دورية أكاديمية
Multimodal perception links cellular state to decision-making in single cells.
| العنوان: | Multimodal perception links cellular state to decision-making in single cells. |
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| المؤلفون: | Kramer BA; Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.; Molecular Life Sciences PhD program, Life Science Zurich Graduate School, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Sarabia Del Castillo J; Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Pelkmans L; Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. |
| المصدر: | Science (New York, N.Y.) [Science] 2022 Aug 05; Vol. 377 (6606), pp. 642-648. Date of Electronic Publication: 2022 Jul 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Signal Transduction* , Single-Cell Analysis*, Epidermal Growth Factor/pharmacology ; Epithelial Cells/drug effects ; Epithelial Cells/physiology ; Humans |
| مستخلص: | Individual cells make decisions that are adapted to their internal state and surroundings, but how cells can reliably do this remains unclear. To study the information processing capacity of human cells, we conducted multiplexed quantification of signaling responses and markers of the cellular state. Signaling nodes in a network displayed adaptive information processing, which led to heterogeneous growth factor responses and enabled nodes to capture partially nonredundant information about the cellular state. Collectively, as a multimodal percept this gives individual cells a large information processing capacity to accurately place growth factor concentration within the context of their cellular state and make cellular state-dependent decisions. Heterogeneity and complexity in signaling networks may have coevolved to enable specific and context-aware cellular decision-making in a multicellular setting. |
| المشرفين على المادة: | 62229-50-9 (Epidermal Growth Factor) |
| تواريخ الأحداث: | Date Created: 20220720 Date Completed: 20220808 Latest Revision: 20220823 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1126/science.abf4062 |
| PMID: | 35857483 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.abf4062 |