دورية أكاديمية
Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception.
| العنوان: | Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception. |
|---|---|
| المؤلفون: | Moldenhauer LM; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Jin M; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia.; Center for Reproductive Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Wilson JJ; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Green ES; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Sharkey DJ; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Salkeld MD; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Bristow TC; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia., Hull ML; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia., Dekker GA; Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia.; Division of Women's Health, Lyell McEwin Hospital, Elizabeth Vale, Australia., Robertson SA; Robinson Research Institute and School of Biomedicine, University of Adelaide, Adelaide, Australia. |
| المصدر: | Endocrinology [Endocrinology] 2022 Sep 01; Vol. 163 (9). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Forkhead Transcription Factors*/metabolism , T-Lymphocytes, Regulatory*/metabolism, Contraception ; Female ; Hormones/metabolism ; Humans ; Phenotype |
| مستخلص: | Regulatory T (Treg) cells are a specialized CD4+ T cell subpopulation that are essential for immune homeostasis, immune tolerance, and protection against autoimmunity. There is evidence that sex-steroid hormones estrogen and progesterone modulate Treg cell abundance and phenotype in women. Since natural oscillations in these hormones are modified by hormonal contraceptives, we examined whether oral contraception (OC) use impacts Treg cells and related T cell populations. T cells were analyzed by multiparameter flow cytometry in peripheral blood collected across the menstrual cycle from healthy women either using OC or without hormonal contraception and from age-matched men. Compared to naturally cycling women, women using OC had fewer Treg cells and an altered Treg cell phenotype. Notably, Treg cells exhibiting a strongly suppressive phenotype, defined by high FOXP3, CD25, Helios, HLADR, CTLA4, and Ki67, comprised a lower proportion of total Treg cells, particularly in the early- and mid-cycle phases. The changes were moderate compared to more substantial differences in Treg cells between women and men, wherein women had fewer Treg cells-especially of the effector memory Treg cell subset-associated with more T helper type 1 (Th1) cells and CD8+ T cells and lower Treg:Th1 cell and Treg:CD8+ T cell ratios than men. These findings imply that OC can modulate the number and phenotype of peripheral blood Treg cells and raise the possibility that Treg cells contribute to the physiological changes and altered disease susceptibility linked with OC use. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.) |
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| فهرسة مساهمة: | Keywords: T cells; autoimmunity; regulatory T cells; sex hormones; tolerance |
| المشرفين على المادة: | 0 (Forkhead Transcription Factors) 0 (Hormones) |
| تواريخ الأحداث: | Date Created: 20220705 Date Completed: 20220809 Latest Revision: 20220907 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9354970 |
| DOI: | 10.1210/endocr/bqac098 |
| PMID: | 35786711 |
| قاعدة البيانات: | MEDLINE |
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