دورية أكاديمية
Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
| العنوان: | Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. |
|---|---|
| المؤلفون: | Dhume SH; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada., Connor SA; Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Biology, York University, Toronto, Canada., Mills F; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Tari PK; Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Biology, York University, Toronto, Canada., Au-Yeung SHM; Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Karimi B; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada., Oku S; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.; Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Roppongi RT; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada., Kawabe H; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.; Department of Pharmacology, Gunma University Graduate School of Medicine, Gunma, Japan., Bamji SX; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Wang YT; Division of Neurology, Department of Medicine and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Brose N; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Jackson MF; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada., Craig AM; Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Siddiqui TJ; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, Canada.; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.; The Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.; Program in Biomedical Engineering, University of Manitoba, Winnipeg, Canada. |
| المصدر: | ELife [Elife] 2022 Jun 06; Vol. 11. Date of Electronic Publication: 2022 Jun 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
| مواضيع طبية MeSH: | Neural Cell Adhesion Molecules*/metabolism, Membrane Proteins/*metabolism , Nerve Tissue Proteins/*metabolism, Animals ; Hippocampus/physiology ; Long-Term Potentiation/physiology ; Mice ; Synapses/physiology |
| مستخلص: | LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circuits in mice lacking both Lrrtm1 and Lrrtm2 . We found that LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses on CA1 pyramidal neurons in the developing brain but are not essential for these roles in the mature circuit. Further, they are required for long-term-potentiation in the CA3-CA1 pathway and the dentate gyrus, and for enduring fear memory in both the developing and mature brain. Our data show that LRRTM1 and LRRTM2 regulate synapse development and function in a cell-type and developmental-stage-specific manner, and thereby contribute to the fine-tuning of hippocampal circuit connectivity and plasticity. Competing Interests: SD, SC, FM, PT, SA, BK, SO, RR, HK, SB, YW, MJ, AC, TS No competing interests declared, NB Reviewing editor, eLife (© 2022, Dhume et al.) |
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| معلومات مُعتمدة: | MOP-130526 Canada CIHR; FND-154286 Canada CIHR; FDN-143206 Canada CIHR; MOP-84241 Canada CIHR; MOP-142209 Canada CIHR; PJT-173550 Canada CIHR |
| فهرسة مساهمة: | Keywords: LRRTMs; cognition; hippocampus; mouse; neuroscience; synapse development; synapse organization; synaptic plasticity |
| المشرفين على المادة: | 0 (LRRTM1 protein, mouse) 0 (LRRTM2 protein, mouse) 0 (Membrane Proteins) 0 (Nerve Tissue Proteins) 0 (Neural Cell Adhesion Molecules) |
| تواريخ الأحداث: | Date Created: 20220606 Date Completed: 20220608 Latest Revision: 20220716 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9170246 |
| DOI: | 10.7554/eLife.64742 |
| PMID: | 35662394 |
| قاعدة البيانات: | MEDLINE |
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