دورية أكاديمية
أعرض في EDS

Gut microbiota composition does not associate with toxoplasma infection in rats.

التفاصيل البيبلوغرافية
العنوان: Gut microbiota composition does not associate with toxoplasma infection in rats.
المؤلفون: Taggart PL; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, South Australia, Australia.; Vertebrate Pest Research Unit, Department of Primary Industries NSW, Queanbeyan, New South Wales, Australia.; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales, Australia., Liddicoat C; College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.; School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia., Tong WH; School of Biological Sciences, Nanyang Technological University (SBS-NTU), Singapore, Singapore., Breed MF; College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia., Weinstein P; School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia., Wheeler D; Chief Scientist Unit, Department of Primary Industries NSW, Orange, New South Wales, Australia., Vyas A; School of Biological Sciences, Nanyang Technological University (SBS-NTU), Singapore, Singapore.
المصدر: Molecular ecology [Mol Ecol] 2022 Jul; Vol. 31 (14), pp. 3963-3970. Date of Electronic Publication: 2022 Jun 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992-
مواضيع طبية MeSH: Gastrointestinal Microbiome*/genetics , Toxoplasma*/genetics, Animals ; Bacteria ; Female ; Inflammation/microbiology ; Inflammation/parasitology ; Male ; RNA, Ribosomal, 16S/genetics ; Rats
مستخلص: Toxoplasma infection in intermediate host species closely associates with inflammation. This association has led to suggestions that the behavioural changes associated with infection may be indirectly driven by the resulting sustained inflammation rather than a direct behavioural manipulation by the parasite. If this is correct, sustained inflammation in chronically infected rodents should present as widespread differences in the gastrointestinal microbiota due to the dependency between the composition of these microbiota and sustained inflammation. We conducted a randomized controlled experiment in rats that were assigned to a Toxoplasma-treatment, placebo-treatment or negative control group. We euthanised rats during the chronic phase of infection, collected their caecal stool samples and sequenced the V3-V4 region of the 16S rRNA gene to characterize the bacterial community in these samples. Toxoplasma infection did not induce widespread differences in the bacterial community composition of the gastrointestinal tract of rats. Rather, we found sex differences in the bacterial community composition of rats. We conclude that it is unlikely that sustained inflammation is the mechanism driving the highly specific behavioural changes observed in Toxoplasma-positive rats.
(© 2022 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: toxoplasma; behavioural manipulation; inflammation; microbiome; microbiota; parasite
سلسلة جزيئية: Dryad 10.5061/dryad.c866t1g7z
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20220527 Date Completed: 20220713 Latest Revision: 20221015
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9546062
DOI: 10.1111/mec.16552
PMID: 35621391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-294X
DOI:10.1111/mec.16552