دورية أكاديمية

An immunomodulatory polypeptide hydrogel for osteochondral defect repair.

التفاصيل البيبلوغرافية
العنوان: An immunomodulatory polypeptide hydrogel for osteochondral defect repair.
المؤلفون: Yang M; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Zhang ZC; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China., Yuan FZ; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Deng RH; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Yan X; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Mao FB; Institute of Medicine Innovation and Research Peking University Third Hospital, Beijing, 100191, China., Chen YR; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Lu H; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China., Yu JK; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China.
المصدر: Bioactive materials [Bioact Mater] 2022 May 13; Vol. 19, pp. 678-689. Date of Electronic Publication: 2022 May 13 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Beijing : Ke Ai Publishing
مستخلص: Osteochondral injury is a common and frequent orthopedic disease that can lead to more serious degenerative joint disease. Tissue engineering is a promising modality for osteochondral repair, but the implanted scaffolds are often immunogenic and can induce unwanted foreign body reaction (FBR). Here, we prepare a polypept(o)ide-based PAA-RGD hydrogel using a novel thiol/thioester dual-functionalized hyperbranched polypeptide P(EG 3 Glu- co -Cys) and maleimide-functionalized polysarcosine under biologically benign conditions. The PAA-RGD hydrogel shows suitable biodegradability, excellent biocompatibility, and low immunogenicity, which together lead to optimal performance for osteochondral repair in New Zealand white rabbits even at the early stage of implantation. Further in vitro and in vivo mechanistic studies corroborate the immunomodulatory role of the PAA-RGD hydrogel, which induces minimum FBR responses and a high level of polarization of macrophages into the immunosuppressive M2 subtypes. These findings demonstrate the promising potential of the PAA-RGD hydrogel for osteochondral regeneration and highlight the importance of immunomodulation. The results may inspire the development of PAA-based materials for not only osteochondral defect repair but also various other tissue engineering and bio-implantation applications.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 The Authors.)
References: Adv Sci (Weinh). 2021 Aug;8(16):e2100446. (PMID: 34117732)
Acta Biomater. 2021 Jul 1;128:150-162. (PMID: 33894346)
J Mater Chem B. 2015 Dec 14;3(46):8921-8938. (PMID: 32263026)
ACS Cent Sci. 2019 Feb 27;5(2):229-236. (PMID: 30834311)
Nat Commun. 2021 Jan 25;12(1):562. (PMID: 33495467)
Front Bioeng Biotechnol. 2022 Jan 11;9:812383. (PMID: 35087809)
Osteoarthritis Cartilage. 2020 May;28(5):555-561. (PMID: 31982565)
Biomaterials. 2021 Nov;278:121131. (PMID: 34543785)
Adv Drug Deliv Rev. 2020 Dec;167:109-120. (PMID: 32553685)
Acta Biomater. 2019 Jul 15;93:180-191. (PMID: 30926580)
Adv Drug Deliv Rev. 2021 Nov;178:113995. (PMID: 34606944)
Biomaterials. 2018 Sep;178:728-737. (PMID: 29428163)
J Control Release. 2016 Dec 28;244(Pt B):184-193. (PMID: 27369864)
Nat Commun. 2021 Oct 4;12(1):5810. (PMID: 34608139)
Bone Joint Res. 2014 Apr 02;3(4):89-94. (PMID: 24695750)
Biomater Sci. 2020 Jun 21;8(12):3248-3269. (PMID: 32490441)
Am J Sports Med. 2022 Jan 20;:3635465211063901. (PMID: 35049404)
Bioact Mater. 2021 Jul 14;9:221-238. (PMID: 34820567)
ACS Appl Mater Interfaces. 2021 Dec 8;13(48):57043-57057. (PMID: 34806361)
Bioconjug Chem. 2019 Jun 19;30(6):1604-1616. (PMID: 31045353)
Macromol Rapid Commun. 2010 Jul 1;31(13):1148-54. (PMID: 21590868)
Adv Sci (Weinh). 2019 Jun 11;6(15):1900867. (PMID: 31406678)
Nat Protoc. 2016 Oct;11(10):1775-81. (PMID: 27583639)
Angew Chem Int Ed Engl. 2020 Jun 8;59(24):9586-9593. (PMID: 32167640)
Biomaterials. 2021 Jan;268:120602. (PMID: 33360302)
Biomacromolecules. 2020 Mar 9;21(3):1243-1253. (PMID: 32045224)
Front Cell Dev Biol. 2021 Mar 25;9:655440. (PMID: 33842484)
Bioact Mater. 2021 May 14;6(12):4531-4541. (PMID: 34027238)
Cell Transplant. 2012;21(11):2397-405. (PMID: 22507530)
Acta Biomater. 2021 Oct 1;133:4-16. (PMID: 33775905)
Mol Pharm. 2018 May 7;15(5):1878-1891. (PMID: 29590755)
Acta Biomater. 2021 Jul 1;128:42-59. (PMID: 33857694)
J Am Chem Soc. 2018 Jan 24;140(3):1170-1178. (PMID: 29262256)
Nat Commun. 2019 Apr 12;10(1):1696. (PMID: 30979900)
Chem Rev. 2021 Sep 22;121(18):11238-11304. (PMID: 33856196)
Am J Sports Med. 2014 Mar;42(3):592-601. (PMID: 24327479)
Bioact Mater. 2017 Sep 06;3(1):118-128. (PMID: 29744449)
Tissue Eng Part A. 2015 Feb;21(3-4):486-97. (PMID: 25203687)
J Orthop Translat. 2021 Oct 11;30:93-102. (PMID: 34722152)
Macromol Biosci. 2011 Dec 8;11(12):1684-92. (PMID: 21932335)
Nat Rev Mater. 2020 Jan;5(1):20-43. (PMID: 34123409)
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3957-61. (PMID: 25656851)
Bioconjug Chem. 2018 Jul 18;29(7):2232-2238. (PMID: 29863329)
Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9984-7. (PMID: 27410669)
Front Pharmacol. 2020 Apr 03;11:404. (PMID: 32308625)
Bioact Mater. 2021 May 28;6(12):4830-4855. (PMID: 34136726)
Nat Rev Drug Discov. 2019 Apr;18(4):273-294. (PMID: 30542076)
Bioact Mater. 2021 Mar 19;6(10):3396-3410. (PMID: 33842736)
Adv Funct Mater. 2020 Sep 10;30(37):. (PMID: 33841061)
Biomacromolecules. 2020 Feb 10;21(2):566-580. (PMID: 31846304)
ACS Nano. 2019 Aug 27;13(8):9595-9606. (PMID: 31381856)
Nature. 2002 May 23;417(6887):424-8. (PMID: 12024209)
NPJ Regen Med. 2021 Mar 19;6(1):14. (PMID: 33741999)
Biomaterials. 2020 Feb;232:119679. (PMID: 31865191)
Acta Biomater. 2018 Jun;73:103-111. (PMID: 29684624)
J Orthop Translat. 2019 Jan 29;17:3-14. (PMID: 31194027)
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9132-9140. (PMID: 32058692)
Adv Healthc Mater. 2018 Aug;7(15):e1800020. (PMID: 29869375)
Front Bioeng Biotechnol. 2021 Dec 15;9:773636. (PMID: 34976971)
J Colloid Interface Sci. 2016 Dec 1;483:201-210. (PMID: 27552428)
Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. (PMID: 20648499)
Chem Sci. 2019 Mar 6;10(14):4048-4053. (PMID: 31015945)
فهرسة مساهمة: Keywords: Foreign-body reaction; Immunoregulation; Mesenchymal stem cells; Osteochondral regeneration; Polypeptide hydrogel
تواريخ الأحداث: Date Created: 20220523 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9112113
DOI: 10.1016/j.bioactmat.2022.05.008
PMID: 35600970
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-199X
DOI:10.1016/j.bioactmat.2022.05.008