دورية أكاديمية
Temporal changes and clinical significance of peridevice leak following left atrial appendage occlusion with Amplatzer devices.
| العنوان: | Temporal changes and clinical significance of peridevice leak following left atrial appendage occlusion with Amplatzer devices. |
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| المؤلفون: | Korsholm K; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Jensen JM; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Nørgaard BL; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Nielsen-Kudsk JE; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. |
| المصدر: | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2022 Jun; Vol. 99 (7), pp. 2071-2079. Date of Electronic Publication: 2022 May 18. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 100884139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-726X (Electronic) Linking ISSN: 15221946 NLM ISO Abbreviation: Catheter Cardiovasc Interv Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Wiley-Liss, c1999- |
| مواضيع طبية MeSH: | Atrial Appendage*/diagnostic imaging , Atrial Fibrillation*/complications , Atrial Fibrillation*/diagnosis , Atrial Fibrillation*/therapy , Septal Occluder Device*/adverse effects , Stroke*/etiology , Stroke*/prevention & control, Cardiac Catheterization ; Echocardiography, Transesophageal ; Humans ; Tomography ; Treatment Outcome |
| مستخلص: | Background: The natural history of peridevice leak (PDL) following left atrial appendage occlusion (LAAO) is unknown. This study sought to investigate changes of PDL from 2 until 12 months after LAAO, using cardiac computed tomography (CT), and to assess the potential association between persistent PDL and clinical outcomes METHODS: Single-center observational study of Amplatzer LAAO implants between 2010 and 2017 (n = 206). Patients with 2 and 12 months cardiac CT were included in the study (n = 153). Images were blindly analyzed. PDL was characterized by frequency and size at the device disc, lobe, and left atrial appendage contrast patency. Patients were followed for the composite outcome of ischemic stroke, transient ischemic attack, systemic embolism, or all-cause death. Median follow up from LAAO was 3.1 (2.3-4.3) years. Results: Contrast patency was present in 101 (66%) and 72 (47%) (p < 0.001) at 2 and 12 months, respectively. PDL was identified at the disc in 103 (67%) patients at 2 months versus 93 (61%) at 12 months (p = 0.08), and at the lobe in 29 (19%) at both time points. PDL area at the disc did not change significantly over time, ∆ $\unicode{x02206}$ area: -8.95 mm (95% confidence interval [CI]: -18.9; 1.01) p = 0.08. Permanent atrial fibrillation was independently associated with persistent PDL. Persistent versus no PDL was associated with a 62% worse clinical outcome, however not statistically significant, hazard ratio (HR): 1.62 (95% CI: 0.9-2.93), p = 0.11. Conclusion: Persistent PDL was frequently observed following LAAO with Amplatzer devices. The PDL frequency and size appeared unchanged between 2 and 12 months. Persistent PDL was not significantly associated with worse clinical outcomes, yet this needs further delineation in future studies. (© 2022 The Authors. Catheterization and Cardiovascular Interventions published by Wiley Periodicals LLC.) |
| التعليقات: | Comment in: Catheter Cardiovasc Interv. 2022 Jun;99(7):2080-2081. (PMID: 35674105) |
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| معلومات مُعتمدة: | NNF17OC0024868 Novo Nordisk Foundation Center for Basic Metabolic Research; NNF17OC0029510 Novo Nordisk Foundation Center for Basic Metabolic Research |
| فهرسة مساهمة: | Keywords: CLLA-closure; SHDI-structural heart disease intervention; STR-stroke; TTE/TEE; left atrial appendage |
| تواريخ الأحداث: | Date Created: 20220518 Date Completed: 20220609 Latest Revision: 20221015 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9541112 |
| DOI: | 10.1002/ccd.30178 |
| PMID: | 35582829 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1522-726X |
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| DOI: | 10.1002/ccd.30178 |