دورية أكاديمية
أعرض في EDS

Effect of Corticosteroids on Left Ventricular Function in Patients With Cardiac Sarcoidosis.

التفاصيل البيبلوغرافية
العنوان: Effect of Corticosteroids on Left Ventricular Function in Patients With Cardiac Sarcoidosis.
المؤلفون: Wand AL; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Pavlovic N; Johns Hopkins School of Nursing, Baltimore, Maryland., Duvall C; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Rosen NS; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chasler J; Department of Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland., Griffin JM; Division of Cardiology, Columbia University Irving Medical Center, New York City, New York., Okada DR; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Jefferson A; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chrispin J; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Tandri H; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mathai SC; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sharp M; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Chen ES; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kasper EK; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hays AG; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Gilotra NA; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: naggarw2@jhmi.edu.
المصدر: The American journal of cardiology [Am J Cardiol] 2022 Aug 15; Vol. 177, pp. 108-115. Date of Electronic Publication: 2022 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Excerpta Medica
مواضيع طبية MeSH: Myocarditis* , Sarcoidosis*/complications , Sarcoidosis*/drug therapy , Ventricular Dysfunction, Left*/diagnostic imaging , Ventricular Dysfunction, Left*/drug therapy, Adrenal Cortex Hormones/therapeutic use ; Humans ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left
مستخلص: Cardiac sarcoidosis (CS) is an important cause of cardiomyopathy. The trajectory of left ventricular ejection fraction (LVEF) in patients with CS undergoing treatment remains unclear. Patients with CS who were treated with corticosteroids and who underwent transthoracic echocardiography were studied. Baseline characteristics, treatment, echocardiographic data (including baseline to follow-up change in LVEF), and outcomes were retrospectively evaluated. Among 100 patients, 55 had baseline reduced LVEF (<50%), and 45 had preserved LVEF (≥50%). At follow-up, 82% of patients demonstrated stable or improved LVEF. Change in LVEF was significantly higher in the baseline reduced than in the preserved LVEF group (5% [interquartile range 0 to 15] vs 0% [interquartile range -10% to 5%], p = 0.001). There was no difference in corticosteroid exposure or use of heart failure guideline-directed medical therapy between patients who did experience improvement in LVEF and those who did not experience improvement in LVEF. On multivariable analysis, baseline reduced LVEF (Odds ratio 54.89, 95% confidence interval 3.84 to 785.09, p = 0.003) and complete heart block (Odds ratio 28.88, 95% confidence interval 2.17 to 383.74, p = 0.011) at presentation were significantly associated with reduced LVEF after treatment. In conclusion, most patients with CS treated with corticosteroids maintain or improve LV systolic function. Cardiac characteristics at presentation impact prognosis in CS, despite treatment.
Competing Interests: Disclosures The authors have no conflicts of interest to declare.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
معلومات مُعتمدة: K23 HL148527 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Adrenal Cortex Hormones)
تواريخ الأحداث: Date Created: 20220614 Date Completed: 20220719 Latest Revision: 20230602
رمز التحديث: 20231215
DOI: 10.1016/j.amjcard.2022.04.051
PMID: 35701237
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1913
DOI:10.1016/j.amjcard.2022.04.051