دورية أكاديمية
Blood Lipid Biomarkers in Early Parkinson's Disease and Parkinson's Disease with Mild Cognitive Impairment.
| العنوان: | Blood Lipid Biomarkers in Early Parkinson's Disease and Parkinson's Disease with Mild Cognitive Impairment. |
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| المؤلفون: | Deng X; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Saffari SE; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore., Ng SYE; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Chia N; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Tan JY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Choi X; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Heng DL; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Xu Z; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Tay KY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Au WL; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Liu N; Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore., Ng A; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Tan EK; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Tan LCS; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore. |
| المصدر: | Journal of Parkinson's disease [J Parkinsons Dis] 2022; Vol. 12 (6), pp. 1937-1943. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101567362 Publication Model: Print Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press |
| مواضيع طبية MeSH: | Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/etiology , Parkinson Disease*/complications , Parkinson Disease*/diagnosis, Apolipoprotein A-I ; Apolipoproteins B ; Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Lipids ; Triglycerides |
| مستخلص: | Background: Lipid biomarkers have potential neuroprotective effects in Parkinson's disease (PD) and there is limited evidence in the field. Objective: This study aims to investigate the association between comprehensive blood lipid biomarkers and PD. Methods: A total of 205 PD patients and 102 non-PD subjects were included from Early Parkinson's disease Longitudinal Singapore (PALS) cohort. We investigated 6 serum lipid biomarkers including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo A1), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B). PD patients were further classified into mild cognitive impairment (MCI) and normal cognition (NC) subgroups. We conducted a cross-sectionals study to examine the association between lipids and PD and further explored the relationship between lipids and PD-MCI. Results: PD patients had significantly lower level of lipid panel including TC, TG, HDL-C, Apo A1, LDL-C, and Apo B (all p < 0.05). TC, TG, Apo A1, and Apo B levels were independent protective factors (p < 0.05) for PD in the logistic regression model. PD-MCI group had significantly higher mean TC, TG, and Apo A1 levels compared to PD-NC group. Higher TC, TG, and Apo A1 levels were independent risk factors (p < 0.05) for PD-MCI. Conclusion: We demonstrated that PD patients had significantly lower levels of lipid biomarkers while PD-MCI patients had higher levels of TC, TG, and Apo A1. TC, TG, and Apo A1 may be useful biomarkers for PD-MCI. |
| فهرسة مساهمة: | Keywords: Parkinson’s disease; blood lipid biomarkers; cognitive impairment |
| المشرفين على المادة: | 0 (Apolipoprotein A-I) 0 (Apolipoproteins B) 0 (Biomarkers) 0 (Cholesterol, HDL) 0 (Cholesterol, LDL) 0 (Lipids) 0 (Triglycerides) |
| تواريخ الأحداث: | Date Created: 20220620 Date Completed: 20220908 Latest Revision: 20221003 |
| رمز التحديث: | 20240829 |
| DOI: | 10.3233/JPD-213135 |
| PMID: | 35723114 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1877-718X |
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| DOI: | 10.3233/JPD-213135 |