دورية أكاديمية
أعرض في EDS

Description of Methicillin-Susceptible Staphylococcus aureus Clonal Complex 30 Related to the Pandemic Phage Type 80/81 Isolated from Patients in Three Tertiary Hospitals in Jos, North Central Nigeria.

التفاصيل البيبلوغرافية
العنوان: Description of Methicillin-Susceptible Staphylococcus aureus Clonal Complex 30 Related to the Pandemic Phage Type 80/81 Isolated from Patients in Three Tertiary Hospitals in Jos, North Central Nigeria.
المؤلفون: Essien UC; Faculty of Health Sciences and Technology, University of Jos, Jos, Nigeria.; Department of Medical Laboratory Science, Nnewi Campus, Nnamdi Azikiwe University, Awka, Nigeria., Boswihi SS; Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait., Agbakoba NR; Department of Medical Laboratory Science, Nnewi Campus, Nnamdi Azikiwe University, Awka, Nigeria., Udo EE; Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
المصدر: Medical principles and practice : international journal of the Kuwait University, Health Science Centre [Med Princ Pract] 2022; Vol. 31 (3), pp. 269-275. Date of Electronic Publication: 2022 May 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 8901334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0151 (Electronic) Linking ISSN: 10117571 NLM ISO Abbreviation: Med Princ Pract Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel (Schweiz) ; New York : Karger, [1988-
مواضيع طبية MeSH: Bacteriophages*/genetics , Methicillin-Resistant Staphylococcus aureus*/genetics , Staphylococcal Infections*/epidemiology, Anti-Bacterial Agents/pharmacology ; Humans ; Methicillin ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Nigeria/epidemiology ; Pandemics ; Staphylococcus aureus/genetics ; Tertiary Care Centers
مستخلص: Objective: The prevalence of phage 80/81 Staphylococcus aureus strains, the pandemic strains that were dominant in the 1950s, had declined in the 1960s and 1970s. However, these strains have reemerged in some countries in recent years. This study investigated the antibacterial resistance, virulence, and the genetic backgrounds of CC30-MSSA isolates obtained from patients in three tertiary hospitals.
Materials and Methods: Twenty-two CC30-MSSA isolates cultured from different clinical samples were investigated using antibiotic sensitivity testing, spa typing, multilocus sequence typing, and DNA microarray analysis.
Results: All 22 isolates were susceptible to vancomycin (MIC ≤2 μg/mL), teicoplanin (MIC ≤2 μg/mL), and cefoxitin but were resistant to penicillin G (n = 22; 100.0%), tetracycline (n = 12; 54.5%), ciprofloxacin (n = 15; 68.2%), cadmium acetate (n = 22; 100%), mercuric chloride (n = 13; 59.1%), and ethidium bromide (n = 3; 13.6%). The isolates belonged to sequence type, ST30, and five spa types: t012 (n = 12; 54.5%), t019 (n = 5; 22.7%), t017 (n = 2; 9.1%), t037 (n = 2; 9.1%), and t318 (n = 1; 4.5%). All 22 isolates were positive for agrIII, cap8, clfA, clfB, icaA, icaC, icaD, cna, and staphylococcal enterotoxin gene clusters (seg, sei, sem, sen, seo, seu). Eight isolates carried lukS-PV and lukF-PV that code for Panton-Valentine leukocidin.
Conclusion: The current CC30-MSSA isolates share phenotypic and genotypic characteristics with the pandemic phage 80/81 isolates that were common in the 1950s and 1960s. Continued surveillance is recommended to keep abreast of the changing epidemiology of S. aureus causing healthcare and community-associated infections.
(© 2022 The Author(s). Published by S. Karger AG, Basel.)
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فهرسة مساهمة: Keywords: DNA microarray; Methicillin-sensitive Staphylococcus aureus; Panton-valentine leukocidin; Sequence type 30; spa typing
المشرفين على المادة: 0 (Anti-Bacterial Agents)
Q91FH1328A (Methicillin)
تواريخ الأحداث: Date Created: 20220517 Date Completed: 20220707 Latest Revision: 20240831
رمز التحديث: 20240831
مُعرف محوري في PubMed: PMC9275013
DOI: 10.1159/000524755
PMID: 35580557
قاعدة البيانات: MEDLINE
الوصف
تدمد:1423-0151
DOI:10.1159/000524755