دورية أكاديمية
أعرض في EDS

Outcomes of infants with pulmonary atresia with intact ventricular septum listed for heart transplantation: A multi-institutional study.

التفاصيل البيبلوغرافية
العنوان: Outcomes of infants with pulmonary atresia with intact ventricular septum listed for heart transplantation: A multi-institutional study.
المؤلفون: Joong A; Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA., Zuckerman WA; Division of Pediatric Cardiology, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University, New York, New York, USA., Koehl D; Kirklin Institute for Research in Surgical Outcomes, University of Alabama, Birmingham, Alabama, USA., Cantor R; Kirklin Institute for Research in Surgical Outcomes, University of Alabama, Birmingham, Alabama, USA., Alejos JC; Division of Pediatric Cardiology, UCLA Mattel Children's Hospital, University of California, Los Angeles, California, USA., Ameduri RK; Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota, USA., Boyle GJ; Department of Pediatric Cardiology, Cleveland Clinic Children's Hospital, Cleveland, Ohio, USA., Rothkopf AC; Division of Pediatric Cardiology, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University, New York, New York, USA., Kirklin JK; Kirklin Institute for Research in Surgical Outcomes, University of Alabama, Birmingham, Alabama, USA., Gajarski RJ; Division of Pediatric Cardiology, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA.
المصدر: Pediatric transplantation [Pediatr Transplant] 2022 Nov; Vol. 26 (7), pp. e14338. Date of Electronic Publication: 2022 Jun 29.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997-
مواضيع طبية MeSH: Heart Defects, Congenital* , Heart Transplantation* , Pulmonary Atresia*/surgery , Ventricular Septum*, Child ; Humans ; Infant ; Retrospective Studies ; Treatment Outcome
مستخلص: Background: Management of infants with pulmonary atresia/intact ventricular septum (PA/IVS) is variable. Because of higher mortality in more severe forms, heart transplant (HT) is an acceptable approach, but waitlist and post-transplant outcomes are unclear. This study compared outcomes of infants with PA/IVS vs. other single ventricle (SV) anatomies listed for HT.
Methods: Data from the Pediatric Heart Transplant Society (1993-2018) were analyzed for survival and risk factors for mortality.
Results: Of 1617 SV infants, 300 had PA/IVS (19%) and 1317 had other SV (81%). Overall, 1-, 5-, and 10-year survival was higher among PA/IVS (74%, 65%, 61%) versus other SV infants (62%, 54%, 50%, p = .004). While waitlist mortality was similar between groups (p = .09), PA/IVS was an independent predictor of improved waitlist survival (HR 0.68, p = .03), and PA/IVS infants had higher incidence of waitlist removal (8% vs. 5.5%, p = .03), most commonly for being "too well." Post-transplant survival was superior among PA/IVS versus other SV infants (1- and 5-year survival 93% and 81% vs. 80% and 71%, p < .0001). Risk factors for PA/IVS waitlist mortality (2008-2018) included extracorporeal membrane oxygenation and mechanical ventilation. Prior aortopulmonary (AP) shunt among PA/IVS infants was associated with improved waitlist survival.
Conclusions: Overall survival among PA/IVS infants listed for HT exceeds that of other SV infants with PA/IVS identified as an independent predictor of improved waitlist and post-transplant survival. Prior AP shunt among listed PA/IVS infants was associated with improved waitlist outcomes, though, which may reflect a listing selection bias.
(© 2022 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: congenital heart disease; pediatric heart transplant; single ventricle
SCR Disease Name: Pulmonary Atresia with Intact Ventricular Septum
تواريخ الأحداث: Date Created: 20220630 Date Completed: 20221012 Latest Revision: 20221028
رمز التحديث: 20240829
DOI: 10.1111/petr.14338
PMID: 35768886
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3046
DOI:10.1111/petr.14338