دورية أكاديمية
An immunomodulatory polypeptide hydrogel for osteochondral defect repair.
العنوان: | An immunomodulatory polypeptide hydrogel for osteochondral defect repair. |
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المؤلفون: | Yang M; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Zhang ZC; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China., Yuan FZ; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Deng RH; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Yan X; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Mao FB; Institute of Medicine Innovation and Research Peking University Third Hospital, Beijing, 100191, China., Chen YR; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China., Lu H; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China., Yu JK; Department of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, 100191, China.; Institute of Sports Medicine of Peking University, Beijing, 100191, China. |
المصدر: | Bioactive materials [Bioact Mater] 2022 May 13; Vol. 19, pp. 678-689. Date of Electronic Publication: 2022 May 13 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Beijing : Ke Ai Publishing |
مستخلص: | Osteochondral injury is a common and frequent orthopedic disease that can lead to more serious degenerative joint disease. Tissue engineering is a promising modality for osteochondral repair, but the implanted scaffolds are often immunogenic and can induce unwanted foreign body reaction (FBR). Here, we prepare a polypept(o)ide-based PAA-RGD hydrogel using a novel thiol/thioester dual-functionalized hyperbranched polypeptide P(EG Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
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فهرسة مساهمة: | Keywords: Foreign-body reaction; Immunoregulation; Mesenchymal stem cells; Osteochondral regeneration; Polypeptide hydrogel |
تواريخ الأحداث: | Date Created: 20220523 Latest Revision: 20220716 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9112113 |
DOI: | 10.1016/j.bioactmat.2022.05.008 |
PMID: | 35600970 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2452-199X |
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DOI: | 10.1016/j.bioactmat.2022.05.008 |