دورية أكاديمية
Development of a nanotechnological hydrogel containing desonide nanocapsules in association with acai oil: design and in vivo evaluation.
| العنوان: | Development of a nanotechnological hydrogel containing desonide nanocapsules in association with acai oil: design and in vivo evaluation. |
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| المؤلفون: | Rosa P; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil., Friedrich ML; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Dos Santos J; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil., Pegoraro NS; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil., Camponogara C; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil., Oliveira SM; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, Brazil., da Silva CB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil.; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Adams AIH; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, Brazil.; Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil. |
| المصدر: | Pharmaceutical development and technology [Pharm Dev Technol] 2022 Jul; Vol. 27 (6), pp. 654-664. Date of Electronic Publication: 2022 Jul 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9610932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9867 (Electronic) Linking ISSN: 10837450 NLM ISO Abbreviation: Pharm Dev Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Monticello, NY : Marcel Dekker, c1996- |
| مواضيع طبية MeSH: | Nanocapsules*, Animals ; Anti-Inflammatory Agents/therapeutic use ; Desonide/pharmacology ; Glucocorticoids ; Hydrogels |
| مستخلص: | Nanotechnological products have been used as strategies to optimize the therapy and minimize the side effects of topical corticoids. The objective of this study was to develop hydrogels by the addition of sclerotium gum to the suspensions of desonide-loaded açai oil-based nanocapsules and to study their biological effect using an animal model of acute skin inflammation. The hydrogels presented a pH compatible with topical application (4.4 to 5.0), nanometric mean diameter (131 to 165 nm), pseudoplastic behavior, and stability under room conditions during 30 days. The in vitro skin permeation/penetration study demonstrated that a higher amount of desonide ( p < 0.05) was retained in the epidermis from the nanotechnological-hydrogels (0.33 to 0.36 µg.cm 2 ) in comparison to the commercial gel cream (0.16 µg.cm 2 ). In the dermis, the nanostructured hydrogels promoted a lower DES retention compared to the non-nanostructured formulations ( p < 0.05). This result may indicate a smaller amount of drug reaching the bloodstream and, thus, fewer side effects can be expected. Concerning the anti-inflammatory effect, the developed hydrogels reduced both ear edema and inflammatory cell infiltration, showing an effect comparable to the commercially available formulation, which presents twice the drug concentration. The hydrogels developed may be considered a promising approach to treat dermatological disorders. |
| فهرسة مساهمة: | Keywords: Açai oil; corticosteroids; ear edema; in vitro permeation; sclerotium gum; semisolid formulation |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Glucocorticoids) 0 (Hydrogels) 0 (Nanocapsules) J280872D1O (Desonide) |
| تواريخ الأحداث: | Date Created: 20220719 Date Completed: 20221011 Latest Revision: 20221011 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/10837450.2022.2103147 |
| PMID: | 35850635 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1097-9867 |
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| DOI: | 10.1080/10837450.2022.2103147 |