دورية أكاديمية

Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential.

التفاصيل البيبلوغرافية
العنوان: Detam 1 black soybean against cisplatin-induced acute ren failure on rat model via antioxidant, antiinflammatory and antiapoptosis potential.
المؤلفون: Widowati W; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Prahastuti S; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Hidayat M; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Hasianna ST; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Wahyudianingsih R; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Eltania TF; Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia., Azizah AM; Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia., Aviani JK; Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia., Subangkit M; Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, IPB University, Jl. Agathis No. 1, IPB University Darmaga Campus, Bogor, 16680, West Java, Indonesia., Handayani RAS; Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia., Kusuma HSW; Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.
المصدر: Journal of traditional and complementary medicine [J Tradit Complement Med] 2022 Jan 13; Vol. 12 (4), pp. 426-435. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University Country of Publication: Netherlands NLM ID: 101605474 Publication Model: eCollection Cited Medium: Print ISSN: 2225-4110 (Print) Linking ISSN: 22254110 NLM ISO Abbreviation: J Tradit Complement Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier B.V. on behalf of the Center for Food and Biomolecules, National Taiwan University
Original Publication: Philadelphia, PA : [Taipei] : Wolters Kluwer Health, Medknow ; Committee on Chinese Medicine and Pharmacy
مستخلص: Background and Aim: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean ( Glycine max L. Merr.) has been reported contain high levels of phenolics and anthocyanins that has antioxidant activity. This study aims to determine the effect of ethanol extract of black soybean (EEBS) against cisplatin-induced nephrotoxicity in rats.
Experimental Procedure: Cisplatin-induced nephrotoxicity rats treated with EEBS and the blood samples taken on days 0, 9, and 18. The effects of EEBS was evaluated by determining Interferon-γ (IFN-γ), Caspase-3 (Casp-3), and Interleukin-1β (IL-1β) expression using immunohistochemistry (IHC), blood urea nitrogen (BUN), Uric Acid (UA) content and catalase (CAT) content in the blood plasma with colorimetric assay kit.
Results and Conclusion: Based on the results, EEBS treatment had successfully reduced pro-inflammatory cytokines IL-1β and IFN-γ, and improved physiological condition by lowering BUN and UA content while increasing CAT activity. No significant effect was found in Casp-3 expression. EEBS has potential to improve acute renal failure condition through inflammatory suppression and renal function improvement.
Competing Interests: There is no conflict of interest.
(© 2022 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.)
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فهرسة مساهمة: Keywords: Blood urea nitrogen; Catalase; Fibronectin; Glycine max L. Merr.; Nephrotoxicity
تواريخ الأحداث: Date Created: 20220624 Latest Revision: 20240830
رمز التحديث: 20240830
مُعرف محوري في PubMed: PMC9209860
DOI: 10.1016/j.jtcme.2022.01.004
PMID: 35747350
قاعدة البيانات: MEDLINE
الوصف
تدمد:2225-4110
DOI:10.1016/j.jtcme.2022.01.004