دورية أكاديمية
أعرض في EDS

Differences in Characteristics of T-Cell Immunity to SARS-CoV-2 in Clinically Healthy Subjects.

التفاصيل البيبلوغرافية
العنوان: Differences in Characteristics of T-Cell Immunity to SARS-CoV-2 in Clinically Healthy Subjects.
المؤلفون: Sushentseva NN; St. Petersburg City Hospital No. 40, Sestroretsk, Russia. navicula@yandex.ru., Popov OS; St. Petersburg City Hospital No. 40, Sestroretsk, Russia., Polkovnikova IA; St. Petersburg City Hospital No. 40, Sestroretsk, Russia., Al'pako SV; St. Petersburg City Hospital No. 40, Sestroretsk, Russia., Shcherbak SG; St. Petersburg City Hospital No. 40, Sestroretsk, Russia.; St. Petersburg State University, St. Petersburg, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 May; Vol. 173 (1), pp. 133-138. Date of Electronic Publication: 2022 May 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: COVID-19* , SARS-CoV-2*, Antibodies, Viral ; Healthy Volunteers ; Humans ; Immunity, Humoral ; Spike Glycoprotein, Coronavirus ; T-Lymphocytes
مستخلص: We studied the differences in the characteristics of T-cell immunity in clinically healthy volunteers of three groups: "no previous COVID-19, not vaccinated", "recovered", and "vaccinated" as well as the relationship between the presence of IFNγ-releasing T cells in response to stimulation with peptide pools overlapping the main S, N, M, ORF3, and ORF7 protein sequences and the presence of IgG to the SARS-CoV-2 S protein. In the "no previous COVID-19, non-vaccinated" group, T cells specific to both S protein and other virus proteins were absent in 95% subjects. In the "recovered from COVID-19" group, T cells specific to the spike protein were present in samples from 39% subjects. In the same group, T-cell immunity to other viral proteins was present in 58% subjects. In vaccinated subjects, specific T cells responding to stimulation with S protein peptides were found in 47% cases and Т cells specific to N, M, ORF3, ORF7 proteins were detected in only 22% subjects.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
References: J Clin Invest. 2020 May 1;130(5):2620-2629. (PMID: 32217835)
Cell Mol Immunol. 2021 Oct;18(10):2307-2312. (PMID: 34471260)
J Clin Invest. 2020 Sep 1;130(9):4694-4703. (PMID: 32463803)
Immunity. 2021 Jan 12;54(1):14-18. (PMID: 33406391)
Nat Immunol. 2020 Nov;21(11):1336-1345. (PMID: 32887977)
Clin Immunol. 2020 Aug;217:108486. (PMID: 32479985)
Oxf Open Immunol. 2021 Feb 23;2(1):iqab006. (PMID: 38626271)
Nature. 2020 Aug;584(7821):457-462. (PMID: 32668444)
Nature. 2021 Aug;596(7872):417-422. (PMID: 34192737)
Cell. 2021 Feb 18;184(4):861-880. (PMID: 33497610)
Nat Med. 2021 Jul;27(7):1280-1289. (PMID: 34017137)
Sci Immunol. 2020 Jul 17;5(49):. (PMID: 32680954)
Nat Med. 2021 May;27(5):904-916. (PMID: 33879890)
Cell. 2020 Jun 25;181(7):1489-1501.e15. (PMID: 32473127)
JCI Insight. 2020 Oct 15;5(20):. (PMID: 32937615)
Sci Immunol. 2020 Jun 26;5(48):. (PMID: 32591408)
Nat Commun. 2021 Jun 7;12(1):3406. (PMID: 34099652)
Cell. 2021 Jan 7;184(1):169-183.e17. (PMID: 33296701)
Cell Rep. 2021 Feb 9;34(6):108728. (PMID: 33516277)
Nat Rev Immunol. 2020 Sep;20(9):529-536. (PMID: 32728222)
فهرسة مساهمة: Keywords: COVID-19; IgG SARS-CoV-2; T-cell immunity; humoral immunity
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Spike Glycoprotein, Coronavirus)
0 (spike protein, SARS-CoV-2)
تواريخ الأحداث: Date Created: 20220527 Date Completed: 20220608 Latest Revision: 20240829
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC9142335
DOI: 10.1007/s10517-022-05508-0
PMID: 35624352
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-022-05508-0