دورية أكاديمية
أعرض في EDS

Diminished Pneumococcal-Specific CD4 + T-Cell Response is Associated With Increased Regulatory T Cells at Older Age.

التفاصيل البيبلوغرافية
العنوان: Diminished Pneumococcal-Specific CD4 + T-Cell Response is Associated With Increased Regulatory T Cells at Older Age.
المؤلفون: He SWJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., van de Garde MDB; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Poelen MCM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., Voß F; Department of Molecular Genetics and Infection Biology, Interfaculty Institute of Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany., Abdullah MR; Department of Molecular Genetics and Infection Biology, Interfaculty Institute of Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany., Hammerschmidt S; Department of Molecular Genetics and Infection Biology, Interfaculty Institute of Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany., van Els CACM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
المصدر: Frontiers in aging [Front Aging] 2021 Nov 03; Vol. 2, pp. 746295. Date of Electronic Publication: 2021 Nov 03 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 9918231199706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-6217 (Electronic) Linking ISSN: 26736217 NLM ISO Abbreviation: Front Aging Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, [2020]-
مستخلص: Respiratory infection caused by Streptococcus pneumoniae is a leading cause of morbidity and mortality in older adults. Acquired CD4 + T cell mechanism are essential for the protection against colonization and subsequent development of infections by S. pneumoniae . In this study, we hypothesized that age-related changes within the CD4 + T-cell population compromise CD4 + T-cell specific responses to S. pneumoniae , thereby contributing to increased susceptibility at older age. To this end, we interrogated the CD4 + T-cell response against the immunogenic pneumococcal protein AliB, part of the unique oligopeptide ABC transporter system responsible for the uptake of nutrients for the bacterium and crucial for the development of pneumococcal meningitis, in healthy young and older adults. Specifically, proliferation of CD4 + T cells as well as concomitant cytokine profiles and phenotypic markers implied in immunosenescence were studied. Older adults showed decreased AliB-induced CD4 + T-cell proliferation that is associated with an increased frequency of regulatory T cells and lower levels of active CD25 + CD127 + CTLA-4 - TIGIT - CD4 + T cells. Additionally, levels of pro-inflammatory cytokines IFNy and IL-17F were decreased at older age. Our findings indicate that key features of a pneumococcal-specific CD4 + T-cell immune response are altered at older age, which may contribute to enhanced susceptibility for pneumococcal infections.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a shared consortium with one of the authors (C.V.E) at time of review.
(Copyright © 2021 He, van de Garde, Pieren, Poelen, Voß, Abdullah, Hammerschmidt and van Els.)
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فهرسة مساهمة: Keywords: CD4+ T cells; Streptococcus pneumoniae; aging; immunosenescence; infection; pneumococcal proteins; proinflammatory cytokines; tregs
تواريخ الأحداث: Date Created: 20220713 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9261371
DOI: 10.3389/fragi.2021.746295
PMID: 35822055
قاعدة البيانات: MEDLINE
الوصف
تدمد:2673-6217
DOI:10.3389/fragi.2021.746295