دورية أكاديمية
Pre-treatment and continuous administration of simvastatin during sepsis improve metabolic parameters and prevent CNS injuries in survivor rats.
| العنوان: | Pre-treatment and continuous administration of simvastatin during sepsis improve metabolic parameters and prevent CNS injuries in survivor rats. |
|---|---|
| المؤلفون: | Catalão CHR; Department of Neurosciences and Behavioral Sciences of Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil. caique@usp.br.; Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP, CEP 14049-900, Brasil. caique@usp.br., de Oliveira Souza A; Department of Chemistry, Institute of Exact and Earth Sciences, Federal University of Mato Grosso, Cuiabá, Brazil., Santos-Junior NN; Department of Neurosciences and Behavioral Sciences of Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., da Costa LHA; Department of Neurosciences and Behavioral Sciences of Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Dos Santos JR; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Alberici LC; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Rocha MJA; Department of Psychology, Faculty of Philosophy, Sciences and Letters at Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil. |
| المصدر: | Molecular and cellular biochemistry [Mol Cell Biochem] 2022 Nov; Vol. 477 (11), pp. 2657-2667. Date of Electronic Publication: 2022 May 23. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial, Veterinary |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: The Hague, Dr. W. Junk B. V. Publishers. |
| مواضيع طبية MeSH: | Sepsis*/drug therapy , Simvastatin*/pharmacology, Animals ; Rats ; Cytokines/metabolism ; Disease Models, Animal ; Gliosis ; Survivors |
| مستخلص: | Sepsis causes overproduction of inflammatory cytokines, organ dysfunction, and cognitive impairment in survivors. In addition to inflammation, metabolic changes occur according to the stage and severity of the disease. Understanding the role and place of metabolic disturbances in the pathophysiology of sepsis is essential to evaluate the framework of septic patients, predict the syndrome progress, and define the treatment strategies. We investigated the effect of simvastatin on the disease time course and on metabolic alterations, especially with respect to their possible consequences in the CNS of surviving rats. The animals of this study were weighed daily and followed for 10 days to determine the survival rate. In the first experiment, control or cecal ligation and puncture (CLP)-animals were randomized in 24 h, 48 h, and 10 days after septic induction, for bacterial load determination and quantification of cytokines. In the second experiment, control or CLP-animals were treated or not with simvastatin and randomized in the same three time points for cytokines quantification and assessment of their body metabolism and locomotor activity (at 48 h and 10 days), as well as the evaluation of cytoarchitecture and astrogliosis (at 10 days). The CLP-rats treated with simvastatin showed a reduction in plasma cytokines and improvement in metabolic parameters and locomotor activity, followed by minor alterations compatible with apoptosis and astrogliosis in the hippocampus and prefrontal cortex. These results suggest that the anti-inflammatory effect of simvastatin plays a crucial role in restoring energy production, maintaining a hypermetabolic state necessary for the recovery and survival of these CLP-rats. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | 2017/12462-0 Fundação de Amparo à Pesquisa do Estado de São Paulo; Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: Cytokines; Experimental sepsis; Glia; HMG-CoA inhibitors; Metabolic disorders; Metabolism |
| المشرفين على المادة: | 0 (Cytokines) AGG2FN16EV (Simvastatin) |
| تواريخ الأحداث: | Date Created: 20220523 Date Completed: 20221103 Latest Revision: 20221103 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s11010-022-04463-8 |
| PMID: | 35604517 |
| قاعدة البيانات: | MEDLINE |
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