دورية أكاديمية
Obesity Induces Disruption of Microvascular Endothelial Circadian Rhythm.
| العنوان: | Obesity Induces Disruption of Microvascular Endothelial Circadian Rhythm. |
|---|---|
| المؤلفون: | Padgett CA; Vascular Biology Center, Augusta, GA, United States., Butcher JT; Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States., Haigh SB; Vascular Biology Center, Augusta, GA, United States., Speese AC; Vascular Biology Center, Augusta, GA, United States., Corley ZL; Vascular Biology Center, Augusta, GA, United States., Rosewater CL; Vascular Biology Center, Augusta, GA, United States., Sellers HG; Vascular Biology Center, Augusta, GA, United States., Larion S; Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, United States., Mintz JD; Vascular Biology Center, Augusta, GA, United States., Fulton DJR; Vascular Biology Center, Augusta, GA, United States.; Department of Pharmacology and Toxicology, Augusta, GA, United States., Stepp DW; Vascular Biology Center, Augusta, GA, United States.; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, United States. |
| المصدر: | Frontiers in physiology [Front Physiol] 2022 May 05; Vol. 13, pp. 887559. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | Obese individuals are at significantly elevated risk of developing cardiovascular disease (CVD). Additionally, obesity has been associated with disrupted circadian rhythm, manifesting in abnormal sleeping and feeding patterns. To date, the mechanisms linking obesity, circadian disruption, and CVD are incompletely understood, and insight into novel mechanistic pathways is desperately needed to improve therapeutic potential and decrease morbidity and mortality. The objective of this study was to investigate the roles of metabolic and circadian disruptions in obesity and assess their contributions in promoting vascular disease. Lean ( db/+ ) and obese ( db/db ) mice were subjected to 12 weeks of constant darkness to differentiate diurnal and circadian rhythms, and were assessed for changes in metabolism, gene expression, and vascular function. Expression of endothelial nitric oxide synthase (eNOS), an essential enzyme for vascular health, was blunted in obesity and correlated with the oscillatory loss of the novel regulator cezanne (OTUD7B). Lean mice subjected to constant darkness displayed marked reduction in vasodilatory capacity, while endothelial dysfunction of obese mice was not further compounded by diurnal insult. Endothelial gene expression of essential circadian clock components was altered in obesity, but imperfectly phenocopied in lean mice housed in constant darkness, suggesting overlapping but separate mechanisms driving endothelial dysfunction in obesity and circadian disruption. Taken together, these data provide insight into the nature of endothelial circadian rhythm in obesity and suggest a distinct mechanism by which obesity causes a unique circadian defect in the vasculature. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Padgett, Butcher, Haigh, Speese, Corley, Rosewater, Sellers, Larion, Mintz, Fulton and Stepp.) |
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| معلومات مُعتمدة: | F31 HL154646 United States HL NHLBI NIH HHS; K01 AG064121 United States AG NIA NIH HHS; R01 HL147159 United States HL NHLBI NIH HHS; T32 HL155011 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: NADPH oxidase; circadian; endothelial NO synthase; obesity; physiology; vascular biology; vascular endothelium |
| تواريخ الأحداث: | Date Created: 20220523 Latest Revision: 20230416 |
| رمز التحديث: | 20230416 |
| مُعرف محوري في PubMed: | PMC9119407 |
| DOI: | 10.3389/fphys.2022.887559 |
| PMID: | 35600313 |
| قاعدة البيانات: | MEDLINE |
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