دورية أكاديمية
أعرض في EDS

Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons.

التفاصيل البيبلوغرافية
العنوان: Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons.
المؤلفون: Langlois LD; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA., Selvaraj P; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Anatomy, Physiology and Genetics, Bethesda, MD 20814, USA., Simmons SC; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA., Gouty S; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA., Zhang Y; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Anatomy, Physiology and Genetics, Bethesda, MD 20814, USA., Nugent FS; Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.
المصدر: IBRO neuroscience reports [IBRO Neurosci Rep] 2022 Feb 09; Vol. 12, pp. 157-162. Date of Electronic Publication: 2022 Feb 09 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101775148 Publication Model: eCollection Cited Medium: Internet ISSN: 2667-2421 (Electronic) Linking ISSN: 26672421 NLM ISO Abbreviation: IBRO Neurosci Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier B.V., [2021]-
مستخلص: Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory deficits in affected individuals [1]. Although most studies have investigated the role of hippocampal synaptic dysfunction in earlier time points following a single injury, the long-lasting effects of mTBI on hippocampal synaptic transmission following multiple brain concussions have not been well-elucidated. Using a repetitive closed head injury (3XCHI) mouse model of mTBI, we examined the alteration of spontaneous synaptic transmission onto hippocampal CA1 pyramidal neurons by recording spontaneous excitatory AMPA receptor (AMPAR)- and inhibitory GABA A R-mediated postsynaptic currents (sEPSCs and sIPSCs, respectively) in adult male mice 2-weeks following the injury. We found that mTBI potentiated postsynaptic excitatory AMPAR synaptic function while depressed postsynaptic inhibitory GABA A R synaptic function in CA1 pyramidal neurons. Additionally, mTBI slowed the decay time of AMPAR currents while shortened the decay time of GABA A R currents suggesting changes in AMPAR and GABA A R subunit composition by mTBI. On the other hand, mTBI reduced the frequency of sEPSCs while enhanced the frequency of sIPSCs resulting in a lower ratio of sEPSC/sIPSC frequency in CA1 pyramidal neurons of mTBI animals compared to sham animals. Altogether, our results suggest that mTBI induces persistent postsynaptic modifications in AMPAR and GABA A R function and their synaptic composition in CA1 neurons while triggering a compensatory shift in excitation/inhibition (E/I) balance of presynaptic drives towards more inhibitory synaptic drive to hippocampal CA1 cells. The persistent mTBI-induced CA1 synaptic dysfunction and E/I imbalance could contribute to deficits in hippocampal plasticity that underlies long-term hippocampal-dependent learning and memory deficits in mTBI patients long after the initial injury.
Competing Interests: The authors have no competing interests to declare.
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معلومات مُعتمدة: R21 NS120628 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: CA1; Electrophysiology; Hippocampus; Mild traumatic brain injury; Synaptic transmission; mTBI
تواريخ الأحداث: Date Created: 20220624 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9210462
DOI: 10.1016/j.ibneur.2022.02.002
PMID: 35746968
قاعدة البيانات: MEDLINE
الوصف
تدمد:2667-2421
DOI:10.1016/j.ibneur.2022.02.002