دورية أكاديمية
Breathing Exercises for Patients with Asthma in Specialist Care: A Multicenter Randomized Clinical Trial.
| العنوان: | Breathing Exercises for Patients with Asthma in Specialist Care: A Multicenter Randomized Clinical Trial. |
|---|---|
| المؤلفون: | Andreasson KH; The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Slagelse, Denmark.; Department of Respiratory Medicine, Naestved-Slagelse-Ringsted Hospitals, Naestved, Denmark.; Institute of Regional Health Research and., Skou ST; The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Naestved-Slagelse-Ringsted Hospitals, Slagelse, Denmark.; Research Unit for Musculoskeletal Function and Physiotherapy, University of Southern Denmark, Odense, Denmark., Ulrik CS; Department of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Madsen H; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark., Sidenius K; Allergy and Lung Clinic, Elsinore, Denmark., Assing KD; Department of Respiratory Medicine, Aalborg University Hospital, Aalborg, Denmark., Porsbjerg C; Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark., Bloch-Nielsen J; Department of Physiotherapy and Occupational Therapy, and Pulmonary Disease Unit, Diagnostic Center, Silkeborg Regional Hospital, Silkeborg, Denmark., Thomas M; Department of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, United Kingdom; and., Bodtger U; Department of Respiratory Medicine, Naestved-Slagelse-Ringsted Hospitals, Naestved, Denmark.; Institute of Regional Health Research and.; Department of Respiratory Medicine, Zealand University Hospital, Roskilde, Denmark. |
| المصدر: | Annals of the American Thoracic Society [Ann Am Thorac Soc] 2022 Sep; Vol. 19 (9), pp. 1498-1506. |
| نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 101600811 Publication Model: Print Cited Medium: Internet ISSN: 2325-6621 (Electronic) Linking ISSN: 23256621 NLM ISO Abbreviation: Ann Am Thorac Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : American Thoracic Society, [2013]- |
| مواضيع طبية MeSH: | Asthma*/therapy , Quality of Life*, Adult ; Breathing Exercises ; Exercise Therapy ; Humans ; Surveys and Questionnaires |
| مستخلص: | Rationale: Moderate to severe asthma is associated with impaired asthma control and quality of life (QoL) despite access to specialist care and modern pharmacotherapy. Breathing exercises (BrEX) improve QoL in incompletely controlled mild asthma, but impact in moderate to severe asthma is unknown. Objectives: To investigate the effectiveness of BrEX as adjuvant treatment on QoL in patients with uncontrolled moderate to severe asthma. Methods: Adult patients with incompletely controlled asthma attending respiratory specialist clinics were randomized to usual specialist care (UC) or UC and BrEX (UC + BrEX) with three individual physiotherapist-delivered sessions and home exercises. Primary outcome was asthma-related QoL (Mini-Asthma Quality of Life Questionnaire [Mini-AQLQ]) at 6 months on the basis of intention-to-treat analysis. Secondary outcomes: Mini-AQLQ at 12 months, lung function, 6-minute-walk test, physical activity level, Nijmegen Questionnaire, Hospital Anxiety and Depression Scale, and adverse events. Repeated-measures mixed-effects models were used to analyze data. Poisson regression models were used to analyze adverse event incidence rate ratio. Results: A total of 193 participants were allocated to UC + BrEX ( n = 94) or UC ( n = 99). UC + BrEX was superior in the primary outcome (adjusted mean change difference, 0.35; 95% confidence interval [CI], 0.07 to 0.62). Superiority in Mini-AQLQ was sustained at 12 months (0.38; 95% CI, 0.12 to 0.65). A minor improvement in Hospital Anxiety and Depression Scale depression score at 6 months favoring UC + BrEX (-0.90; 95% CI, -1.67 to -0.14) was observed. Asthma-related adverse events occurred similarly in UC + BrEX and UC participants: 14.9% versus 18.1% ( P = 0.38). Conclusions: BrEX as add-on to usual care improve asthma-related QoL in incompletely controlled asthma regardless of severity and with no evidence of harm. Clinical trial registered with www.clinicaltrials.gov (NCT03127059). |
| References: | Respir Med. 2020 Mar;163:105894. (PMID: 32056838) Thorax. 2003 Feb;58(2):110-5. (PMID: 12554890) Complement Ther Clin Pract. 2014 Nov;20(4):276-9. (PMID: 25130138) Thorax. 2007 Dec;62(12):1039-42. (PMID: 17573445) Eur Respir Rev. 2015 Jun;24(136):361-9. (PMID: 26028647) Respir Res. 2021 Jan 30;22(1):33. (PMID: 33516207) Acta Psychiatr Scand. 1983 Jun;67(6):361-70. (PMID: 6880820) J Clin Epidemiol. 2014 Jul;67(7):769-72. (PMID: 24560088) Expert Rev Pharmacoecon Outcomes Res. 2011 Apr;11(2):171-84. (PMID: 21476819) Chest. 2006 Apr;129(4):925-32. (PMID: 16608940) Lancet Respir Med. 2018 Jan;6(1):19-28. (PMID: 29248433) BMJ. 1998 Feb 28;316(7132):690-3. (PMID: 9522799) Expert Rev Respir Med. 2011 Dec;5(6):789-807. (PMID: 22082165) Appl Physiol Nutr Metab. 2011 Jun;36(3):339-43. (PMID: 21574780) Thorax. 2009 Jan;64(1):55-61. (PMID: 19052047) Cochrane Database Syst Rev. 2020 Mar 25;3:CD001277. (PMID: 32212422) Respir Med. 2005 May;99(5):553-8. (PMID: 15823451) J Allergy Clin Immunol Pract. 2020 Oct;8(9):2989-2996.e4. (PMID: 32773365) Eur Respir J. 2014 Feb;43(2):343-73. (PMID: 24337046) BMJ Open. 2019 Dec 31;9(12):e032984. (PMID: 31892661) J Psychosom Res. 1985;29(2):199-206. (PMID: 4009520) Eur Respir J. 1999 Jul;14(1):32-8. (PMID: 10489826) Lancet. 2018 Feb 24;391(10122):783-800. (PMID: 29273246) Prim Care Respir J. 2009 Jan;18 Suppl 1:S1-16. (PMID: 19209371) J Allergy Clin Immunol. 2015 Oct;136(4):914-22. (PMID: 25936565) Med Care. 2003 May;41(5):582-92. (PMID: 12719681) Eur Respir J. 2012 Dec;40(6):1324-43. (PMID: 22743675) Complement Ther Clin Pract. 2020 Feb;38:101081. (PMID: 32056817) Trials. 2018 Jun 25;19(1):333. (PMID: 29941003) Eur Respir J. 2007 Jan;29(1):56-62. (PMID: 17050557) Eur Respir J. 2008 Sep;32(3):545-54. (PMID: 18757695) J Clin Epidemiol. 2010 Aug;63(8):e1-37. (PMID: 20346624) |
| فهرسة مساهمة: | Keywords: asthma; breathing exercises; quality of life |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03127059 |
| تواريخ الأحداث: | Date Created: 20220519 Date Completed: 20220908 Latest Revision: 20220915 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9447391 |
| DOI: | 10.1513/AnnalsATS.202111-1228OC |
| PMID: | 35588357 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2325-6621 |
|---|---|
| DOI: | 10.1513/AnnalsATS.202111-1228OC |