دورية أكاديمية
أعرض في EDS

Clinical and Cardiovascular Magnetic Resonance Predictors of Early and Long-Term Clinical Outcome in Acute Myocarditis.

التفاصيل البيبلوغرافية
العنوان: Clinical and Cardiovascular Magnetic Resonance Predictors of Early and Long-Term Clinical Outcome in Acute Myocarditis.
المؤلفون: Bohbot Y; Department of Cardiology, Amiens University Hospital, Amiens, France.; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Garot J; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Hovasse T; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Unterseeh T; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Di Lena C; Department of Cardiology, Amiens University Hospital, Amiens, France., Boukefoussa W; Department of Cardiology, Amiens University Hospital, Amiens, France., Tawa C; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Renard C; Department of Radiology, Amiens University Hospital, Amiens, France., Limouzineau I; Department of Cardiology, Amiens University Hospital, Amiens, France., Duhamel S; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Garot P; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France., Tribouilloy C; Department of Cardiology, Amiens University Hospital, Amiens, France., Sanguineti F; Institut Cardiovasculaire Paris Sud (ICPS), CMR Department, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France.
المصدر: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Apr 29; Vol. 9, pp. 886607. Date of Electronic Publication: 2022 Apr 29 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Introduction: The natural history of acute myocarditis (AM) remains partially unknown and predictors of outcome are debated. We sought to assess the impact of various cardiac magnetic resonance (CMR) parameters on early and long-term prognosis in a population of patients with AM.
Materials and Methods: In a two-center longitudinal study, we included consecutive patients with diagnosis of AM based on CMR and without hemodynamic compromise. The primary endpoint was the occurrence of an event in the acute phase (≤15 days). Secondary endpoints were the occurrence of major adverse cardiac events (MACE) and recurrence of AM during follow-up.
Results: Three hundred and eighty-eight patients were included [mean age 38.5 years, 77.3% male, mean ejection fraction (EF):56%] of which 82% (317) presented with chest pain. CMR was performed 4 ± 2 days after index presentation. Overall, 38 patients (9.8%) had an event at the acute phase, 41 (10.6%) presented at least one MACE during follow-up (median 7.5 years, 6.6-8.9) and 30 (7.7%) experienced a recurrence of AM. By multivariate analysis, the independent predictors of initial complications were absence of chest pain (OR [95%CI] = 0.35 [0.15-0.82]), presence of syncope/pre-syncope (OR [95%CI] = 3.56 [1.26-10.02]), lower EF (OR [95%CI] = 0.94 [0.91-0.98] per%), myocardial extent of late gadolinium enhancement (LGE) (OR [95%CI] = 1.05 [1.002-1.100] per%) and absence of edema (OR [95%CI] = 0.44 [0.19-0.97]). Only age (HR [95%CI] = 1.021 [1.001-1.041] per year) and an initial alteration of EF (HR [95%CI] = 0.94 [0.91-0.97] per%) were associated with MACE during follow-up. Factors independently associated with AM recurrence were myocarditis prior to the index episodes (HR [95%CI] = 5.74 [1.72-19.22]) and viral syndrome at the index episode (HR [95%CI] = 4.21 [1.91-9.28]).
Conclusion: In routine consecutive hemodynamically stable patients with diagnosis of AM based on CMR, absence of edema, reduced EF, and extent of LGE were associated with early adverse outcome. Only age and EF were associated with long-term events.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Bohbot, Garot, Hovasse, Unterseeh, Di Lena, Boukefoussa, Tawa, Renard, Limouzineau, Duhamel, Garot, Tribouilloy and Sanguineti.)
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فهرسة مساهمة: Keywords: cardiovascular magnetic resonance; late gadolinium enhancement; left ventricular ejection fraction; myocarditis; outcome
تواريخ الأحداث: Date Created: 20220516 Latest Revision: 20220519
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9098834
DOI: 10.3389/fcvm.2022.886607
PMID: 35571177
قاعدة البيانات: MEDLINE
الوصف
تدمد:2297-055X
DOI:10.3389/fcvm.2022.886607