دورية أكاديمية
أعرض في EDS

Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales.

التفاصيل البيبلوغرافية
العنوان: Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales.
المؤلفون: Marimuthu K; National Centre for Infectious Diseases, Singapore, Singapore. kalisvar_marimuthu@ttsh.com.sg.; Tan Tock Seng Hospital, Singapore, Singapore. kalisvar_marimuthu@ttsh.com.sg.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. kalisvar_marimuthu@ttsh.com.sg., Venkatachalam I; Singapore General Hospital, Singapore, Singapore., Koh V; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., Harbarth S; Infection Control Program, WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Perencevich E; Departments of Internal Medicine and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, USA.; Center for Comprehensive Access & Delivery Research and Evaluation, Iowa City Veterans Affairs Medical Center, Iowa City, USA., Cherng BPZ; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Singapore General Hospital, Singapore, Singapore.; DUKE-NUS Medical School, National University of Singapore, Singapore, Singapore., Fong RKC; Changi General Hospital, Singapore, Singapore., Pada SK; Ng Teng Fong General Hospital, Singapore, Singapore., Ooi ST; Khoo Teck Puat Hospital, Singapore, Singapore., Smitasin N; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; National University Hospital and National University Health System, Singapore, Singapore., Thoon KC; KK Women's and Children's Hospital, Singapore, Singapore., Tambyah PA; National University Hospital and National University Health System, Singapore, Singapore., Hsu LY; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; National University of Singapore, Singapore, Singapore., Koh TH; Singapore General Hospital, Singapore, Singapore.; DUKE-NUS Medical School, National University of Singapore, Singapore, Singapore., De PP; Tan Tock Seng Hospital, Singapore, Singapore., Tan TY; Changi General Hospital, Singapore, Singapore., Chan D; Ng Teng Fong General Hospital, Singapore, Singapore., Deepak RN; Khoo Teck Puat Hospital, Singapore, Singapore., Tee NWS; National University Hospital and National University Health System, Singapore, Singapore., Kwa A; Singapore General Hospital, Singapore, Singapore.; Academic Clinical Programme (Medicine), SingHealth Duke-NUS, Singapore, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Cai Y; Singapore General Hospital, Singapore, Singapore.; National University of Singapore, Singapore, Singapore., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; National University of Singapore, Singapore, Singapore., Thevasagayam NM; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., Prakki SRS; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., Xu W; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., Khong WX; Tan Tock Seng Hospital, Singapore, Singapore., Henderson D; Clinical Centre, National Institutes of Health, Bethesda, USA., Stoesser N; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Eyre DW; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Crook D; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ang M; National Centre for Infectious Diseases, Singapore, Singapore., Lin RTP; National Centre for Infectious Diseases, Singapore, Singapore.; National University Hospital and National University Health System, Singapore, Singapore., Chow A; Tan Tock Seng Hospital, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Cook AR; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Teo J; National University Hospital and National University Health System, Singapore, Singapore., Ng OT; National Centre for Infectious Diseases, Singapore, Singapore. oon_tek_ng@ncid.sg.; Tan Tock Seng Hospital, Singapore, Singapore. oon_tek_ng@ncid.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. oon_tek_ng@ncid.sg.
مؤلفون مشاركون: Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group
المصدر: Nature communications [Nat Commun] 2022 Jun 01; Vol. 13 (1), pp. 3052. Date of Electronic Publication: 2022 Jun 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Enterobacteriaceae Infections*/microbiology , Enterobacteriaceae Infections*/transmission , Gammaproteobacteria*/genetics, Bacterial Proteins ; Humans ; Retrospective Studies ; Whole Genome Sequencing ; beta-Lactamases/genetics
مستخلص: Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in the hospital transmit to other patients who stay in the same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals in Singapore, we analysed 779 patients who acquired CPE (1215 CPE isolates) detected by clinical or surveillance cultures. 42.0% met putative clonal transmission criteria, 44.8% met putative plasmid-mediated transmission criteria and 13.2% were unlinked. Only putative clonal transmissions associated with direct ward contact decreased in the second half of the study. Both putative clonal and plasmid-mediated transmission associated with indirect (no temporal overlap in patients' admission period) ward and hospital contact did not decrease during the study period. Indirect ward and hospital contact were identified as independent risk factors associated with clonal transmission. In conclusion, undetected CPE reservoirs continue to evade hospital infection prevention measures. New measures are needed to address plasmid-mediated transmission, which accounted for 50% of CPE dissemination.
(© 2022. The Author(s).)
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فهرسة مساهمة: Investigator: K Marimuthu; I Venkatachalam; BPZ Cherng; RKC Fong; SK Pada; ST Ooi; N Smitasin; KC Thoon; LY Hsu; TH Koh; PP De; TY Tan; D Chan; RN Deepak; NWS Tee; M Ang; RTP Lin; J Teo; OT Ng
المشرفين على المادة: 0 (Bacterial Proteins)
EC 3.5.2.6 (beta-Lactamases)
EC 3.5.2.6 (carbapenemase)
تواريخ الأحداث: Date Created: 20220601 Date Completed: 20220603 Latest Revision: 20220716
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9160272
DOI: 10.1038/s41467-022-30637-5
PMID: 35650193
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-30637-5