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Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.

التفاصيل البيبلوغرافية
العنوان: Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.
المؤلفون: Abu-Elfotuh K; Pharmacology and Toxicology Department (Girls), Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Hamdan AME; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia. Electronic address: a_hamdan@ut.edu.sa., Abbas AN; University of Sulaimanyia, College of Dentistry, kurdistan, Iraq., Alahmre ATS; Pharmacy intern at King Salman Northwest Armed Force Hospital, Tabuk, Saudi Arabia., Elewa MAF; Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt., Masoud RAE; Forensic Medicine and Clinical Toxicology Department, Faculty of medicine for girls, Al-Azhar University, Cairo, Egypt., Ali AA; Pharmacology and Toxicology Department (Girls), Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Othman M; Lecturer, Department of anatomy, Faculty of Medicine, King Salman International University, El-Tur Campus, Saini, Egypt., Kamal MM; Pharmacology and Toxicology Department (Girls), Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Hassan FAM; Biochemistry and molecular biology Department, Faculty of Pharmacy, Al-Azhar, University, Cairo, Egypt., Khalil MG; Pharmacology and Toxicology Department, Modern University for Technology and Information, Cairo, Egypt., El-Sisi AM; Biochemistry and Molecular Biology Department (boys), Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; Biochemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt., Abdel Hady MMM; Department of Pharmacology, Faculty of Pharmacy, Qantra University, Sinai, Egypt., Abd-Elhaleim El Azazy MK; Department of Biochemistry and Nutrition, Ain shams university, Cairo, Egypt., Awny MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, Cairo, Egypt., Wahid A; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Sep; Vol. 153, pp. 113330. Date of Electronic Publication: 2022 Jun 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Niacin*/pharmacology , Parkinson Disease*/drug therapy, Acetylcholinesterase ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Glycogen Synthase Kinase 3 beta ; Hydrolyzable Tannins ; Manganese/pharmacology ; Neuroprotection ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley ; Vinca Alkaloids ; Vitamin E/pharmacology
مستخلص: The current study investigated the neuroprotective activity of some drugs and nutriceuticals with antioxidant and anti-inflammatory potential on the pathogenesis of Parkinson's disease (PD). Rats were categorized into seven groups: Rats received tween80 daily for 5 weeks as a control group, MnCl 2 (10 mg/kg, i.p) either alone (group II) or in combination with vinpocetine (VIN) (20 mg/kg) (group III), punicalagin (PUN) (30 mg/kg) (group IV), niacin (85 mg/kg) (group V), vitamin E (Vit E) (100 mg/kg) (group VI) or their combination (group VII). Motor activities was examined using open-field and catalepsy. Striatal monamines, acetylcholinesterase, excitatory/inhibitory neurotransmitters, redox status, pro-oxidant content, brain inflammatory, apoptotic and antioxidant biomarkers levels were assessed. Besides, histopathological investigations of different brain regions were determined. Groups (IV -GVII) showed improved motor functions of PD rats. Applied drugs significantly increased the brain levels of monoamines with the strongest effect to PUN. Meanwhile, they significantly decreased levels of acetylcholinesterase with a strongest effect to PUN. Moreover, they exhibited significant neuronal protection and anti-inflammatory abilities through significant reduction of the brain levels of COX2, TNF-α and Il-1β with a strongest effect to the PUN. Interestingly; groups (IV - GVII) showed restored glutamate/GABA balance and exhibited a pronounced decrease in caspase-3 content and GSK-3β protein expression levels. In addition, they significantly increased Bcl2 mRNA expression levels with a strongest effect for PUN. All these findings were further confirmed by the histopathological examinations. As a conclusion, we propose VIN and PUN to mitigate the progression of PD via their antioxidant, anti-inflammatory, anti-apoptotic, neurotrophic and neurogenic activities.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
التعليقات: Erratum in: Biomed Pharmacother. 2023 Jun 26;:115060. (PMID: 37380522)
فهرسة مساهمة: Keywords: Niacin; Oxidative stress; Parkinson’s disease; Punicalagin; Vinpocetine; Vitamin E
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Hydrolyzable Tannins)
0 (Neuroprotective Agents)
0 (Vinca Alkaloids)
1406-18-4 (Vitamin E)
2679MF687A (Niacin)
42Z2K6ZL8P (Manganese)
543512OBTC (vinpocetine)
65995-63-3 (punicalagin)
EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
EC 3.1.1.7 (Acetylcholinesterase)
تواريخ الأحداث: Date Created: 20220703 Date Completed: 20220908 Latest Revision: 20230628
رمز التحديث: 20230629
DOI: 10.1016/j.biopha.2022.113330
PMID: 35780621
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2022.113330