دورية أكاديمية
أعرض في EDS

The clinical and bioinformatics analysis for the role of antihypertension drugs on mortality among patients with hypertension hospitalized with COVID-19.

التفاصيل البيبلوغرافية
العنوان: The clinical and bioinformatics analysis for the role of antihypertension drugs on mortality among patients with hypertension hospitalized with COVID-19.
المؤلفون: Zhao L; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, China., Li Y; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, China., Yi W; Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, China., Yan K; Institute of Cell and Neurobiology, Charité Medical University, Berlin, Germany., Yang C; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Radhakrishnan S; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Li R; Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Tan R; Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China., Fan G; Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China., Dai M; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China., Liu M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Shao NY; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.
المصدر: Journal of medical virology [J Med Virol] 2022 Oct; Vol. 94 (10), pp. 4727-4734. Date of Electronic Publication: 2022 Jun 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: COVID-19*/complications , Hypertension*/complications , Hypertension*/drug therapy , COVID-19 Drug Treatment*, Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Computational Biology ; Humans ; Retrospective Studies ; SARS-CoV-2
مستخلص: Comorbidities such as hypertension could exacerbate symptoms of coronaviral disease 2019 (COVID)-19 infection. Patients with hypertension may receive both anti-COVID-19 and antihypertension therapies when infected with COVID-19. However, it is not clear how different classes of anti-hypertension drugs impact the outcome of COVID-19 treatment. Herein, we explore the association between the inpatient use of different classes of anti-hypertension drugs and mortality among patients with hypertension hospitalized with COVID-19. We totally collected data from 278 patients with hypertension diagnosed with COVID-19 admitted to hospitals in Wuhan from February 1 to April 1, 2020. A retrospective study was conducted and single-cell RNA-sequencing (RNA-Seq) analysis of treatment-related genes was performed. The results showed that Angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) drugs significantly increased the survival rate but the use of angiotensin-converting enzyme inhibitor/β-block/diuretic drugs did not affect the mortality caused by COVID-19. Based on the analysis of four public data sets of single-cell RNA-Seq on COVID-19 patients, we concluded that JUN, LST1 genes may play a role in the effect of ARB on COVID-19-related mortality, whereas CALM1 gene may contribute to the effect of CCB on COVID-19-related mortality. Our results provide guidance on the selection of antihypertension drugs for hypertensive patients infected with COVID-19.
(© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.)
التعليقات: Comment in: J Med Virol. 2023 Jan;95(1):e28319. (PMID: 36397640)
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فهرسة مساهمة: Keywords: Biostatistics & Bioinformatics; Infectious bronchitis virus; SARS coronavirus; Virus classification
المشرفين على المادة: 0 (Angiotensin Receptor Antagonists)
0 (Angiotensin-Converting Enzyme Inhibitors)
0 (Antihypertensive Agents)
0 (Calcium Channel Blockers)
تواريخ الأحداث: Date Created: 20220603 Date Completed: 20220818 Latest Revision: 20230209
رمز التحديث: 20230209
مُعرف محوري في PubMed: PMC9347732
DOI: 10.1002/jmv.27914
PMID: 35656698
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.27914