دورية أكاديمية
The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study.
| العنوان: | The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study. |
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| المؤلفون: | da Silva KE; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA., Tanmoy AM; Child Health Research Foundation, Dhaka, Bangladesh; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands., Pragasam AK; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Iqbal J; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan., Sajib MSI; Child Health Research Foundation, Dhaka, Bangladesh; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK., Mutreja A; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Tamrakar D; Department of Community Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu, Nepal., Qamar FN; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan., Dougan G; Department of Medicine, Cambridge Biomedical Campus, Cambridge, UK; University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Bogoch I; Department of Medicine, University of Toronto, Toronto, ON, Canada., Seidman JC; Applied Epidemiology, Sabin Vaccine Institute, Washington, DC, USA., Shakya J; Research and Development Division, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu, Nepal; Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal., Vaidya K; Research and Development Division, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu, Nepal., Carey ME; Department of Medicine, Cambridge Biomedical Campus, Cambridge, UK., Shrestha R; Department of Pharmacology, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu, Nepal., Irfan S; Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan., Baker S; Department of Medicine, Cambridge Biomedical Campus, Cambridge, UK; University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Luby SP; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA., Cao Y; Department of Geography, The University of Hong Kong, Hong Kong Special Administrative Region, China., Dyson ZA; Department of Medicine, Cambridge Biomedical Campus, Cambridge, UK; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Garrett DO; Applied Epidemiology, Sabin Vaccine Institute, Washington, DC, USA., John J; Department of Community Health, Christian Medical College, Vellore, India., Kang G; The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India., Hooda Y; Child Health Research Foundation, Dhaka, Bangladesh; MRC Laboratory Molecular Biology, Cambridge, UK., Saha SK; Child Health Research Foundation, Dhaka, Bangladesh; Department of Microbiology, Dhaka Shishu Hospital, Dhaka, Bangladesh., Saha S; Child Health Research Foundation, Dhaka, Bangladesh., Andrews JR; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA. Electronic address: jandr@stanford.edu. |
| المصدر: | The Lancet. Microbe [Lancet Microbe] 2022 Aug; Vol. 3 (8), pp. e567-e577. Date of Electronic Publication: 2022 Jun 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Elsevier Ltd., [2020]- |
| مواضيع طبية MeSH: | Anti-Infective Agents*/pharmacology , Quinolones*/pharmacology , Typhoid Fever*/drug therapy, Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Drug Resistance, Bacterial/genetics ; Fluoroquinolones/pharmacology ; Genomics ; Humans ; Prospective Studies ; Salmonella typhi/genetics |
| مستخلص: | Background: The emergence of increasingly antimicrobial-resistant Salmonella enterica serovar Typhi (S Typhi) threatens to undermine effective treatment and control. Understanding where antimicrobial resistance in S Typhi is emerging and spreading is crucial towards formulating effective control strategies. Methods: In this genomic epidemiology study, we sequenced the genomes of 3489 S Typhi strains isolated from prospective enteric fever surveillance studies in Nepal, Bangladesh, Pakistan, and India (between 2014 and 2019), and combined these with a global collection of 4169 S Typhi genome sequences isolated between 1905 and 2018 to investigate the temporal and geographical patterns of emergence and spread of antimicrobial-resistant S Typhi. We performed non-parametric phylodynamic analyses to characterise changes in the effective population size of fluoroquinolone-resistant, extensively drug-resistant (XDR), and azithromycin-resistant S Typhi over time. We inferred timed phylogenies for the major S Typhi sublineages and used ancestral state reconstruction methods to estimate the frequency and timing of international and intercontinental transfers. Findings: Our analysis revealed a declining trend of multidrug resistant typhoid in south Asia, except for Pakistan, where XDR S Typhi emerged in 2016 and rapidly replaced less-resistant strains. Mutations in the quinolone-resistance determining region (QRDR) of S Typhi have independently arisen and propagated on at least 94 occasions, nearly all occurring in south Asia. Strains with multiple QRDR mutations, including triple mutants with high-level fluoroquinolone resistance, have been increasing in frequency and displacing strains with fewer mutations. Strains containing acrB mutations, conferring azithromycin resistance, emerged in Bangladesh around 2013 and effective population size of these strains has been steadily increasing. We found evidence of frequent international (n=138) and intercontinental transfers (n=59) of antimicrobial-resistant S Typhi, followed by local expansion and replacement of drug-susceptible clades. Interpretation: Independent acquisition of plasmids and homoplastic mutations conferring antimicrobial resistance have occurred repeatedly in multiple lineages of S Typhi, predominantly arising in south Asia before spreading to other regions. Funding: Bill & Melinda Gates Foundation. Competing Interests: Declaration of interests IB has consulted for BlueDot, a social benefit corporation that tracks the spread of emerging infectious diseases. SPL reports travel fees from the Bill & Melinda Gates Foundation. ZAD is a coordinator and founding member of the Global Typhoid Genomics Consortium and reports grants from EU Horizon 2020 for typhoid research outside the submitted work. All other authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.) |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) 0 (Fluoroquinolones) 0 (Quinolones) 83905-01-5 (Azithromycin) |
| تواريخ الأحداث: | Date Created: 20220624 Date Completed: 20220802 Latest Revision: 20220831 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9329132 |
| DOI: | 10.1016/S2666-5247(22)00093-3 |
| PMID: | 35750070 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2666-5247 |
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| DOI: | 10.1016/S2666-5247(22)00093-3 |