دورية أكاديمية
Effectiveness of alteplase infusion for the management of prosthetic mitral valve thrombosis in paediatric age group and proposed algorithm.
| العنوان: | Effectiveness of alteplase infusion for the management of prosthetic mitral valve thrombosis in paediatric age group and proposed algorithm. |
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| المؤلفون: | Mashali MH; Paediatric Cardiology Department, King Faisal Specialist Hospital and Research centre, Jeddah, Saudi Arabia.; Department of Paediatrics, Faculty of medicine, Cairo University, Cairo, Egypt., Ahmad Z; Paediatric Cardiology Department, King Faisal Specialist Hospital and Research centre, Jeddah, Saudi Arabia., Omar Galal M; Paediatric Cardiology Department, King Faisal Specialist Hospital and Research centre, Jeddah, Saudi Arabia., Al-Kouatli A; Paediatric Cardiology Department, King Faisal Specialist Hospital and Research centre, Jeddah, Saudi Arabia. |
| المصدر: | Cardiology in the young [Cardiol Young] 2023 May; Vol. 33 (5), pp. 747-753. Date of Electronic Publication: 2022 Jun 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9200019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-1107 (Electronic) Linking ISSN: 10479511 NLM ISO Abbreviation: Cardiol Young Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Cambridge : Cambridge University Press Original Publication: Chapel Hill, NC : World Publishers, c1991- |
| مواضيع طبية MeSH: | Heart Valve Diseases*/complications , Thrombosis*/etiology , Heart Valve Prosthesis*/adverse effects, Humans ; Child ; Tissue Plasminogen Activator/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Mitral Valve ; Retrospective Studies ; Thrombolytic Therapy ; Hemorrhage/complications ; Hemorrhage/drug therapy |
| مستخلص: | Introduction: The incidence of prosthetic valve implantation is increasing in the paediatric population. Prosthetic valve thrombosis leading to obstruction could potentially be a life-threatening complication. There is a debate regarding optimal management of this complication, and there is limited use of thrombolytic therapy in childhood in the setting of valve thrombosis. Objective: We aim to share our experience of successfully using fibrinolytic therapy in terms of alteplase for paediatric prosthetic mitral valve thrombosis and to propose a management algorithm. Methods: This retrospective analysis of the database was conducted at our hospital including patients who underwent thrombolysis (alteplase) for prosthetic mitral valve thrombosis from June, 2011 to June, 2021. A total of 10 patients with 20 attempts of alteplase infusion were found in our record. Results: Alteplase was successful in 19 attempts to relieve valve thrombosis. The safe and effective dose of alteplase was between 0.1 and 0.3 mg/kg/hour. There were no associated major bleeding complications and alteplase was administered either by central or peripheral line. Conclusion: Thrombolysis by alteplase infusion was found to be successful in relief of prosthetic mitral valve thrombosis in paediatric population without major bleeding complications. |
| فهرسة مساهمة: | Keywords: Alteplase; Prosthetic mitral valve; Thrombosis |
| المشرفين على المادة: | EC 3.4.21.68 (Tissue Plasminogen Activator) 0 (Fibrinolytic Agents) |
| تواريخ الأحداث: | Date Created: 20220603 Date Completed: 20230525 Latest Revision: 20230525 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1017/S1047951122001652 |
| PMID: | 35656568 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1467-1107 |
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| DOI: | 10.1017/S1047951122001652 |