دورية أكاديمية
أعرض في EDS

Efficacy and durability of bovine virus diarrhea (BVD) virus killed vaccine adjuvanted with monolaurin.

التفاصيل البيبلوغرافية
العنوان: Efficacy and durability of bovine virus diarrhea (BVD) virus killed vaccine adjuvanted with monolaurin.
المؤلفون: Abd El Fadeel MR; Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo, Egypt., Soliman EM; Central Laboratory for Evaluation of Veterinary Biologics, Agriculture Research Center (CLEVB/ARC), Abbasia, Cairo, Egypt., Allam AM; Department of Parasitology and Animal Diseases, Veterinary Research Institute, National Research Centre, Dokki, Giza, Egypt., ElKersh MF; Animal Health Institute AHRI, Agriculture Research Center ARC, Cairo, Egypt., Abd El-Baky RM; Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt., Mustafa A; Faculty of Engineering, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
المصدر: PloS one [PLoS One] 2022 Jul 14; Vol. 17 (7), pp. e0269031. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Bovine Virus Diarrhea-Mucosal Disease* , Diarrhea Virus 1, Bovine Viral* , Diarrhea Viruses, Bovine Viral* , Viral Vaccines*, Adjuvants, Immunologic ; Aluminum Hydroxide ; Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; Cattle ; Diarrhea ; Laurates ; Monoglycerides ; Vaccines, Inactivated
مستخلص: The bovine virus diarrhea virus (BVDV) causes reproductive, enteric, and respiratory diseases. Vaccination is essential in increasing herd resistance to BVDV spread. The selection of an adjuvant is an important factor in the success of the vaccination process. Monolaurin or glycerol monolaurate is a safe compound with an immunomodulatory effect. This study aimed to evaluate the efficacy of monolaurin as a novel adjuvant. This was examined through the preparation of an inactivated BVDV (NADL strain) vaccine adjuvanted with different concentrations of monolaurin and compared with the registered available locally prepared polyvalent vaccine (Pneumo-4) containing BVD (NADL strain), BoHV-1 (Abou Hammad strain), BPI3 (strain 45), and BRSV (strain 375L), and adjuvanted with aluminum hydroxide gel. The inactivated BVDV vaccine was prepared using three concentrations, 0.5%, 1%, and 2%, from monolaurin as adjuvants. A potency test was performed on five groups of animals. The first group, which did not receive vaccination, served as a control group while three other groups were vaccinated using the prepared vaccines. The fifth group received the Pneumo-4 vaccine. Vaccination response was monitored by measuring viral neutralizing antibodies using enzyme-linked immunosorbent assay (ELISA). It was found that the BVD inactivated vaccine with 1% and 2% monolaurin elicited higher neutralizing antibodies that have longer-lasting effects (nine months) with no reaction at the injection site in comparison to the commercial vaccine adjuvanted by aluminum hydroxide gel.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Adjuvants, Immunologic)
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (Laurates)
0 (Monoglycerides)
0 (Vaccines, Inactivated)
0 (Viral Vaccines)
27215-38-9 (monolaurin)
5QB0T2IUN0 (Aluminum Hydroxide)
تواريخ الأحداث: Date Created: 20220714 Date Completed: 20220718 Latest Revision: 20220722
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9282602
DOI: 10.1371/journal.pone.0269031
PMID: 35834444
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0269031