دورية أكاديمية
Risk factors associated with nonalcoholic fatty liver disease evaluated by elastography in patients with type 2 diabetes.
| العنوان: | Risk factors associated with nonalcoholic fatty liver disease evaluated by elastography in patients with type 2 diabetes. |
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| المؤلفون: | Pozzan R; Disciplina de Diabetes/Serviço de Diabetes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Pena RG; Disciplina de Diabetes/Serviço de Diabetes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Palma CCSSV; Disciplina de Diabetes/Serviço de Diabetes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., de Carvalho Abi-Abib R; Disciplina de Diabetes/Serviço de Diabetes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil, raquelabib80@gmail.com., Terra C; Divisão de Gastroenterologia - Unidade de Fígado, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil., Cobas RA; Disciplina de Diabetes/Serviço de Diabetes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. |
| المصدر: | Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2022 Sept 08; Vol. 66 (4), pp. 452-458. Date of Electronic Publication: 2022 Jun 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, SP : Segmento Farma Editores |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/epidemiology , Elasticity Imaging Techniques*/methods , Non-alcoholic Fatty Liver Disease*/diagnostic imaging, Adult ; Cholesterol, HDL ; Cross-Sectional Studies ; Humans ; Insulin ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Risk Factors |
| مستخلص: | Objective: There is controversy about the indication for nonalcoholic fatty liver disease (NAFLD) screening in patients with type 2 diabetes mellitus (T2D). The present study aims to contribute to NAFLD surveillance in patients with T2D, assessing the association of clinical and biological variables with hepatic stiffness and steatosis. Subjects and Methods: A cross-sectional design was used, with data collection from electronic medical records, including adults with T2D who underwent transient elastography (TE) between June 2018 and December 2019. Liver stiffness and steatosis were evaluated using TE and controlled attenuation parameter (CAP), respectively, with cutoff points > 8 kpa for increased stiffness and > 275 dBm for steatosis. The relationship between clinical variables and elastography results were evaluated by bivariate correlation and multivariate analysis, using SPSS 27. Seventy-nine patients (n = 79) met the inclusion and exclusion criteria. Results: Advanced fibrosis and hepatic steatosis were detected in 17,7% and in 21,5% of the patients, respectively. There was a direct and significant correlation between CAP and BMI, waist circumference, HbA1c, triglycerides levels, and insulin doses and an inverse correlation with HDL. The waist circumference, low levels of HDL cholesterol and the insulin dose maintained a significant association with CAP values in multivariate analysis. Elastography values showed an inverse correlation with HDL and a direct correlation with BMI and insulin dose. The association was only maintained for the insulin dose in multivariate analysis. Conclusion: Our results suggest that clinical factors such as insulin dose, waist circumference, and HDL cholesterol levels could identify T2D patients more likely to present NAFLD. |
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| فهرسة مساهمة: | Keywords: Type 2 diabetes mellitus; controlled attenuation parameter (CAP); elastography; nonalcoholic fatty liver disease |
| المشرفين على المادة: | 0 (Cholesterol, HDL) 0 (Insulin) |
| تواريخ الأحداث: | Date Created: 20220603 Date Completed: 20220912 Latest Revision: 20231207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10697651 |
| DOI: | 10.20945/2359-3997000000492 |
| PMID: | 35657127 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2359-4292 |
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| DOI: | 10.20945/2359-3997000000492 |