دورية أكاديمية
Development and an initial validation of the Responses to Illness Severity Quantification (RISQ) score for severely malnourished children.
| العنوان: | Development and an initial validation of the Responses to Illness Severity Quantification (RISQ) score for severely malnourished children. |
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| المؤلفون: | Dale NM; Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada.; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Canada.; Center for Safety Research, Toronto, Ontario, Canada.; Tampere Center for Child, Adolescent, and Maternal Health Research: Global Health Group, University of Tampere, Tampere, Finland., Ashir GM; Department of Pediatrics, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria., Maryah LB; Department of Pediatrics, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria., Shepherd S; Alliance for International Medical Action, Dakar, Senegal., Tomlinson G; Department of Medicine, University Health Network, Toronto, Canada., Briend A; Tampere Center for Child, Adolescent, and Maternal Health Research: Global Health Group, University of Tampere, Tampere, Finland.; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark., Zlotkin S; Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada.; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Canada.; Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada., Parshuram C; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Canada.; Center for Safety Research, Toronto, Ontario, Canada.; Department of Critical Care Medicine, Hospital for Sick Children, Toronto, Canada. |
| المصدر: | Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2022 Sep; Vol. 111 (9), pp. 1752-1763. Date of Electronic Publication: 2022 Jun 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Norway NLM ID: 9205968 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2227 (Electronic) Linking ISSN: 08035253 NLM ISO Abbreviation: Acta Paediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Oslo : Wiley-Blackwell Original Publication: Oslo : Scandinavian University Press, c1992- |
| مواضيع طبية MeSH: | Child Nutrition Disorders*/diagnosis , Severe Acute Malnutrition*/diagnosis, Child ; Humans ; Infant ; Nigeria ; Patient Acuity ; Prospective Studies ; Severity of Illness Index |
| مستخلص: | Aim: To develop and perform an initial validation of a score to measure the severity of illness in hospitalised children with severe acute malnutrition (SAM). Methods: A prospective study enrolled SAM children aged 6-59 months hospitalised in Borno State, Nigeria. Candidate items associated with inpatient mortality were combined and evaluated as candidate scores. Clinical and statistical methods were used to identify a preferred score. Results: The 513 children enrolled had a mean age of 15.6 months of whom 48 (9%) died. Seven of the 10 evaluated items were significantly associated with mortality. Five different candidate scores were tested. The final score, Responses to Illness Severity Quantification (RISQ), included seven items: heart rate, respiratory rate, respiratory effort, oxygen saturation, oxygen delivery, temperature and level of consciousness. The mean RISQ score on admission was 2.6 in hospital survivors and 7.3 for children dying <48 h. RISQ scores <24 h before death had an area under the receiver operating characteristic curve (AUROC) of 0.93. The RISQ score performed similarly across differing clinical conditions with AUROCs 0.77-0.98 for all conditions except oedema. Conclusion: The RISQ score can identify high-risk malnourished children at and during hospital admission. Clinical application may help prioritise care and potentially improve survival. (© 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.) |
| التعليقات: | Comment in: Acta Paediatr. 2022 Sep;111(9):1658-1659. (PMID: 35822532) |
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| معلومات مُعتمدة: | Mining4Life Chair in Mineral Nutrition through the SickKids Foundation; SickKids Centre for Global Child Health Catalyst Grant; The Alliance for International Medical Action |
| فهرسة مساهمة: | Keywords: malnutrition; mortality; score; severity of illness |
| تواريخ الأحداث: | Date Created: 20220518 Date Completed: 20220809 Latest Revision: 20221208 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9545493 |
| DOI: | 10.1111/apa.16410 |
| PMID: | 35582782 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1651-2227 |
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| DOI: | 10.1111/apa.16410 |