دورية أكاديمية
أعرض في EDS

First application of the BIANCA biophysical model to carbon-ion patient cases.

التفاصيل البيبلوغرافية
العنوان: First application of the BIANCA biophysical model to carbon-ion patient cases.
المؤلفون: Kozłowska WS; Medical University of Vienna, Vienna, Austria., Carante MP; University of Pavia, Physics Department, Pavia, Italy.; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, Pavia, Italy., Aricò G; Optimization of Medical Accelerators, Warrington, United Kingdom., Embriaco A; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, Pavia, Italy.; ENEA-Casaccia, Roma, Italy., Ferrari A; University Hospital Heidelberg, Heidelberg, Germany.; Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Magro G; CNAO (Centro Nazionale di Adroterapia Oncologica), Pavia, Italy., Mairani A; CNAO (Centro Nazionale di Adroterapia Oncologica), Pavia, Italy.; HIT (Heidelberg Ion-beam Therapy Center), Heidelberg, Germany., Ramos R; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, Pavia, Italy., Sala P; INFN (Italian National Institute for Nuclear Physics), Sezione di Milano, Milano, Italy., Georg D; Medical University of Vienna, Vienna, Austria., Ballarini F; University of Pavia, Physics Department, Pavia, Italy.; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, Pavia, Italy.
المصدر: Physics in medicine and biology [Phys Med Biol] 2022 May 27; Vol. 67 (11). Date of Electronic Publication: 2022 May 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bristol : IOP Publishing
مواضيع طبية MeSH: Chordoma* , Heavy Ion Radiotherapy*/methods, Carbon/therapeutic use ; Chromosome Aberrations ; Humans ; Ions ; Male ; Radiotherapy Planning, Computer-Assisted/methods ; Relative Biological Effectiveness
مستخلص: Objective. The main objective of this work consists of applying, for the first time, the BIANCA (BIophysical ANalysis of Cell death and chromosome Aberrations) biophysical model to the RBE calculation for C-ion cancer patients, and comparing the outcomes with those obtained by the LEM I model, which is applied in clinics. Indeed, the continuous development of heavy-ion cancer therapy requires modelling of biological effects of ion beams on tumours and normal tissues. The relative biological effectiveness (RBE) of heavy ions is higher than that of protons, with a significant variation along the beam path. Therefore, it requires a precise modelling, especially for the pencil-beam scanning technique. Currently, two radiobiological models, LEM I and MKM, are in use for heavy ions in scanned pencil-beam facilities. Approach. Utilizing an interface with the FLUKA Particle Therapy Tool, BIANCA was applied to re-calculate the RBE-weighted dose distribution for carbon-ion treatment of three patients (chordoma, head-and-neck and prostate) previously irradiated at CNAO, where radiobiological optimization was based on LEM I. The predictions obtained by BIANCA were based either on chordoma cell survival ( RBE surv ), or on dicentric aberrations in peripheral blood lymphocytes ( RBE ab ), which are indicators of late normal tissue damage, including secondary tumours. The simulation outcomes were then compared with those provided by LEM I. Main results. While in the target and in the entrance channel BIANCA predictions were lower than those obtained by LEM I, the two models provided very similar results in the considered OAR. The observed differences between RBE surv and RBE ab (which were also dependent on fractional dose and LET) suggest that in normal tissues the information on cell survival should be integrated by information more closely related to the induction of late damage, such as chromosome aberrations. Significance. This work showed that BIANCA is suitable for treatment plan optimization in ion-beam therapy, especially considering that it can predict both cell survival and chromosome aberrations and has previously shown good agreement with carbon-ion experimental data.
(© 2022 Institute of Physics and Engineering in Medicine.)
فهرسة مساهمة: Keywords: BIANCA; RBE; carbon ion; heavy ion; particle therapy
المشرفين على المادة: 0 (Ions)
7440-44-0 (Carbon)
تواريخ الأحداث: Date Created: 20220516 Date Completed: 20220531 Latest Revision: 20220607
رمز التحديث: 20240829
DOI: 10.1088/1361-6560/ac702b
PMID: 35576922
قاعدة البيانات: MEDLINE
الوصف
تدمد:1361-6560
DOI:10.1088/1361-6560/ac702b