دورية أكاديمية
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Evaluation of glycemic status among hypercholesterolemic patients on atorvastatin in a tertiary care hospital - A retrospective study.

التفاصيل البيبلوغرافية
العنوان: Evaluation of glycemic status among hypercholesterolemic patients on atorvastatin in a tertiary care hospital - A retrospective study.
المؤلفون: Nalini R; Department of Pharmacology, Government Tirunelveli Medical College, Tirunelveli¸ Tamil Nadu, India., Ramya JE; Department of Pharmacology, Government Tirunelveli Medical College, Tirunelveli¸ Tamil Nadu, India., Karthick R; Department of Pharmacology, Government Tirunelveli Medical College, Tirunelveli¸ Tamil Nadu, India.
المصدر: Indian journal of pharmacology [Indian J Pharmacol] 2022 May-Jun; Vol. 54 (3), pp. 165-170.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 7902477 Publication Model: Print Cited Medium: Internet ISSN: 1998-3751 (Electronic) Linking ISSN: 02537613 NLM ISO Abbreviation: Indian J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Pondicherry, Published for the Indian Pharmacological Society by the Dept. of Pharmacology, Jawaharial Institute of Postgraduate Medical Education and Research, [1969?]-
مواضيع طبية MeSH: Diabetes Mellitus*/chemically induced , Diabetes Mellitus, Type 2*/drug therapy , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects , Prediabetic State*/chemically induced, Atorvastatin/adverse effects ; Blood Glucose ; Glycated Hemoglobin ; Humans ; Retrospective Studies ; Tertiary Care Centers
مستخلص: Introduction: Statins are effective in reducing low-density lipoprotein cholesterol and are favorable in primary and secondary prevention of cardiovascular disease. Recent large trials have linked the use of statins and increased incidence of new-onset diabetes mellitus, the possibility of worsening of glucose level in individuals with diabetes following statin therapy, and this possibility is increased with the use of atorvastatin. This study was undertaken to analyze the possibility of the diabetogenic potential of atorvastatin among hypercholesterolemic patients.
Materials and Methods: This retrospective cohort study was conducted in the cardiology department from July 2019 to December 2019. Patients on atorvastatin for more than 6 months with normoglycemia on commencement of therapy were included. The occurrence of prediabetes or new-onset diabetes mellitus after atorvastatin therapy is the outcome of the study. Adverse drug effects to atorvastatin were also recorded and WHO-UMC causality assessment was performed. Descriptive statistics were performed for baseline and demographic characteristics.
Results: Sixty study participants were included in the study. Eighteen (30%) study participants developed prediabetes with an HbA1c value of 5.97 ± 0.22 and 17 (28%) of participants developed new-onset diabetes mellitus with an HbA1c value of 7.24 ± 0.50. Atorvastatin at dose of 40 mg was found to be the most frequently prescribed dose.
Conclusion: Atorvastatin has a dose-dependent risk of developing new-onset diabetes mellitus. Hence, the following statin therapy glycemic status should be periodically monitored especially in patients with a large dose of atorvastatin and also in patients with higher risk factors for diabetes.
Competing Interests: None
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فهرسة مساهمة: Keywords: Atorvastatin; glycemic status; new-onset diabetes mellitus; prediabetes; statins
المشرفين على المادة: 0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
A0JWA85V8F (Atorvastatin)
تواريخ الأحداث: Date Created: 20220718 Date Completed: 20220719 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9396686
DOI: 10.4103/ijp.ijp_943_20
PMID: 35848686
قاعدة البيانات: MEDLINE
الوصف
تدمد:1998-3751
DOI:10.4103/ijp.ijp_943_20