دورية أكاديمية

Predictors of mortality among inpatients with COVID-19 infection in a tertiary referral center in the Philippines.

التفاصيل البيبلوغرافية
العنوان: Predictors of mortality among inpatients with COVID-19 infection in a tertiary referral center in the Philippines.
المؤلفون: Malundo AFG; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Taft Avenue, Ermita, Manila, National Capital Region, Philippines., Abad CLR; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Salamat MSS; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Sandejas JCM; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Poblete JB; Department of Medicine, University of the Philippines - Philippine General Hospital, Manila, Philippines., Planta JEG; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Morales SJL; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Gabunada RRW; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Evasan ALM; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines., Cañal JPA; Department of Radiology, University of the Philippines - Philippine General Hospital, Manila, Philippines., Santos JA; Department of Radiology, University of the Philippines - Philippine General Hospital, Manila, Philippines., Manto JT; Department of Radiology, University of the Philippines - Philippine General Hospital, Manila, Philippines., Mercado MEP; Department of Clinical Epidemiology, Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines., Rojo RD; College of Medicine, University of the Philippines, Manila, Philippines., Ornos EDB; College of Medicine, University of the Philippines, Manila, Philippines., Alejandria MM; Division of Infectious Diseases, University of the Philippines - Philippine General Hospital, Manila, Philippines.
المصدر: IJID regions [IJID Reg] 2022 Sep; Vol. 4, pp. 134-142. Date of Electronic Publication: 2022 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918418183106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-7076 (Electronic) Linking ISSN: 27727076 NLM ISO Abbreviation: IJID Reg Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier Ltd., [2021]-
مستخلص: Objectives: The aim of this study was to determine the predictors of mortality and describe laboratory trends among adults with confirmed COVID-19.
Methods: The medical records of adult patients admitted to a referral hospital with COVID-19 were retrospectively reviewed. Demographic and clinical characteristics, and laboratory parameters, were compared between survivors and non-survivors. Predictors of mortality were determined by multivariate analysis. Mean laboratory values were plotted across illness duration.
Results: Of 1215 patients, 203 (16.7%) had mild, 488 (40.2%) moderate, 183 (15.1%) severe, and 341 (28.1%) critical COVID-19 on admission. In-hospital mortality was 18.2% (0% mild, 6.1% moderate, 15.8% severe, 47.5% critical). Predictors of mortality were age ≥ 60 years, COPD, qSOFA score ≥ 2, WBC > 10 × 10 9 /L, absolute lymphocyte count < 1000, neutrophil ≥ 70%, PaO 2 /FiO 2 ratio ≤ 200, eGFR < 90 mL/min/1.73 m 2 , LDH > 600 U/L, and CRP > 12 mg/L. Non-survivors exhibited an increase in LDH and decreases in PaO 2 /FiO 2 ratio and eGFR during the 2nd-3rd week of illness.
Conclusion: The overall mortality rate was high. Predictors of mortality were similar to those of other reports globally. Marked inflammation and worsening pulmonary and renal function were evident among non-survivors by the 2nd-3rd week of illness.
Competing Interests: The authors declare no conflicts of interest.
(© 2022 The Author(s).)
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فهرسة مساهمة: Keywords: COVID-19; Philippines; epidemiology; mortality
تواريخ الأحداث: Date Created: 20220720 Latest Revision: 20220731
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9281405
DOI: 10.1016/j.ijregi.2022.07.009
PMID: 35854825
قاعدة البيانات: MEDLINE