoglycemic or non-insulinresistant counterparts, with no difference for blood pressure and lipid parameters.
Conclusion: In non-diabetic non-overweight normotensive patients with HF, the prevalence of prediabetes is higher with some trend to more severe IR in those with HFrEF than in those with HFpEF. Both prediabetes and IR are associated with a more severe HF. The present data support HF as a culprit for IR. Intervention strategies should be proposed to HF patients with prediabetes aiming to reduce the risk of incident diabetes. Studies should be designed to test whether such strategies may translate into an improvement of further HF-related outcomes.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Heart failure; Heart failure with preserved ejection fraction; Heart failure with reduced ejection fraction; Insulin resistance; Oral glucose tolerance test; Prediabetes
المشرفين على المادة: 0 (Insulin)
0 (Lipids)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20220515 Date Completed: 20220519 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9107647
DOI: 10.1186/s12933-022-01509-5
PMID: 35568879
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2840
DOI:10.1186/s12933-022-01509-5