دورية أكاديمية
Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery.
| العنوان: | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery. |
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| المؤلفون: | Zhang X; Department of Anesthesiology, Capital Institute of Pediatrics Affiliated Children's Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China., Chang L; Department of Respiratory Medicine, Capital Institute of Pediatrics Affiliated Children's Hospital, Beijing, China., Pan SD; Department of Anesthesiology, Capital Institute of Pediatrics Affiliated Children's Hospital, Beijing, China., Yan FX; Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China. |
| المصدر: | Frontiers in pediatrics [Front Pediatr] 2022 Apr 27; Vol. 10, pp. 871809. Date of Electronic Publication: 2022 Apr 27 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA, [2013]- |
| مستخلص: | Background: Previous studies have reported that children who were admitted to the ICU experienced a significant decrease in sleep quality compared to home. We investigated the effects of dexmedetomidine as an adjunct to sufentanil on the sleep in children admitted to the ICU on the first night after major surgery. Methods: This is a prospective study From January to February 2022. Clinical trial number: ChiCTR2200055768, http://www.chictr.org.cn. Fifty-four children aged 1-10 years old children undergoing major laparoscopic surgery were recruited and randomly assigned to either the DEX group, in which intravenous dexmedetomidine (0.3 ug/kg/h) and sufentanil (0.04 ug/kg/h) were continuously infused intravenously for post-operative analgesia; or the SUF group, in which only sufentanil (0.04 ug/kg/h) was continuously infused. Patients were monitored with polysomnography (PSG) on the first night after surgery for 12 h. PSG, sleep architecture, physiologic variables and any types of side effects related to anesthesia and analgesia were recorded. The differences between the two groups were assessed using the chi-square and Wilcoxon rank-sum tests. Results: Fifty-four children completed data collection, of which thirty-four were 1-6 years old and twenty were aged >6 years. Compared to the SUF group, subjects in the DEX group aged 1-6 years displayed increased stage 2 sleep duration ( P = 0.02) and light sleep duration ( P = 0.02). Subjects aged >6 years in the DEX group also displayed increased stage 2 sleep duration ( P = 0.035) and light sleep duration ( P = 0.018), but decreased REM sleep percentage ( P = 0). Additionally, the heart rate and blood pressure results differed between age groups, with the heart rates of subjects aged >6 years in DEX group decreasing at most time points compared to SUF group ( P < 0.05). Conclusion: Dexmedetomidine prolonged N2 sleep and light sleep duration in the pediatric ICU after surgery but had different effects on the heart rate and blood pressure of subjects in different age groups. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Zhang, Chang, Pan and Yan.) |
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| فهرسة مساهمة: | Keywords: children; dexmedetomidine; post-operative analgesia; sleep; sufentanil |
| تواريخ الأحداث: | Date Created: 20220516 Latest Revision: 20220519 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9091560 |
| DOI: | 10.3389/fped.2022.871809 |
| PMID: | 35573948 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-2360 |
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| DOI: | 10.3389/fped.2022.871809 |